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The interrelationship between attentional and executive deficits in major depressive disorder
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Newcastle University, UK.
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Number of Authors: 6
2016 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 134, no 1, 73-82 p.Article in journal (Refereed) Published
Abstract [en]

ObjectiveCognitive dysfunction is an established feature of major depressive disorder (MDD). However, it remains unclear whether deficits in different cognitive domains are relatively independent or originate from a circumscribed primary deficit'. This study tested the hypothesis that a deficit in attention represents a primary deficit in depression. MethodNeuropsychological function was assessed in 30 depressed patients with MDD and 34 control participants. Cognitive composites were derived from a minimum of three tests and included attention, executive function, visuospatial memory and verbal memory. A multivariate analysis of variance was used to assess group differences in overall cognitive performance, and multiple regression models were used to evaluate the role of attention in deficits in other domains. ResultsThe cognitive deficit in the depressed sample was found to be characterized by poorer performance in attention and executive function. When evaluating the interrelationship between the two deficits, the attentional deficit was found to persist when variability in executive function was statistically accounted for, whilst the executive deficit was eliminated when attention was accounted for. ConclusionThe results demonstrated that the attentional deficit could not be explained by deficits in executive function, which provides support for a primary attention deficit in depression.

Place, publisher, year, edition, pages
2016. Vol. 134, no 1, 73-82 p.
Keyword [en]
affective disorders, depression, cognitive functioning, neurocognition, neuropsychology
National Category
Clinical Medicine
URN: urn:nbn:se:su:diva-132557DOI: 10.1111/acps.12570ISI: 000378706000009PubMedID: 27037665OAI: diva2:953623
Available from: 2016-08-18 Created: 2016-08-15 Last updated: 2016-08-18Bibliographically approved

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