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Weight of evidence evaluation and systematic review in EU chemical risk assessment: Foundation is laid but guidance is needed
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Number of Authors: 2
2016 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 92-93, 590-596 p.Article, review/survey (Refereed) Published
Abstract [en]

The aim of this review was to investigate if and how the application of weight of evidence (WoE) evaluation or systematic review (SR) in chemical risk assessment is promoted within different regulatory frameworks in the European Union. Legislative and relevant guidance documents within nine regulatory frameworks were scrutinized and compared. WoE evaluation or SR is promoted in seven of the investigated frameworks but sufficient guidance for how to perform these processes is generally lacking. None of the investigated frameworks give enough guidance for generating robust and reproducible WoE evaluations or SRs. In conclusion, the foundation for use of WoE evaluation and SR is laid-in the majority of the investigated frameworks, but there is a need to provide more structured and detailed guidance. In order to make the process of developing guidance as efficient as possible, and to ensure smooth transfer of risk assessment's between frameworks if a chemical is risk assessed both as, for example, a biocide and an industrial chemical, it is recommended that guidance is developed jointly by the European regulatory agencies.

Place, publisher, year, edition, pages
2016. Vol. 92-93, 590-596 p.
Keyword [en]
Weight of evidence, Systematic review, Evidence integration, Chemical risk assessment, Chemical legislation
National Category
Environmental Sciences
URN: urn:nbn:se:su:diva-132546DOI: 10.1016/j.envint.2015.10.008ISI: 000378951700065PubMedID: 26682868OAI: diva2:955287
Available from: 2016-08-25 Created: 2016-08-15 Last updated: 2016-08-25Bibliographically approved

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Ågerstrand, MarleneBeronius, Anna
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