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PAH exposure and relationship between buccal micronucleus cytome assay and urinary 1-hydroxypyrene levels among cashew nut roasting workers
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2016 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 258, S223-S224 p.Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

The present study conducted the first assessment of the occupational risk associated to artisanal cashew nut roasting by the use of exposure and effect biomarkers, as well as the characterization and dispersion analysis of the released particulate matter (PM). The PM concentrations in the exposed area were higher than in the non-exposed area. Furthermore, in the control area yielded a higher prevalence of coarse particles, while in the exposed area was observed fine particles. The morphological analysis showed a wide variety of particles. Biomass burning tracers K, Cl, S and Ca were the major inorganic compounds and polycyclic aromatic hydrocarbons (PAHs) with mutagenic and carcinogenic potential, such as benzo[a]pyrene, benzo[b]fluoranthene, benzo[a]anthracene, benzo[j]fluoranthene and indeno[1,2,3-c,d]pyrene were the most abundant PAHs. In addition, atmospheric modeling analysis suggest that these particles can reach regions higher than 40 kilometers. Occupational PAH exposure was confirmed by increases in 1-OHP levels in cashew nut workers. The frequencies of BMCyt biomarkers of genotoxic (micronuclei and nuclear bud) and cytotoxic (pyknosis, karyolysis, karyorrhexis and condensed chromatin) were higher in the exposed group (p < 0.0001) compared with the control group. The influence of factors such as age on the micronucleus was evidenced and a correlation between 1-OHP and MN was observed. It was the first study to found a correlation between these types of biomarkers. The uses of exposure and effect biomarkers were therefore efficient in assessing the occupational risk associated with artisanal cashew nut roasting and the high rates of PM2.5 are considered a potential contributor to this effect.

Place, publisher, year, edition, pages
2016. Vol. 258, S223-S224 p.
National Category
Pharmacology and Toxicology
Research subject
Analytical Chemistry; Atmospheric Sciences and Oceanography; Biochemistry
Identifiers
URN: urn:nbn:se:su:diva-133669DOI: 10.1016/j.toxlet.2016.06.1804OAI: oai:DiVA.org:su-133669DiVA: diva2:968149
Conference
The 52nd Congress of the European Societies of Toxicology (EUROTOX), Fibes Congress Center, Seville, Spain, 4 - 7 September 2016
Available from: 2016-09-12 Created: 2016-09-12 Last updated: 2016-12-23Bibliographically approved

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Sadiktsis, IoannisWesterholm, Roger
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Department of Environmental Science and Analytical Chemistry
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