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  • 1.
    Li, Yunxiang
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Yun, Yifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Bernin, Diana
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Edén, Mattias
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Gao, Feifei
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    De-agglomeration of IZM-2 zeolite crystals by post-synthetic treatment2016In: Microporous and Mesoporous Materials, ISSN 1387-1811, E-ISSN 1873-3093, Vol. 225, p. 185-191Article in journal (Refereed)
    Abstract [en]

    Highly intergrown nanocrystals are commonly observed in zeolite samples, and the densely packed agglomerates may result in small secondary porosity, which restricts the advantage of hierarchical structures. In this work we take IZM-2 zeolite as an example to demonstrate a post-treatment method with diluted hydrofluoric acid solution, which de-agglomerates intergrown zeolite nanocrystals and improves the secondary porosity. The treated samples preserve high crystallinity, similar framework composition and distinctively higher external surface area compared to the agglomerated ones. The results show that this treatment is an effective method for de-agglomeration of intergrown nanocrystals without affecting the original framework.

  • 2.
    Liang, Jie
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK). Peking University, People's Republic of China.
    Su, Jie
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Luo, Xiaodan
    Wang, Yingxia
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Chen, Hong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK). China University of Geosciences, People's Republic of China.
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Lin, Jianhua
    Sun, Junliang
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK). Peking University, People's Republic of China.
    A Crystalline Mesoporous Germanate with 48-Ring Channels for CO2 Separation2015In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 54, no 25, p. 7290-7294Article in journal (Refereed)
    Abstract [en]

    One of the challenges in materials science has been to prepare crystalline inorganic compounds with mesopores. Although several design strategies have been developed to address the challenge, expansion of pore sizes in inorganic materials is more difficult compared to that for metal-organic frameworks. Herein, we designed a novel mesoporous germanate PKU-17 with 3D 48 x 16 x 16-ring channels by introducing two large building units (Ge-10 and Ge-7 clusters) into the same framework. The key for this design strategy is the selection of 2-propanolamine (MIPA), which serves as the terminal species to promote the crystallization of Ge-7 clusters. Moreover, it is responsible for the coexistence of Ge-10 and Ge-7 clusters. To our knowledge, the discovery of PKU-17 sets a new record in pore sizes among germanates. It is also the first germanate that exhibits a good selectivity toward CO2 over N-2 and CH4.

  • 3. Liang, Jie
    et al.
    Su, Jie
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Wang, Yingxia
    Lin, Zhongjun
    Mu, Weijun
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zou, Ruqiang
    Liao, Fuhui
    Lin, Jianhua
    CHA-type zeolites with high boron content: Synthesis, structure and selective adsorption properties2014In: Microporous and Mesoporous Materials, ISSN 1387-1811, E-ISSN 1873-3093, Vol. 194, p. 97-105Article in journal (Refereed)
    Abstract [en]

    Borosilicate zeolites with CHA-type framework are synthesized hydrothermally by using N,N,N-trimethylcyclohexylammonium hydroxide as structure directing agent. The use of this cation induces an increase of boron content in the CHA-type zeolites, and the Si/B ratios of the as-synthesized samples is in the range of 11.8-6.9. Rietveld refinements of the calcinated samples reveal a contraction of unit cells with the increase of boron content, and the 8-ring opening window of cha cavity becomes narrower. B-11 MAS NMR shows that all the boron atoms are incorporated into the framework as tetrahedral BO4 units in the as-synthesized samples. The thermal stability of these CHA-type borosilicates decreases with the increase of boron content, and the framework can retain up to 800 degrees C. These borosilicates, with the BET surfaces of 583-632 m(2)/g, show a high adsorption capacity for H-2 at 77 K, 900 mmHg and a preferential adsorption for CO2 at 273 K. This selective adsorption property enables CHA-type borosilicates to be potential materials as CO2 adsorbent.

  • 4.
    Lin, Junzhong
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Liu, Leifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Ning, Yuan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Sun, Junliang
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Titanium incorporated hierarchical porous silicate synthesized using D4R as building blocksManuscript (preprint) (Other academic)
    Abstract [en]

    Hierarchical porous materials as catalyst have provoked great attention recent years considering that it can offer enhanced molecular diffusion and mass transfer during the reaction. Titanium containing hierarchical porous silicate material has been successfully synthesized in present work. Double-four-ring units were used as the basic building blocks to construct the desired material. Both micropores and mesopores were found in the as synthesized material. The local structure of incorporated titanium species was carefully studied using various characterization techniques, such as XPS, UV-vis, XANES and EXAFS. Tetrahedral coordinated titanium can be mostly found in the as synthesized material in this work, the distorted the local structure was further revealed by using EXAFS.

