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Multipotent versus differentiated cell fate selection in the developing Drosophila airways
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. Stockholm University, Science for Life Laboratory (SciLifeLab). Justus Liebig University of Giessen, Germany.
Number of Authors: 4
2015 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 4, e09646Article in journal (Refereed) Published
Abstract [en]

Developmental potentials of cells are tightly controlled at multiple levels. The embryonic Drosophila airway tree is roughly subdivided into two types of cells with distinct developmental potentials: a proximally located group of multipotent adult precursor cells (P-fate) and a distally located population of more differentiated cells (D-fate). We show that the GATA-family transcription factor (TF) Grain promotes the P-fate and the POU-homeobox TF Ventral veinless (Vvl/Drifter/U-turned) stimulates the D-fate. Hedgehog and receptor tyrosine kinase (RTK) signaling cooperate with Vvl to drive the D-fate at the expense of the P-fate while negative regulators of either of these signaling pathways ensure P-fate specification. Local concentrations of Decapentaplegic/BMP, Wingless/Wnt, and Hedgehog signals differentially regulate the expression of D-factors and P-factors to transform an equipotent primordial field into a concentric pattern of radially different morphogenetic potentials, which gradually gives rise to the distal-proximal organization of distinct cell types in the mature airway.

Place, publisher, year, edition, pages
2015. Vol. 4, e09646
National Category
Biological Sciences
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URN: urn:nbn:se:su:diva-130019DOI: 10.7554/eLife.09646ISI: 000373813200001OAI: oai:DiVA.org:su-130019DiVA: diva2:927051
Available from: 2016-05-10 Created: 2016-05-09 Last updated: 2016-07-05Bibliographically approved

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Matsuda, RyoHosono, ChieSamakovlis, Christos
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Department of Molecular Biosciences, The Wenner-Gren InstituteScience for Life Laboratory (SciLifeLab)
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