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Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden; University of Duisburg-Essen, Germany.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
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2016 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 57, 30-37 p.Article in journal (Refereed) Published
Abstract [en]

Lipopolysaccharide (LPS) administration is a well-established model to assess afferent immune-to-brain communication and behavioral aspects of inflammation. Nevertheless, only few studies in comparatively small samples have assessed state anxiety as a psychological component of sickness behavior despite possible clinical implications for the pathophysiology of neuropsychiatric conditions. Thus, the goal of the present analyses carried out in a large, pooled dataset from two independent study sites was to analyze the state anxiety response to LPS administration and to investigate predictors (i.e., cytokine changes; pre-existing anxiety and depression symptoms assessed with the Hospital Anxiety and Depression Scale) of the LPS-induced state anxiety changes at different time points after LPS administration. Data from 186 healthy volunteers who participated in one of six randomized, placebo-controlled human studies involving intravenous administration of LPS at doses of 0.4-0.8ng/kg body weight were combined. State anxiety as well as circulating interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-10 concentrations were significantly increased 2h and 3h after LPS administration, with a peak at 2h, and returned to baseline 6h after administration. Greater changes in IL-6 from baseline to 3h after LPS administration significantly and independently predicted a more pronounced LPS-induced state anxiety response. In addition, higher pre-existing subclinical anxiety symptoms significantly predicted a lower increase in state anxiety 3h and 6h after LPS-administration, which was mediated by TNF-α changes. In conclusion, our findings give additional support for a putative role of inflammatory mechanisms in the pathophysiology of stress-related and anxiety disorders and give new insight on the potential role of pre-existing subclinical affective symptoms.

Place, publisher, year, edition, pages
2016. Vol. 57, 30-37 p.
Keyword [en]
Lipopolysaccharide, Inflammation, Cytokines, Interleukin-6, Sickness behavior, Anxiety, Psychological condition, STAI, HADS, Predictor variables
National Category
Infectious Medicine Psychology
Identifiers
URN: urn:nbn:se:su:diva-134049DOI: 10.1016/j.bbi.2016.01.003ISI: 000383306200005PubMedID: 26790758Local ID: P-3367OAI: oai:DiVA.org:su-134049DiVA: diva2:975002
Available from: 2016-09-28 Created: 2016-09-28 Last updated: 2017-11-21Bibliographically approved

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