Enzyme- and Ruthenium-Catalyzed Enantioselective Transformation of alpha-Allenic Alcohols into 2,3-Dihydrofurans
Number of Authors: 4
2016 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 55, no 18, 5568-5572 p.Article in journal (Refereed) Published
An efficient one-pot method for the enzyme- and ruthenium-catalyzed enantioselective transformation of alpha-allenic alcohols into 2,3-dihydrofurans has been developed. The method involves an enzymatic kinetic resolution and a subsequent ruthenium-catalyzed cycloisomerization, which provides 2,3-dihydrofurans with excellent enantioselectivity (up to >99%ee). A ruthenium carbene species was proposed as a key intermediate in the cycloisomerization.
Place, publisher, year, edition, pages
2016. Vol. 55, no 18, 5568-5572 p.
allenic alcohols, asymmetric catalysis, cycloisomerization, kinetic resolution, ruthenium
IdentifiersURN: urn:nbn:se:su:diva-130865DOI: 10.1002/anie.201601505ISI: 000375113300030PubMedID: 27061624OAI: oai:DiVA.org:su-130865DiVA: diva2:934189