Change search
ReferencesLink to record
Permanent link

Direct link
Towards a paradigm shift in innate immunity-seminal work by Hans G. Boman and co-workers
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 2
2016 (English)In: Philosophical Transactions of the Royal Society of London. Biological Sciences, ISSN 0962-8436, E-ISSN 1471-2970, Vol. 371, no 1695, 20150303Article, book review (Refereed) Published
Abstract [en]

Four decades ago, immunological research was dominated by the field of lymphoid biology. It was commonly accepted that multicellular eukaryotes defend themselves through phagocytosis. The lack of lymphoid cells in insects and other simpler animals, however, led to the common notion that they might simply lack the capacity defend themselves with humoral factors. This view was challenged by microbiologist Hans G. Boman and co-workers in a series of publications that led to the advent of antimicrobial peptides as a universal arm of the immune system. Besides ingenious research, Boman ignited his work by posing the right questions. He started off by asking himself a simple question: 'Antibodies take weeks to produce while many microbes divide hourly; so how come we stay healthy?'. This led to two key findings in the field: the discovery of an inducible and highly potent antimicrobial immune response in Drosophila in 1972, followed by the characterization of cecropin in 1981. Despite broadly being considered an insect-specific response at first, the work of Boman and co-workers eventually created a bandwagon effect that unravelled various aspects of innate immunity. This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.

Place, publisher, year, edition, pages
2016. Vol. 371, no 1695, 20150303
Keyword [en]
peptide antibiotics, antimicrobial peptides, insect immunity, humoral immunity, paradigm shift
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-132065DOI: 10.1098/rstb.2015.0303ISI: 000376160900013OAI: oai:DiVA.org:su-132065DiVA: diva2:948243
Available from: 2016-07-10 Created: 2016-07-06 Last updated: 2016-07-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Faye, Ingrid
By organisation
Department of Molecular Biosciences, The Wenner-Gren Institute
In the same journal
Philosophical Transactions of the Royal Society of London. Biological Sciences
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link