Intergenomic interactions between mitochondrial and Y-linked genes shape male mating patterns and fertility in Drosophila melanogaster
Number of Authors: 4
2015 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 69, no 11, 2876-2890 p.Article in journal (Refereed) Published
Under maternal inheritance, mitochondrial genomes are prone to accumulate mutations that exhibit male-biased effects. Such mutations should, however, place selection on the nuclear genome for modifier adaptations that mitigate mitochondrial-incurred male harm. One gene region that might harbor such modifiers is the Y-chromosome, given the abundance of Y-linked variation for male fertility, and because Y-linked modifiers would not exert antagonistic effects in females because they would be found only in males. Recent studies in Drosophila revealed a set of nuclear genes whose expression is sensitive to allelic variation among mtDNA-and Y-haplotypes, suggesting these genes might be entwined in evolutionary conflict between mtDNA and Y. Here, we test whether genetic variation across mtDNA and Y haplotypes, sourced from three disjunct populations, interacts to affect male mating patterns and fertility across 10 days of early life in D. melanogaster. We also investigate whether coevolved mito-Y combinations outperform their evolutionarily novel counterparts, as predicted if the interacting Y-linked variance is comprised of modifier adaptations. Although we found no evidence that coevolved mito-Y combinations outperformed their novel counterparts, interactions between mtDNA and Y-chromosomes affected male mating patterns. These interactions were dependent on male age; thus male reproductive success was shaped by G x G x E interactions.
Place, publisher, year, edition, pages
2015. Vol. 69, no 11, 2876-2890 p.
Adaptation, genomic conflict, mitonuclear, mtDNA, male fertility, sexual conflict
IdentifiersURN: urn:nbn:se:su:diva-126852DOI: 10.1111/evo.12788ISI: 000368248800007PubMedID: 26419212OAI: oai:DiVA.org:su-126852DiVA: diva2:906335