There is a growing recognition of the need to examine religiousness and conduct research on its influence on acculturation and adjustment among ethnic minorities (Güngör et al. in Int J Behav Dev 36:367–373, 2012. doi:10.1177/0165025412448357). The present study compares Turkish minority youth in Bulgaria and Germany by examining relationships among religious identity, acculturation orientations (i.e., cultural maintenance and adoption) and acculturation outcomes (i.e., life satisfaction and socio-cultural adjustment to the Turkish and mainstream cultures). Participants were 161 youth in Bulgaria and 155 in Germany who completed measures on religious identity, acculturation orientations and adjustment. Results revealed that religious identity and Turkish culture maintenance are more important for Turkish-German, than for Turkish-Bulgarian youth. A multigroup path model showed that for both samples acculturation orientations partially mediated the link between religious identity and adjustment to the Turkish culture, whereas religious identity was directly related both to adjustment to the mainstream culture and to life satisfaction. Findings highlight the centrality of religious identity and Turkish domains of acculturation for positive adjustment outcomes for Turkish youth in Bulgaria and Germany.
Docetaxel has been the standard first-line therapy in metastatic castration resistant prostate cancer. The survival benefit is, however, limited by either primary or acquired resistance. In this study, Du145 prostate cancer cells were converted to docetaxel-resistant cells Du145-R and Du145-RB by in vitro culturing. Next generation RNAseq was employed to analyze these cell lines. Forty-two genes were identified to have acquired mutations after the resistance development, of which thirty-four were found to have mutations in published sequencing studies using prostate cancer samples from patients. Fourteen novel and 2 previously known fusion genes were inferred from the RNA-seq data, and 13 of these were validated by RT-PCR and/or re-sequencing. Four in-frame fusion transcripts could be transcribed into fusion proteins in stably transfected HEK293 cells, including MYH9-EIF3D and LDLR-RPL31P11, which were specific identified or up-regulated in the docetaxel resistant DU145 cells. A panel of 615 gene transcripts was identified to have significantly changed expression profile in the docetaxel resistant cells. These transcriptional changes have potential for further study as predictive biomarkers and as targets of docetaxel treatment.