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  • 1.
    Athanasiadou, Maria
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Marsh, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Asplund, Lillemor
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Gas chromatography and mass spectrometry of methoxylated polybrominated diphenyl ethers (MeO-PBDEs).2006Inngår i: J Mass Spectrom, ISSN 1076-5174, Vol. 41, nr 6, s. 790-801Artikkel i tidsskrift (Annet vitenskapelig)
  • 2.
    Cuadra, Steven N.
    et al.
    University of Nicaragua-Managua.
    Linderholm, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Jakobsson, Kristina
    Lunds universitet.
    Persistent organochlorine pollutants in children working at a waste-disposal site and in young females with high fish consumption in Managua, Nicaragua2006Inngår i: Ambio, ISSN 0044-7447, E-ISSN 1654-7209, Vol. 35, nr 3, s. 109-116Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this study was to assess persistent organochlorine pollutant (POP) levels in serum collected from children (11-15 years old) working and sometimes also living at the municipal waste-disposal site in Managua, located at the shore of Lake Managua, and in nonworking children living both nearby and also far away from the waste-disposal site. The influence of fish consumption was further evaluated by assessing POPS levels in serum from young women (15-24 years old) with markedly different patterns of fish consumption from Lake Managua. 2,2-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (4,4’-DDT) and 2,2-bis(4-chlorophenyl)-1,1-dichloro-ethene (4,4-DDE), T-hexachlorocyclohexane (gamma-HCH), polychlorinated biphenyls, pentachlorophenol, and polychlorobiphenylols were quantified in all samples. In general, the levels observed were higher than those reported in children from developed countries, such as Germany and United States. Toxaphene, aldrin, dieldrin, and beta-HCH could not be identified in any sample. The children working at the waste-disposal site had higher levels of POPS compared with the nonworking reference groups. In children not working, there were also gradients for several POPs, according to vicinity to the waste-disposal site. Moreover, in children, as well as in young women, there were gradients according to fish consumption. The most abundant component was 4,4-DDE, but at levels still lower than those reported in children from malarious areas with a history of recent or current application of 4,4-DDT for vector control.

  • 3. Dosis, Ioannis
    et al.
    Kamarianos, Athanasios
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Karamanlis, Xanthippos
    Polybrominated diphenyl ethers (PBDEs) in marine sediment of Thermaikos Gulf, Greece2011Inngår i: International Journal of Environmental Analytical Chemistry, ISSN 0306-7319, E-ISSN 1029-0397, Vol. 91, nr 12, s. 1151-1165Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Polybrominated diphenyl ether (PBDE) concentrations were determined in marine sediment samples collected from 7 different locations around Thermaikos Gulf in north Greece. PBDEs were detected in all sampling sites and their average total concentration (Sigma PBDEs) ranged from 0.26 to 4.92 ng g(-1) d.w. Concentrations were an order of magnitude higher in locations outlining the inner part of the Gulf, which were also closer to industrial areas, sewage treatment plant discharges, the city's harbour and landfill area. These findings suggest pollution in the aquatic ecosystem from industrial and urban activities in the area. Congener profiles exhibit predominance of BDE-209, while concentrations of other PBDE congeners were usually lower, when compared to similar studies from other countries globally, indicating that Thermaikos Gulf is among the low-polluted areas. Statistical analysis showed significant differences among the higher polluted sampling stations. Statistically significant differences also existed between sampling stations with high and low PBDE concentrations. Correlations between congeners suggested local contamination sources; however, specific point sources of pollution were not established.

