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Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden; Universitätsklinikum Essen, Germany.
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2016 (English)In: Journal of behavioral medicine, ISSN 0160-7715, E-ISSN 1573-3521, Vol. 39, no 5, 916-924 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.

Place, publisher, year, edition, pages
2016. Vol. 39, no 5, 916-924 p.
Keyword [en]
Chronic pain, Cognitive behavioral therapy (CBT), Psychological inflexibility, Chronic low-grade inflammation, Cytokines, Treatment responders
National Category
Applied Psychology
Identifiers
URN: urn:nbn:se:su:diva-133850DOI: 10.1007/s10865-016-9769-zISI: 000382887100017PubMedID: 27469518Local ID: P-3360OAI: oai:DiVA.org:su-133850DiVA: diva2:971915
Available from: 2016-09-19 Created: 2016-09-19 Last updated: 2016-10-31Bibliographically approved

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Lasselin, JulieAxelsson, JohnAndreasson, AnnaLekander, Mats
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