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Olfactory memory in the old and very old: relations to episodic and semantic memory and APOE genotype
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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Number of Authors: 6
2016 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 38, 118-126 p.Article in journal (Refereed) Published
Abstract [en]

The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to investigate whether olfactory memory in old age is best conceptualized as a distinct category, differentiated from episodic and semantic memory. Further, potential olfactory dedifferentiation and genetic associations (APOE) to olfactory function in late senescence were investigated. Results are in support of a 3-factor solution where olfactory memory, as indexed by episodic odor recognition and odor identification, is modeled separately from episodic and semantic memory for visual and verbal information. Increasing age was associated with poorer olfactory memory performance, and observed age-related deficits were further exacerbated for carriers of the APOE epsilon 4 allele; these effects tended to be larger for olfactory memory compared to episodic and semantic memory pertaining to other sensory systems (vision, auditory). Finally, stronger correlations between olfactory and episodic memory, indicating dedifferentiation, were observed in the older age groups.

Place, publisher, year, edition, pages
2016. Vol. 38, 118-126 p.
Keyword [en]
Aging, APOE, Dedifferentiation, Memory, Olfaction
National Category
Geriatrics Gerontology, specializing in Medical and Health Sciences Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-127366DOI: 10.1016/j.neurobiolaging.2015.11.012ISI: 000368991300014PubMedID: 26827650OAI: oai:DiVA.org:su-127366DiVA: diva2:910888
Available from: 2016-03-10 Created: 2016-03-02 Last updated: 2016-06-22Bibliographically approved

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Larsson, Maria
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Perception and psychophysicsAging Research Center (ARC), (together with KI)
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Neurobiology of Aging
GeriatricsGerontology, specializing in Medical and Health SciencesNeurosciences

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