Change search
ReferencesLink to record
Permanent link

Direct link
Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. (Psychoneuroimmunology)
Show others and affiliations
2016 (English)In: Journal of behavioral medicine, ISSN 0160-7715, E-ISSN 1573-3521, Vol. 39, no 5, 916-924 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.

Place, publisher, year, edition, pages
2016. Vol. 39, no 5, 916-924 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:su:diva-133850DOI: 10.1007/s10865-016-9769-zPubMedID: 27469518Local ID: P-3360OAI: diva2:971915
Available from: 2016-09-19 Created: 2016-09-19 Last updated: 2016-09-19

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lekander, Mats
By organisation
Stress Research InstituteStockholm University
In the same journal
Journal of behavioral medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

ReferencesLink to record
Permanent link

Direct link