  • 4.
    Fängström, Britta
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bignert, Anders
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Grandjean, Philippe
    Weihe, P
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Polybrominated diphenyl ethers and traditional organochlorine pollutants in fulmars (Fulmarus glacialis) from the Faroe Islands2005Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 60, nr 7, s. 836-843Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The observed high-level burdens of organohalogens among the residents of the Faroe Islands, needs to be explained. Long-finned pilot whale (Globicephala melas) blubber and meat are known sources of environmental exposure. The present study focus on the organohalogen contamination of the fulmar (Fulmarus glacialis). The compounds quantified in fulmar muscle, fat, and egg are PCBs, DDTs, hexachlorobenzene (HCB), and polybrominated diphenyl ethers (PBDEs). The dominating pollutants are the 4,4′-DDT metabolite 4,4′-DDE and the two PCB congeners, CB-153 and CB-180, which are present in geometric mean concentrations of 7100, 4700 and 2500 ng/g lipid weight (l.w.), respectively, in adult fulmar muscle. 4,4′-DDT and HCB concentrations are approximately 250 ng/g l.w., each. Concentrations in the eggs are about 50% of the fulmar muscle levels, due to differences in lipid amounts, 4% in muscle and 10% in the eggs, the exposure contribution on a fresh weight basis is almost the same. As a result, both the egg and the adult fulmar muscle may lead to a significant exposure risk, if consumed by humans.

    BDE-153, the most abundant PBDE congener in fulmar muscle, with a geometric mean concentration of 6.5 ng/g l.w., is much lower than the individual PCB congeners and 4,4′-DDE concentrations. In the adult fulmar muscle, the relative PBDE congener pattern is different from that previously observed in biota, with BDE-153 and BDE-154 as the dominating congeners, rather than BDE-47. In contrast, BDE-47 is the most abundant congener in juvenile muscle and subcutaneous fat. The ∑PBDE concentrations are almost the same in egg, muscle (adult and juvenile) and subcutaneous fat (juvenile). For the polybrominated biphenyl (BB-153) the concentrations are considerably higher in the adult bird and egg than in the juvenile bird; this is also seen for the PCB and 4,4′-DDE concentrations.

    PCB concentrations found in fulmar egg and muscle are in the same range as seen in the pilot whale, i.e. 590–5700 ng/g l.w. for CB-153. Hence humans are also exposed to PCBs at a reasonable degree via intake of fulmar and/or fulmar egg and not only via pilot whale blubber.

  • 5.
    Fängström, Britta
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Weihe, Pál
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Hydroxylated PCB Metabolites in Non-hatched Fulmar Eggs from the Faroe Islands2005Inngår i: Ambio, ISSN 0044-7447, E-ISSN 1654-7209, Vol. 3, nr 34, s. 184-187Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Thirty-six polychlorinated biphenylols (OH-PCBs) conge-ners were characterized in Fulmar (Fulmarus glacialis) eggs collected from the Faroe Islands. The seven most abundant congeners were quantified in 19 samples, and the XOH-PCB concentrations ranged between 0.92 and 4.0 ng g 1 fresh weight (f.w.). These eggs constitute a part of the traditional diet for at least a part of the population on the Faroe Islands and may contribute to the high levels of these contaminants found in the blood of pregnant Faroese women. Because the metabolites are present in the nonhatched fulmar egg, it is concluded that the OH-PCBs are transferred to the egg before laying. High levels, 3300- 18 000 ng g-1 l.w., of 2polychlorinated biphenyls (PCB) were determined in the fulmar eggs, which are a consider-able source for human exposure. The high PCB levels are a source for metabolic formation of hydroxylated PCBs.

  • 6.
    Granelli, Lisa
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Eriksson, Johan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Reductive debromination of nonabrominated diphenyl ethers by sodium borohydride and identification of octabrominated diphenyl ether products2011Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 82, nr 6, s. 839-846Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A method was developed to study reductive transformation of highly brominated diphenyl ethers (BDEs). The method development is a part of a broader project where it will be used to determine the susceptibility of environmental pollutants to reductive conditions, in an attempt to create a scheme for determination of chemical’s persistence. This paper focuses on identification of octabrominated diphenyl ether transformation products from reductive debromination of the three nonabrominated diphenyl congeners (nonaBDE), BDE-206, -207 and -208. Sodium borohydride was used to explore the reductive debromination of the nonaBDEs. The transformation products were collected at two time-points and identified products were quantified by GC–MS. The reduction of the nonaBDEs lead primarily to debrominated products, mainly octaBDEs. The three nonabrominated DEs gave isomer-related transformation product patterns. BDE-207 and BDE-208 showed a propensity for ortho-debromination in the initial reaction step, while no discrimination between initial debromination positions was seen for BDE-206. All three nonabrominated DEs displayed a preferred initial debromination on the fully brominated DE ring.

