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  • 1. Kramberger, Milica G.
    et al.
    Giske, Katarina
    Cavallin, Lena
    Kåreholt, Ingemar
    Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Jönköping University, Sweden.
    Andersson, Thomas
    Winblad, Bengt
    Jelic, Vesna
    Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort2017In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 128, no 9, p. 1575-1582Article in journal (Refereed)
    Abstract [en]

    Objective: The aim of the study was to describe the relationship between electroencephalographic (EEG) findings obtained by standardized visual analysis, subclinical white matter lesions (WML) and brain atrophy in a large memory clinic population.& para;& para;Methods: Patients with Alzheimer's disease (AD, n = 58), mild cognitive impairment (MCI, n = 141), subjective cognitive impairment (SCI, n = 194) had clinical, MRI based WML severity and regional atrophy assessments, and routine resting EEG recording. Background activity (BA) and episodic and continuous abnormalities were assessed visually in EEG.& para;& para;Results: WML (p = 0.006) and atrophy in medial temporal regions (MTA) (p = <0.001) were associated with slower BA in all diagnoses. WML were associated in SCI with total episodic EEG abnormalities (p = 0.03).& para;& para;Conclusions: EEG is associated with subclinical WML burden and cortical brain atrophy in a memory clinic population.& para;& para;Significance: Even the standard visually assessed EEG can complement a memory clinic diagnostic workup.

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