Thiazole, Imidazole and Oxazoline Based N,P-Ligands for Palladium-Catalyzed Cycloisomerization of 1,6-Enynes
Number of Authors: 6
2016 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 20, 3427-3433 p.Article in journal (Refereed) Published
A series of N,P-ligands were prepared and evaluated in the asymmetric palladium-catalyzed cycloisomerization of allyl propargyl ether substrates. The reactivity and enantioselectivity of the reaction was shown to be highly dependent on the chiral skeleton of the ligand structures with ee's ranging from 22-99 %. The proton source had a significant impact on the enantioselectivity. The generation of palladium hydride from formic acid led to the highest ee. A selectivity model based on a proposed transition state was used to predict and explain the enantiomeric outcome of the reaction.
Place, publisher, year, edition, pages
2016. no 20, 3427-3433 p.
Cyclization, Isomerization, Enynes, N, P ligands, Palladium, Density functional calculations
IdentifiersURN: urn:nbn:se:su:diva-133232DOI: 10.1002/ejoc.201600468ISI: 000380138100023OAI: oai:DiVA.org:su-133232DiVA: diva2:968442