  • 5.
    Lin, Junzhong
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Liu, Leifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Yuan, Ning
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Sun, Junliang
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Synthesis of hierarchical MCM-22 zeolite via a swelling and pillaring approachManuscript (preprint) (Other academic)
    Abstract [en]

    Zeolites are type of microporous crystalline material which have been widely used in various aspects of industry, such as separation, adsorption, and catalysis. However, great diffusion limitation can be provoked due to small pore size of mircoporus framework in catalytic reactions. Hierarchical zeolites have been proved to be a successful alternative to solve the diffusion problem. Particularly, the synthesis of hierarchical porous zeolite by swelling and pillaring lamellar MWW zeolitic precursor has been proved as an efficient approach to solve the diffusion limitations in the catalytic reactions. In this work, hierarchical MWW zeolite has been synthesized by swelling and pillaring of lamellar MWW zeolitic precursor (MCM-22) using D4R building units. The synthesis procedure has been carefully studied by various characterization methods, such as PXRD, TEM, N2 adsorption-desorption and etc.

  • 6. Liu, Ben
    et al.
    Mosa, Islam M.
    Song, Wenqiao
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Kuo, Chung-Hao
    Rusling, James F.
    Suib, Steven L.
    He, Jie
    Unconventional structural and morphological transitions of nanosheets, nanoflakes and nanorods of AuNP@MnO22016In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 4, no 17, p. 6447-6455Article in journal (Refereed)
    Abstract [en]

    Two-dimensional (2-D) layered inorganic materials with ultra-high surface area and mechanical strength have shown impressive photo-/electro-catalytic activities. We herein report a facile synthetic strategy to grow monodispersed 2-D MnO2 nanosheet on an individual gold nanoparticle (AuNP@MnO2 nanosheet), and demonstrate that the strongly interacted AuNP and MnO2 nanosheet could greatly improve the electrocatalytic activity of the MnOx family for electrocatalytic oxygen reduction reactions (ORRs). AuNP@MnO2 nanosheets were prepared using a hydrothermal reduction of KMnO4 by citrate ligands capped on AuNPs. Because of the metastability of the layered MnO2 nanosheets, we observed unconventional structural and morphological transitions of amorphous MnO2 nanosheets to delta-MnO2 nanoflakes, and eventually to alpha-MnO2 nanorods under hydrothermal conditions. The layered MnO2 nanosheets underwent a structural expansion to nanoflakes before the curling and re-folding of layered MnO2 nanosheets occurred. The intermediate states and structural transitions via a layer compression, for the first time, were experimentally recorded at a single-NP scale using electron microscopy. Moreover, we found the electrocatalytic activity of AuNP@MnO2 nanosheets was enhanced roughly 30-40 times, compared to that of pure MnO2 nanosheets and AuNPs. The strong interaction of metal-oxide interfaces (MnO2 nanosheets and AuNPs) was likely responsible for the improved electrocatalytic activity. This interaction of MnO2 and AuNPs was weakened in the course of hydrothermal treatment where partially positively charged Au+ was reduced at elevated temperatures, accompanying with the decrease of ORR activity. This insight into the effect of topological nanostructures and metal-oxide interactions on the electrocatalytic performance of the MnOx family is believed to illustrate an alternative pathway to develop new efficient electrocatalysts.

  • 7. Liu, Ben
    et al.
    Yao, Huiqin
    Daniels, Robert A.
    Song, Wenqiao
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Jin, Lei
    Suib, Steven L.
    He, Jie
    A facile synthesis of Fe3C@mesoporous carbon nitride nanospheres with superior electrocatalytic activity2016In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 8, no 10, p. 5441-5445Article in journal (Refereed)
    Abstract [en]

    We report a colloidal amphiphile-templating approach to preparing nanosized Fe3C encapsulated within mesoporous nitrogen-doped carbon nanospheres (Fe3C@mCN). The obtained Fe3C@mCN hybrids having a high surface area and ultrafine Fe3C nanocrystals exhibited superior activity and durability for oxygen reduction.

