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RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian Brain
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 2
2016 (English)In: Trends in Genetics, ISSN 0168-9525, E-ISSN 1362-4555, Vol. 32, no 3, 165-175 p.Article, review/survey (Refereed) Published
Abstract [en]

Post-transcriptional RNA modification by adenosine to inosine (A-to-I) editing expands the functional output of many important neuronally expressed genes. The mechanism provides flexibility in the proteome by expanding the variety of isoforms, and is a requisite for neuronal function. Indeed, targets for editing include key mediators of synaptic transmission with an overall significant effect on neuronal signaling. In addition, editing influences splice-site choice and miRNA targeting capacity, and thereby regulates neuronal gene expression. Editing efficiency at most of these sites increases during neuronal differentiation and brain maturation in a spatiotemporal manner. This editing-induced dynamics in the transcriptome is essential for normal brain development, and we are only beginning to understand its role in neuronal function. In this review we discuss the impact of RNA editing in the brain, with special emphasis on the physiological consequences for neuronal development and plasticity.

Place, publisher, year, edition, pages
2016. Vol. 32, no 3, 165-175 p.
National Category
Biological Sciences
Research subject
Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-129079DOI: 10.1016/j.tig.2015.12.005ISI: 000371843000004PubMedID: 26803450OAI: oai:DiVA.org:su-129079DiVA: diva2:922833
Available from: 2016-04-25 Created: 2016-04-14 Last updated: 2017-05-08Bibliographically approved

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