Change search
ReferencesLink to record
Permanent link

Direct link
Selection for brain size impairs innate, but not adaptive immune responses
Stockholm University, Faculty of Science, Department of Zoology. University of Veterinary Medicine, Austria.
Stockholm University, Faculty of Science, Department of Zoology.
Number of Authors: 3
2016 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 283, no 1826, 20152857Article in journal (Refereed) Published
Abstract [en]

Both the brain and the imnume system are energetically demanding organs, and when natural selection favours increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies (Poecilia reticulata) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over 8 days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared with large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.

Place, publisher, year, edition, pages
2016. Vol. 283, no 1826, 20152857
Keyword [en]
brain size, immune response, trade-off
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-130969DOI: 10.1098/rspb.2015.2857ISI: 000374921900015OAI: oai:DiVA.org:su-130969DiVA: diva2:936544
Available from: 2016-06-14 Created: 2016-06-09 Last updated: 2016-06-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Kotrschal, AlexanderKolm, Niclas
By organisation
Department of Zoology
In the same journal
Proceedings of the Royal Society of London. Biological Sciences
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 8 hits
ReferencesLink to record
Permanent link

Direct link