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  • 1.
    Christina Grape, R N
    et al.
    Stockholm University, Faculty of Social Sciences, Stress Research Institute.
    Theorell, Töres
    Stockholm University, Faculty of Social Sciences, Stress Research Institute.
    Wikström, Britt-Maj
    Ekman, Rolf
    Choir singing and fibrinogen. VEGF, cholecystokinin and motilin in IBS patients.2009In: Medical Hypotheses, ISSN 0306-9877, E-ISSN 1532-2777, Vol. 72, no 2, p. 223-5Article in journal (Refereed)
  • 2. Nehme, P. A.
    et al.
    Amaral, F.
    Lowden, Arne
    Stockholm University, Faculty of Social Sciences, Stress Research Institute.
    Skene, D. J.
    Cipolla-Neto, J.
    Moreno, Claudia R. C.
    Stockholm University, Faculty of Social Sciences, Stress Research Institute. University of São Paulo, Brazil.
    Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring2019In: Medical Hypotheses, ISSN 0306-9877, E-ISSN 1532-2777, Vol. 132, article id 109353Article in journal (Refereed)
    Abstract [en]

    Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring. It is therefore postulated that female night workers when pregnant may expose the offspring to unwanted health threats. This may be explained by the fact that melatonin is essential for regulating energy metabolism and can influence reproductive activity. Moreover, the circadian misalignment caused by shift work affects fertility and the fetus, increasing the risk of miscarriage, premature birth and low birth weight, phenomena observed in night workers. Thus, we hypothesize that light-induced melatonin suppression as a result of night work may alter intrauterine metabolic programming in pregnant women, potentially leading to metabolic disorders in their offspring.

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