Change search
ReferencesLink to record
Permanent link

Direct link
Infants' Peripheral Blood Lymphocyte Composition Reflects Both Maternal and Post-Natal Infection with Plasmodium falciparum
Show others and affiliations
Number of Authors: 16
2015 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 11, e0139606Article in journal (Refereed) Published
Abstract [en]

Maternal parasitoses modulate fetal immune development, manifesting as altered cellular immunological activity in cord blood that may be linked to enhanced susceptibility to infections in early life. Plasmodium falciparum typifies such infections, with distinct placental infection-related changes in cord blood exemplified by expanded populations of parasite antigen-specific regulatory T cells. Here we addressed whether such early-onset cellular immunological alterations persist through infancy. Specifically, in order to assess the potential impacts of P. falciparum infections either during pregnancy or during infancy, we quantified lymphocyte subsets in cord blood and in infants' peripheral blood during the first year of life. The principal age-related changes observed, independent of infection status, concerned decreases in the frequencies of CD4(+), NKdim and NKT cells, whilst CD8(+), Treg and Teff cells' frequencies increased from birth to 12 months of age. P. falciparum infections present at delivery, but not those earlier in gestation, were associated with increased frequencies of Treg and CD8(+) T cells but fewer CD4(+) and NKT cells during infancy, thus accentuating the observed age-related patterns. Overall, P. falciparum infections arising during infancy were associated with a reversal of the trends associated with maternal infection i.e. with more CD4(+) cells, with fewer Treg and CD8(+) cells. We conclude that maternal P. falciparum infection at delivery has significant and, in some cases, year-long effects on the composition of infants' peripheral blood lymphocyte populations. Those effects are superimposed on separate and independent age-as well as infant infection-related alterations that, respectively, either match or run counter to them.

Place, publisher, year, edition, pages
2015. Vol. 10, no 11, e0139606
National Category
Other Natural Sciences
URN: urn:nbn:se:su:diva-124754DOI: 10.1371/journal.pone.0139606ISI: 000365154600001PubMedID: 26580401OAI: diva2:892176
Available from: 2016-01-08 Created: 2016-01-04 Last updated: 2016-01-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Troye-Blomberg, Marita
By organisation
Department of Molecular Biosciences, The Wenner-Gren Institute
In the same journal
Other Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 16 hits
ReferencesLink to record
Permanent link

Direct link