Change search
ReferencesLink to record
Permanent link

Direct link
Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats
Show others and affiliations
Number of Authors: 9
2016 (English)In: Journal of Diabetes Research, ISSN 2314-6745, E-ISSN 2314-6753, 9095648Article in journal (Refereed) Published
Abstract [en]

Our previous studies testified the beneficial effect of central galanin on insulin sensitivity of type 2 diabetic rats. The aim of the study was further to investigate whether central M617, a galanin receptor 1 agonist, can benefit insulin sensitivity. The effects of intracerebroventricular administration of M617 on insulin sensitivity and insulin signaling were evaluated in adipose tissues of type 2 diabetic rats. The results showed that central injection of M617 significantly increased plasma adiponectin contents, glucose infusion rates in hyperinsulinemic-euglycemic clamp tests, GLUT4 mRNA expression levels, GLUT4 contents in plasma membranes, and total cell membranes of the adipose cells but reduced the plasma C-reactive protein concentration in nondiabetic and diabetic rats. The ratios of GLUT4 contents were higher in plasma membranes to total cell membranes in both nondiabetic and diabetic M617 groups than each control. In addition, the central administration of M617 enhanced the ratios of pAkt/Akt and pAS160/AS160, but not phosphorylative cAMP response element-binding protein (pCREB)/CREB in the adipose cells of nondiabetic and diabetic rats. These results suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats.

Place, publisher, year, edition, pages
2016. 9095648
National Category
Chemical Sciences Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:su:diva-131174DOI: 10.1155/2016/9095648ISI: 000375316700001OAI: oai:DiVA.org:su-131174DiVA: diva2:939926
Available from: 2016-06-20 Created: 2016-06-14 Last updated: 2016-06-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Langel, Ülo
By organisation
Department of Neurochemistry
In the same journal
Journal of Diabetes Research
Chemical SciencesEndocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 3 hits
ReferencesLink to record
Permanent link

Direct link