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  • 1.
    Ahlsten, Nanna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Martin-Matute, Belen
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Rhodium-catalysed isomerisation of allylic alcohols in water at ambient temperature2010Ingår i: Green Chemistry, ISSN 1463-9262, E-ISSN 1463-9270, Vol. 12, nr 9, s. 1628-1633Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An environmentally benign method for the transformation of allylic alcohols into carbonyl compounds is described. Using [Rh(COD(CH3CN)(2)]BF4 (2) in combination with 1,3,5-triaza-7-phosphaadamantane (PTA, 1) as the catalytic system in water results in a very fast redox isomerisation of a variety of secondary allylic alcohols at ambient temperature. Also, some primary allylic alcohols can be isomerised into the corresponding aldehydes. The active complex, which in some cases can be used in catalyst loadings as low as 0.5 mol%, is formed in situ from commercially available reagents. Based on deuterium labelling studies, a tentative mechanism involving metal-enone intermediates is presented.

  • 2.
    Buitrago, Elina
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Andersson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ryberg, Per
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    High Throughput Screening of a Catalyst Library for the Asymmetric Transfer Hydrogenation of Heteroaromatic Ketones: Formal Syntheses of (R)-Fluoxetine and (S)-Duloxetine2012Ingår i: ChemCatChem, ISSN 1867-3880, E-ISSN 1867-3899, Vol. 4, nr 12, s. 2082-2089Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A total of 21 amino acid based ligands including hydroxy amide, thioamide, and hydroxamic acid functionalities, respectively, were combined with [Ru(p-cymene)Cl2]2 and [RhCp*Cl2]2, and used as catalysts for the asymmetric transfer hydrogenation of four different heteroaromatic ketones in 2-propanol. The reactions were performed on a Chemspeed automated high-throughput screening robotic platform. Optimal catalysts were identified for the individual heterocyclic substrate classes. Based on these results, the formal syntheses of the antidepressant drugs (R)-fluoxetine and (S)-duloxetine were conducted by using the found catalysts in the key reaction step, which results in high isolated yields (94?%) and excellent product enantioselectivities (>99?% ee) of the formed 1,3-amino alcohols.

  • 3.
    Buitrago, Elina
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Andersson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ryberg, Per
    Aztra Zeneca, Global Process R&D, Södertälje, Sweden.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Selective reduction of heteroaromatic ketones: A combinatorial approach2011Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    The enantioselective reduction of prochiral ketones is a most productiveway towards enantio enriched secondary alcohols used in the preparation of biologically active compounds. There are numerous transition metal catalyzed methods for this transformation, particularly based on Ru(II)-and Rh(I)-complexes, but there is a demand for a larger substrate scope. Heteroaromatic ketones are traditionally more challenging substrates. Normally a catalyst is developed for one benchmark substrate, and asubstrate screen is made with the best performing catalyst. Using this methodology, there is a high probability that for different substrates, another catalyst could outperform the one used. We have executed a multiple screen, containing a variety of different ligands together with both Ru and Rh, and heteroaromatic ketones to fine-tune, and find the optimum catalyst depending on the substrate. The acquired information was used to synthesize known, biologically active compounds, where the key reduction steps were performed with high enantioselectivities and yields.

  • 4.
    Kovalenko, Oleksandr O.
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Huebner, Dennis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Tandem alpha-Alkylation/Asymmetric Transfer Hydrogenation of Acetophenones with Primary Alcohols2014Ingår i: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, nr 30, s. 6639-6642Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A tandem -alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and with use of [Ru(p-cymene)Cl-2](2) in combination with an amino acid hydroxyamide ligand, the chiral secondary alcohol products were isolated in moderate yields and in moderate to good enantiomeric excess (up to 89% ee).

