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Selection for brain size impairs innate, but not adaptive immune responses
Stockholm University, Faculty of Science, Department of Zoology. University of Veterinary Medicine, Austria.
Stockholm University, Faculty of Science, Department of Zoology.
Number of Authors: 3
2016 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 283, no 1826, 20152857Article in journal (Refereed) Published
Abstract [en]

Both the brain and the imnume system are energetically demanding organs, and when natural selection favours increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies (Poecilia reticulata) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over 8 days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared with large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.

Place, publisher, year, edition, pages
2016. Vol. 283, no 1826, 20152857
Keyword [en]
brain size, immune response, trade-off
National Category
Biological Sciences
URN: urn:nbn:se:su:diva-130969DOI: 10.1098/rspb.2015.2857ISI: 000374921900015OAI: diva2:936544
Available from: 2016-06-14 Created: 2016-06-09 Last updated: 2016-06-14Bibliographically approved

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Kotrschal, AlexanderKolm, Niclas
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