Change search
ReferencesLink to record
Permanent link

Direct link
Body Mass Index Predicts Progression of Mild Cognitive Impairment to Dementia
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). ‘Luigi Sacco' Hospital, University of Milan, Italy.
Show others and affiliations
Number of Authors: 10
2016 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 41, no 3-4, 172-180 p.Article in journal (Refereed) Published
Abstract [en]

Aims: To examine the relationship between body mass index (BMI) and progression to dementia and Alzheimer's disease (AD) in mild cognitive impairment (MCI). Materials and Methods: Two hundred and twenty-eight MCI subjects (mean age 74.04 +/- 6.94 years; 57% female) from a memory clinic were followed for 2.40 +/- 1.58 years. Baseline height and weight were used to calculate the BMI. The main outcome was progression to dementia (DSM-IV criteria) and AD (NINCDS-ADRDA criteria). Cox proportional hazard models were used to assess the longitudinal association of BMI with dementia and AD, adjusting for a comprehensive set of covariates, including vascular risk factors/diseases and neuroimaging profiles. Results: Out of 228 subjects with MCI, 117 (51.3%) progressed to dementia. Eighty-nine (76%) of the incident dementia cases had AD. In both unadjusted and multi-adjusted models, a higher BMI was associated with a reduced risk of dementia (multi-adjusted HR 0.9; 95% CI 0.8-0.9) and AD (multi-adjusted HR 0.9; 95% CI 0.8-0.9). Being underweight increased the risk of all types of dementia (multi-adjusted HR 2.5; 95% CI 1.2-5.1) but was not specifically associated with AD (multi-adjusted HR 2.2; 95% CI 0.9-5.3). Conclusions: BMI predicted progression of MCI to dementia and AD. In particular, a higher BMI was associated with a lower risk of dementia and AD, and underweight was associated with a higher risk of dementia. BMI assessment may improve the prognostic accuracy of MCI in clinical practice.

Place, publisher, year, edition, pages
2016. Vol. 41, no 3-4, 172-180 p.
Keyword [en]
Alzheimer's disease, Body mass index, Dementia, Mild cognitive impairment, Weight loss
National Category
Geriatrics Neurosciences
URN: urn:nbn:se:su:diva-131567DOI: 10.1159/000444216ISI: 000376570700005PubMedID: 27028129OAI: diva2:943075
Available from: 2016-06-27 Created: 2016-06-21 Last updated: 2016-06-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Aging Research Center (ARC), (together with KI)
In the same journal
Dementia and Geriatric Cognitive Disorders

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 2 hits
ReferencesLink to record
Permanent link

Direct link