  • 5.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Amidst the green Metal-catalyzed amide formation from carboxylic acids2012Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    This thesis describes novel methods for transition metal-catalyzed transformation of non-activated carboxylic acids to amides. It was found that 2-10 mol% of zirconium(IV) chloride or 10-20 mol% titanium(IV) isopropoxide catalyzed the formation of a range of secondary and tertiary amides in good to excellent yields (61-99%) in THF at 70-100°C, with molecular sieves present as water scavengers. The protocols proved to be suitable for gram scale preparation of amides, where a straight-forward work-up procedure was used for the isolation of the amide products. Furthermore, it was found that ammonium carbamates were suitable equivalents for gaseous ammonia and dimethylamine, in the group (IV) metal-catalyzed amidation of structurally different carboxylic acids, resulting in good to excellent yields (61-99%) of primary and N,N-dimethyl amides.

  • 6.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Group (IV) Metal-Catalyzed Direct Amidation: Synthesis and Mechanistic Considerations2015Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [sv]

    Amidbindningen är en kemisk enhet som utgör ryggraden i proteiner, och som även återfinns i en stor mängd läkemedelsmolekyler, polymera material som nylon och Kevlar, samt i tillsatser i livsmedelsindustrin, exempelvis aspartam. Amider produceras i enorma mängder varje år, och det är av stor vikt att utveckla miljövänliga och selektiva metoder för deras framställning. Denna avhandling behandlar direkt amidering av icke-aktiverade karboxylsyror och aminer med hjälp av katalytiska mängder metallkomplex, baserade på titan, zirkonium och hafnium. Den enda biprodukten från denna amideringsreaktion är vatten. Jämfört med de metoder som generellt används idag för amidsyntes, så är de presenterade metoderna avsevärt mer miljövänliga med avseende på toxicitet hos reagensen såväl som på mängden avfall som genereras. Dessutom redovisas här en katalytisk metod för syntes av primära och tertiära amider genom att använda olika karbamat som källa till gasformiga aminer, vilka annars kan vara praktiskt svåra att arbeta med. Preliminära resultat från en pågående mekanistisk studie av de zirkonium- och hafnium-katalyserade processerna är också inkluderade.

  • 7.
    Lundberg, Helena
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Catalytic α-Alkylation/Reduction of Ketones with Primary Alcohols To Furnish Secondary Alcohols2016Ingår i: Synthesis (Stuttgart), ISSN 0039-7881, E-ISSN 1437-210X, Vol. 48, nr 5, s. 644-652Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    The formation of secondary alcohol products via a tandem -alkylation/transfer hydrogenation of ketones with primary alcohols is a little explored reaction with unrealized potential for green synthesis. This review covers the current literature in the field, including asymmetric versions of the reaction, and outlines future possibilities and challenges for the methodology. 1 Introduction 2 Formation of Racemic Alcohols 3 Formation of Enantiomerically Enriched Alcohols 4 Conclusions

  • 8.
    Lundberg, Helena
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ruthenium-catalyzed asymmetric transfer hydrogenation of ketones in ethanol2011Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    A ruthenium catalyst formed in situ by combining [Ru(p-cymene)Cl2]2 and an amino acid hydroxy-amide was found to catalyze efficiently the asymmetric reduction of aryl alkyl ketones under transfer hydrogenation conditions using ethanol as the hydrogen donor. The secondary alcohol products were obtained in moderate to good yields and with good to excellent enantioselectivity (up to 97% ee).

  • 9.
    Lundberg, Helena
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ruthenium-catalyzed asymmetric transfer hydrogenation of ketones in ethanol2011Ingår i: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 52, nr 21, s. 2754-2758Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A ruthenium catalyst formed in situ by combining [Ru(p-cymene)Cl2]2 and an amino acid hydroxy-amide was found to catalyze efficiently the asymmetric reduction of aryl alkyl ketones under transfer hydrogenation conditions using ethanol as the hydrogen donor. The secondary alcohol products were obtained in moderate to good yields and with good to excellent enantioselectivity (up to 97% ee).