  • 8. Liu, Kai
    et al.
    Bai, Yaocai
    Zhang, Lei
    Yang, Zhongbo
    Fan, Qikui
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Yin, Yadong
    Gao, Chuanbo
    Porous Au-Ag Nanospheres with High-Density and Highly Accessible Hotspots for SERS Analysis2016In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 16, no 6, p. 3675-3681Article in journal (Refereed)
    Abstract [en]

    Colloidal plasmonic metal nanoparticles have enabled surface-enhanced Raman scattering (SERS) for a variety of analytical applications. While great efforts have been made to create hotspots for amplifying Raman signals, it remains a great challenge to ensure their high density and accessibility for improved sensitivity of the analysis. Here we report a dealloying process for the fabrication of porous Au-Ag alloy nanoparticles containing abundant inherent hotspots, which were encased in ultrathin hollow silica shells so that the need of conventional organic capping ligands for stabilization is eliminated, producing colloidal plasmonic nanoparticles with clean surface and thus high accessibility of the hotspots. As a result, these novel nanostructures show excellent SERS activity with an enhancement factor of similar to 1.3 x 10(7) on a single particle basis (off-resonant condition), promising high applicability in many SERS-based analytical and biomedical applications.

  • 9.
    Verho, Oscar
    et al.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Gao, Feifei
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Johnston, Eric V.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Wan, Wei
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Nagendiran, Anuja
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Bäckvall, Jan-Erling
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Mesoporous silica nanoparticles applied as a support for Pd and Au nanocatalysts in cycloisomerization reactions2014In: APL materials, ISSN 2166-532X, Vol. 2, no 11, p. 113316-Article in journal (Refereed)
    Abstract [en]

    Ultra-small mesoporous silica nanoparticles (MSNs) have been synthesized at room temperature with particle sizes ranging from 28 to 45 nm. These MSNs have been employed as heterogeneous supports for palladium and gold nanocatalysts. The colloidal nature of the MSNs is highly useful for catalytic applications as it allows for better mass transfer properties and a more uniform distribution of the nanocatalysts in solution. The two nanocatalysts were evaluated in the cycloisomerization of alkynoic acids and demonstrated to produce the corresponding alkylidene lactones in good to excellent yields under mild conditions. In addition to their high activity, the catalysts exhibit low degree of metal leaching and straight-forward recycling, which highlight the practical utility of MSNs as supports for nanocatalysts. (C) 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.

  • 10.
    Verho, Oscar
    et al.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Gustafson, Karl P. J.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Nagendiran, Anuja
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Bäckvall, Jan-E.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Application of Pd Nanoparticles Supported on Mesoporous Hollow Silica Nanospheres for the Efficient and Selective Semihydrogenation of Alkynes2016In: ChemCatChem, ISSN 1867-3880, E-ISSN 1867-3899, Vol. 8, no 4, p. 773-778Article in journal (Refereed)
    Abstract [en]

    Herein, the preparation of a heterogeneous catalyst consisting of 1-2nm sized Pd nanoparticles supported on amino-functionalized mesoporous hollow silica nanospheres and its use for the semihydrogenation of mono- and disubstituted alkynes is reported. By utilizing this Pd nanocatalyst together with the green poisoning agent DMSO, high yields of the desired alkenes could be achieved, while suppressing the degree of over-reduction to alkanes. To our delight, the Pd nanocatalyst displayed remarkable chemoselectivity towards the alkyne moiety, allowing the transformation to be carried out in the presence of other reducible functionalities, such as halogens, carbonyl, and nitro groups.

  • 11.
    Yao, Qingxia
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Bermejo Gómez, Antonio
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Su, Jie
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Pascanu, Vlad
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Yun, Yifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Chen, Hong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Liu, Leifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Abdelhamid, Hani Nasser
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Martin-Matute, Belén
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Series of Highly Stable Isoreticular Lanthanide Metal-Organic Frameworks with Expanding Pore Size and Tunable Luminescent Properties2015In: Chemistry of Materials, ISSN 0897-4756, E-ISSN 1520-5002, Vol. 27, no 15, p. 5332-5339Article in journal (Refereed)
    Abstract [en]

    A series of highly porous isoreticular lanthanide-based metal organic frameworks (LnMOFs) denoted as SUMOE-7I to SUMOE-7IV (SU = Stockholm University; Ln = La, Ce, Pr, Nd, Sm, Eu, and Gd) have been synthesized using tritopic carboxylates as the organic linkers. The SUMOF-7 materials display one-dimensional pseudohexagonal channels with the pore diameter gradually enlarged from 8.4 to 23.9 angstrom, as a result of increasing sizes of the organic linkers. The structures have been solved by single crystal X-ray diffraction or rotation electron diffraction (RED) combined with powder X-ray diffraction (PXRD). The SUMOF-7 materials exhibit robust architectures with permanent porosity. More importantly, they exhibit exceptionally high thermal and chemical stability. We show that, by inclusion of organic dye molecules, the luminescence properties of the MOFs can be elaborated and modulated, leading to promising applications in sensing and optics.

