Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene
2016 (English)In: Biochemistry and Biophysics Reports, ISSN 2405-5808, Vol. 5, 141-145 p.Article in journal (Refereed) Published
The nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) and the related 2,4-dinitrotoluene (DNT) aretoxic environmental pollutants. The biotransformation and detoxication of these persistent compoundsin higher organisms are of great significance from a health perspective as well as for the biotechnological challenge of bioremediation of contaminated soil. We demonstrate that different human glutathionetransferases (GSTs) and GSTs from the fruit fly Drosophila melanogaster are catalysts of the biotransformationof TNT and DNT. The human GSTs had significant but modest catalytic activities with both DNT and TNT. However, D. melanogaster GSTE6 and GSTE7 displayed outstanding high activities withboth substrates.
Place, publisher, year, edition, pages
2016. Vol. 5, 141-145 p.
Glutathione conjugation, 2, 4, 6-trinitrotoluene detoxication, 2, 4-dinitrotoluene detoxication, Drosophila GSTs, Human GSTs
Biochemistry and Molecular Biology Chemical Sciences
Research subject Neurochemistry with Molecular Neurobiology
IdentifiersURN: urn:nbn:se:su:diva-126346DOI: 10.1016/j.bbrep.2015.12.003OAI: oai:DiVA.org:su-126346DiVA: diva2:899224
FunderSwedish Research Council, 2012-5161