  • 10.
    Lundberg, Helena
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Hans, Adolfsson
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Hafnium-Catalyzed Direct Amide Formation at Room Temperature2015Ingår i: ACS Catalysis, ISSN 2155-5435, E-ISSN 2155-5435, Vol. 5, nr 6, s. 3271-3277Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Herein, the first example of a metal-catalyzed protocol for direct amidation of non-activated carboxylic acids at ambient temperature (26 °C) is presented. The mild reaction conditions give rise to high yields of a range of amides in reaction times as short as 90 minutes, employing a commercial hafnium complex, [Hf(Cp)2Cl2], as catalyst. Amino acids are transformed into their corresponding amides without racemization, and the catalyst displays full selectivity for the amidation of carboxylic acids over esters. Electronic properties of the carboxylic acids were found to have a strong influence on the rate of the amidation reaction, and the need for a balanced amount of molecular sieves was observed to be highly important for optimal reaction outcome.

  • 11.
    Lundberg, Helena
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Tinnis, Fredrik
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Direct Amide Coupling of Non-activated Carboxylic Acids and Amines Catalysed by Zirconium(IV) Chloride2012Ingår i: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 18, nr 13, s. 3822-3826Artikel i tidskrift (Refereegranskat)
  • 12.
    Lundberg, Helena
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Tinnis, Fredrik
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Titanium(IV) Isopropoxide as an Efficient Catalyst for Direct Amidation of Nonactivated Carboxylic Acids2012Ingår i: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, ISSN 0936-5214, E-ISSN 1437-2096, Vol. 23, nr 15, s. 2201-2204Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Secondary and tertiary amides are formed in high yields, in an efficient and environmentally benign titanium(IV) isopropoxide catalyzed direct amidation of carboxylic acids with primary and secondary amines.

  • 13.
    Lundberg, Helena
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Tinnis, Fredrik
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Selander, Nicklas
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Catalytic amide formation from non-activated carboxylic acids and amines2014Ingår i: Chemical Society Reviews, ISSN 0306-0012, E-ISSN 1460-4744, Vol. 43, nr 8, s. 2714-2742Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    The amide functionality is found in a wide variety of biological and synthetic structures such as proteins, polymers, pesticides and pharmaceuticals. Due to the fact that synthetic amides are still mainly produced by the aid of coupling reagents with poor atom-economy, the direct catalytic formation of amides from carboxylic acids and amines has become a field of emerging importance. A general, efficient and selective catalytic method for this transformation would meet well with the increasing demands for green chemistry procedures. This review covers catalytic and synthetically relevant methods for direct condensation of carboxylic acids and amines. A comprehensive overview of homogeneous and heterogeneous catalytic methods is presented, covering biocatalysts, Lewis acid catalysts based on boron and metals as well an assortment of other types of catalysts.

  • 14.
    Sahoo, Suman
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi, Avdelningen för strukturkemi.
    Lundberg, Helena
    Ahlsten, Nanna
    Zou, Xiaodong
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi, Avdelningen för strukturkemi.
    Martín-Matute, Belén
    Heterogeneous Rh-Catalyzed Reactions of Allylic Alcohols2009Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    The development of metal-catalyzed reactions that are atom-economical, environmentally benign, and highly selective and that take place under mild reaction conditions is of extreme importance. The isomerization of allylic alcohols to the corresponding carbonyl compounds can be catalyzed by transition metal complexes. We have shown before that this transformation involves the formation of metal enolates. When this isomerization is performed under homogeneous conditions in the presence of an electrophile, a new C-C bond is formed in a regioselective manner.

    1 Here, we present our studies towards the use of immobilized transition metal complexes as heterogeneous catalysts in tandem transformations of allylic alcohols. Different strategies and supports for the immobilization have been compared in this study.

