Change search
ReferencesLink to record
Permanent link

Direct link
CD161(int)CD8+T cells: a novel population of highly functional, memory CD8+T cells enriched within the gut
Show others and affiliations
Number of Authors: 18
2016 (English)In: Mucosal Immunology, ISSN 1933-0219, E-ISSN 1935-3456, Vol. 9, no 2, 401-413 p.Article in journal (Refereed) Published
Abstract [en]

The C-type lectin-like receptor CD161 is expressed by lymphocytes found in human gut and liver, as well as blood, especially natural killer (NK) cells, T helper 17 (Th17) cells, and a population of unconventional Tcells known as mucosalassociated invariant T (MAIT) cells. The association of high CD161 expression with innate T-cell populations including MAITcells is established. Here we show that CD161 is also expressed, at intermediate levels, on a prominent subset of polyclonal CD8+ T cells, including antiviral populations that display a memory phenotype. These memory CD161(int)CD8+ Tcells are enriched within the colon and express both CD103 and CD69, markers associated with tissue residence. Furthermore, this population was characterized by enhanced polyfunctionality, increased levels of cytotoxic mediators, and high expression of the transcription factors T-bet and eomesodermin (EOMES). Such populations were induced by novel vaccine strategies based on adenoviral vectors, currently in trial against hepatitis C virus. Thus, intermediate CD161 expression marks potent polyclonal, polyfunctional tissue-homing CD8+ T-cell populations in humans. As induction of such responses represents a major aim of T-cell prophylactic and therapeutic vaccines in viral disease and cancer, analysis of these populations could be of value in the future.

Place, publisher, year, edition, pages
2016. Vol. 9, no 2, 401-413 p.
National Category
Biological Sciences Immunology in the medical area
Identifiers
URN: urn:nbn:se:su:diva-129634DOI: 10.1038/mi.2015.69ISI: 000372425800010PubMedID: 26220166OAI: oai:DiVA.org:su-129634DiVA: diva2:925014
Available from: 2016-04-29 Created: 2016-04-26 Last updated: 2016-04-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sverremark-Ekström, Eva
By organisation
Department of Molecular Biosciences, The Wenner-Gren Institute
In the same journal
Mucosal Immunology
Biological SciencesImmunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 6 hits
ReferencesLink to record
Permanent link

Direct link