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Monthly variation in faeces: blood concentration ratio of persistent organic pollutants over the first year of life
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
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Number of Authors: 11
2016 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 147, 259-268 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies have found that the concentrations of a range of persistent organic pollutants (POPs) in faeces is linearly proportional to the POP concentrations in blood of human adults irrespective of age and gender. In order to investigate the correlation between POP concentrations in faeces and blood in infants, the monthly variation of POP concentrations in faeces over the first year of life of one infant was investigated in this study and compared to modelled blood concentrations. Faecal samples were collected from one male infant daily. The samples were pooled by month and analysed for three selected POPs (2,2',4,4',5,5'-Hexachlorobiphenyl (PCB153), p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and 2,2',4,4'-tetrabromodiphenyl ether (BDE47)). The POP concentrations in faecal samples increased for the first four months by a factor of 2.9, 4.9 and 1.4 for PCB153, BDE47, and p,p'-DDE, respectively. The faecal concentrations of all POPs decreased rapidly following the introduction of formula and solid food to the diet and subsequent weaning of the infant. Further, a one-compartment model was developed to estimate the daily POP concentrations in the blood of the infant. The POP concentrations in blood were predicted to vary much less over the first year than those observed in faeces. The faeces:blood concentration ratio of selected POPs (K-fb) differed significantly (P < 0.0001) between the period before and after weaning, and observed changes in K-fb are far greater than the uncertainty in the estimated K-fb. A more stable K-fb after weaning indicates the possibility of applying the stable K-fb values for non-invasive assessment of internal exposure in infants after weaning. The intra-individual variation in K-fb in infants is worthy of further investigation.

Place, publisher, year, edition, pages
2016. Vol. 147, 259-268 p.
Keyword [en]
Infant, POPs, Noninvasive bio-monitoring, Faeces:blood concentration ratio, Model
National Category
Earth and Related Environmental Sciences Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:su:diva-131213DOI: 10.1016/j.envres.2016.02.017ISI: 000374275700031PubMedID: 26918839OAI: oai:DiVA.org:su-131213DiVA: diva2:936748
Available from: 2016-06-14 Created: 2016-06-14 Last updated: 2016-06-14Bibliographically approved

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McLachlan, Michael S.
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