  • 15.
    Sahoo, Suman
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för oorganisk kemi och strukturkemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Edén, Mattias
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för fysikalisk kemi.
    Ahlsten, Nanna
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Wan, Wei
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för oorganisk kemi och strukturkemi.
    Zou, Xiaodong
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för oorganisk kemi och strukturkemi.
    Martín-Matute, Belén
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Single Site Supported Cationic Rhodium(I) Complexes for the Selective Redox Isomerization of Allylic Alcohols2012Ingår i: ChemCatChem, ISSN 1867-3880, E-ISSN 1867-3899, Vol. 4, nr 2, s. 243-250Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The isomerization of allylic alcohols to carbonyl compounds by a heterogeneous rhodium complex is reported. Different silica material supports and catalyst/ligand systems were evaluated. The most efficient catalyst in terms of catalytic activity and stability was found to be a cationic rhodium(I) complex with sulfonated phosphine ligands anchored on a mesoporous aluminosilica AlSBA-15. The heterogeneous complex catalyzed the isomerization of a variety of allylic alcohols in excellent yields with very low catalyst loadings (0.5 mol %). The catalyst could be recycled without significant loss of activity or selectivity. The optimized catalyst was characterized by N2 sorption, powder X-ray diffraction, transmission electron microscopy, as well as solution and solid-state nuclear magnetic resonance, and Fourier Transform infrared spectroscopies.

  • 16.
    Shatskiy, Andrey
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Kivijärvi, Tove
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Tinnis, Fredrik
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Propargylic Ketones2015Ingår i: ChemCatChem, ISSN 1867-3880, E-ISSN 1867-3899, Vol. 7, nr 23, s. 3818-3821Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The asymmetric transfer hydrogenation of alpha,beta-propargyl ketones catalyzed by an in situ formed ruthenium-hydroxyamide complex was explored. The acetylenic alcohols were isolated in good to excellent yields with excellent ee values (typically >90%) after short reaction times at room temperature.

  • 17.
    Slagbrand, Tove
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ruthenium-Catalyzed Tandem-Isomerization/Asymmetric Transfer Hydrogenation of Allylic Alcohols2014Ingår i: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 20, nr 49, s. 16102-16106Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A one-pot procedure for the direct conversion of racemic allylic alcohols to enantiomerically enriched saturated alcohols is presented. The tandem-isomerization/asymmetric transfer hydrogenation process is efficiently catalyzed by [{Ru(p-cymene)Cl-2}(2)] in combination with the -amino acid hydroxyamide ligand 1, and performed under mild conditions in a mixture of ethanol and THF. The saturated alcohol products are isolated in good to excellent chemical yields and in enantiomeric excess up to 93%.

  • 18.
    Tinnis, Fredrik
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Direct Catalytic Formation of Primary and Tertiary Amides from Non-Activated Carboxylic Acids, Employing Carbamates as Amine Source2012Ingår i: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 354, nr 13, s. 2531-2536Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The operationally simple titanium(IV)- or zirconium(IV)-catalyzed direct amidation of non-activated carboxylic acids with ammonium carbamates generates primary, and tertiary N,N-dimethyl-substituted amides in good to excellent yields.

  • 19.
    Tinnis, Fredrik
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Kivijärvi, Tove
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Zirconium(IV) Chloride Catalyzed Amide Formation from Carboxylic Acids and Amines: N-Benzyl-2-(phenylthio)acetamide and (S)-tert-butyl-2-(benzylcarbamoyl)pyrrolidine-1-carboxylateManuskript (preprint) (Övrigt vetenskapligt)
  • 20.
    Tinnis, Fredrik
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Kivijärvi, Tove
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Hans, Adolfsson
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Zirconium(IV) chloride catalyzed amide formation from carboxylic acids and amines: N-Benzyl-2-(phenylthio)acetamide and (S)-tert-butyl 2-(benzylcarbamoyl)pyrrolidine-1-carboxylateIngår i: Organic Syntheses, ISSN 0078-6209Artikel i tidskrift (Refereegranskat)
  • 21.
    Tinnis, Fredrik
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Stridfeldt, Elin
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lundberg, Helena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Olofsson, Berit
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi. Stellenbosch University, South Africa.
    Metal-Free N-Arylation of Secondary Amides at Room Temperature2015Ingår i: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 17, nr 11, s. 2688-2691Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The arylation of secondary acyclic amides has been achieved with diaryliodonium salts under mild and metal-free conditions. The methodology has a wide scope, allows synthesis of tertiary amides with highly congested aryl moieties, and avoids the regioselectivity problems observed in reactions with (diacetoxyiodo)benzene.

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