  • 12.
    Yao, Qingxia
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Inorganic and Structural Chemistry.
    Bermejo Gómez, Antonio
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Su, Jie
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Inorganic and Structural Chemistry.
    Pascanu, Vlad
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Yun, Yifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zheng, Haoquan
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Inorganic and Structural Chemistry.
    Chen, Hong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Inorganic and Structural Chemistry.
    Liu, Leifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Inorganic and Structural Chemistry.
    Martín-Matute, Belén
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Highly porous isoreticular lanthanide metal-organic frameworksManuscript (preprint) (Other academic)
    Abstract [en]

    As an emerging type of porous materials, metal–organic frameworks (MOFs) have the advantages over conventional inorganic porous materials in that their structures and functions are systematically and predictably designable. Isoreticular expansion is an efficient way for systematic design and control of pore size and shape for MOFs. By using our proposed strategy, a series of highly porous isoreticular lanthanide-based metal-organic frameworks with systematic pore apertures has been obtained, which afford an isoreticular series of MIL-103 structures (termed SUMOF-7I to IV) with pore apertures ranging from 7.2 Å to 23 Å. These materials demonstrated exhibit robust architectures with permanent porosity, and exceptional thermal stability and chemical stability in various solvents. The combination of luminescence property and significant porosity of these MOFs enable them as a potential platform for multifunctional purpose.

  • 13.
    Zheng, Haoquan
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK). Shaanxi University, China.
    Svengren, Henrik
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Huang, Zhehao
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Yang, Zhiyuan
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Johnsson, Mats
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Hollow titania spheres loaded with noble metal nanoparticles for photocatalytic water oxidation2018In: Microporous and Mesoporous Materials, ISSN 1387-1811, E-ISSN 1873-3093, Vol. 264, p. 147-150Article in journal (Refereed)
    Abstract [en]

    A synthesis procedure for fabrication of hollow TiO2 spheres of mixed anatase/rutile composition loaded with noble metal nanoparticles (Au, Pt, Pd) is proposed. The materials demonstrated to be functioning photocatalysts for water oxidation. In particular nanoparticles loaded with Pd and Pt showed good catalytic activity in comparison to commercial TiO2 P25.

  • 14.
    Zheng, Haoquan
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Tai, Cheuk-Wai
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Su, Jie
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Gao, Feifei
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs2015In: Dalton Transactions, ISSN 1477-9226, E-ISSN 1477-9234, Vol. 44, no 46, p. 20186-20192Article in journal (Refereed)
    Abstract [en]

    Mesoporous silica has emerged as one of the most promising carriers for drug delivery systems. However, the synthesis of ultra-small mesoporous silica nanoparticles (UMSNs) and their application in drug delivery remains a significant challenge. Here, spherical UMSNs (similar to 25 nm) have been synthesized and tested as drug carriers. Anti-cancer drugs mitoxantrone (MX), doxorubicin (DOX) and methotrexate (MTX) have been utilized as model drugs. The pH-responsive drug delivery system can be constructed based on electrostatic interactions between carriers and drug molecules. The UMSNs could store drugs under physiological conditions and release them under acidic conditions. Different pH-responsive release profiles were obtained in phosphate buffer solutions (PBSs) at the designed pH values (from 4.0 to 7.4). MX and DOX can be used in the pH-responsive delivery system, while MTX cannot be used. Furthermore, we found that the physiological stabilities of these drug molecules in UMSNs are in a decreasing order MX > DOX > MTX, which follows the order of their isoelectric point (pI) values.

  • 15.
    Zheng, Haoquan
    et al.
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Zhang, Yuning
    Liu, Leifeng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Wan, Wei
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Guo, Peng
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Nyström, Andreas M.
    Zou, Xiaodong
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    One-pot Synthesis of Metal Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery2016In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 138, no 3, p. 962-968Article in journal (Refereed)
    Abstract [en]

    Many medical and chemical applications require target molecules to be delivered in a controlled manner at precise locations. Metal-organic frameworks (MOFs) have high porosity, large surface area, and tunable functionality and are promising carriers for such purposes. Current approaches for incorporating target molecules are based on multistep postfunctionalization. Here, we report a novel approach that combines MOF synthesis and molecule encapsulation in a one-pot process. We demonstrate that large drug and dye molecules can be encapsulated in zeolitic imidazolate framework (ZIF) crystals. The molecules are homogeneously distributed within the crystals, and their loadings can be tuned. We show that ZIF-8 crystals loaded with the anticancer drug doxorubicin (DOX) are efficient drug delivery vehicles in cancer therapy using pH-responsive release. Their efficacy on breast cancer cell lines is higher than that of free DOX. Our one-pot process opens new possibilities to construct multifunctional delivery systems for a wide range of applications.

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