  • 7.
    Gómara, Belén
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK). CSIC, Spain.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Quintanilla-López, Jesús Eduardo
    José González, María
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Polychlorinated biphenyls and their hydroxylated metabolites in placenta from Madrid mothers2012Inngår i: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 19, nr 1, s. 139-147Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction Concentrations and congener profiles of polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in placenta samples from a Madrid population (Spain) are reported. Structure dependent retentions of OH-PCBs are known to occur in both humans and wildlife, making it of interest to assess placental transfer of both parent compounds and their metabolites to the developing foetus.

    Results The Sigma PCB concentrations found in placenta samples were in the range 943-4,331 pg/g fresh weight (f.w.), and their hydroxylated metabolites showed a 20-time lower concentration level (53-261 pg/g f.w.). The PCB profiles were surprisingly dominated by CB-52 and CB-101 accounting for more than 44% of the total PCB concentration. This is indicating a source of exposure that is not yet identified. The OH-PCB profiles were dominated by 4-OH-CB187 and 4-OH-CB146, representing >50% of the Sigma OH-PCB concentration of the placenta samples. Statistical analysis of the data revealed strong correlations between the PCB congeners, among some OH-PCBs, and between OH-PCB metabolites with a meta- and para- substitution pattern. Both PCB and OH-PCB concentrations presented homogeneous distribution, what allowed the establishment of a partial least squares model that correlated the concentrations of OH-PCB with those of PCBs in placenta samples. In addition, causal correlations were observed between the concentrations of OH-PCBs and those of their corresponding PCB precursors.

  • 8.
    Hovander, Lotta
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Linderholm, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bignert, Anders
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Fängström, Britta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Kocan, Anton
    Petrik, Jan
    Trnovec, Tomas
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Levels of PCBs and their metabolites in the serum of residents of a highly contaminated area in eastern Slovakia2006Inngår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 40, nr 12, s. 3696-3703Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The over-riding aim of the present investigation was to obtain information concerning exposure that can be used as a basis for studies on the health of individuals residing in the Michalovce area of eastern Slovakia which is heavily contaminated by polychlorinated biphenyls (PCBs). Accordingly, this work focused on determination of serum concentrations of hydroxylated (OH-PCBs) and methylsulfonyl-substituted (MeSO2-PCBs) metabolites of PCBs. One hundred and twenty-two men and women, 20-59 years of age, living in the contaminated area and 175 from the control Stropkov/Svidnik district were selected randomly from 2047 sampled individuals. Following a specially designed cleanup, the levels of various congeners of OH-PCBs and MeSO2-PCBs in their serum were quantitated by gas chromatography and mass spectrometry, with comparison to authentic reference standards. The median concentrations of PCB congeners and their OH-PCB and MeSO2-PCB metabolites were 2-3-fold higher in residents of Michalovce than in the control region. The levels of certain OH-PCB metabolites were in the same high range as those of individual PCB congeners, whereas the MeSO2-PCB levels were significantly lower. The PCB and their metabolites were present at slightly higher concentrations in men than in women, and the serum levels of PCBs and MeSO2-PCBs increased with increasing age. Thus, the environmental contamination resulting from previous industrial production of PCBs has led to elevated concentrations of PCBs and their metabolites in the serum of individuals living in the Michalovce area.

  • 9. Jacobsson, Gerd
    et al.
    Roos, Anna
    Bisther, Mia
    Athanasiadou, Maria
    Stockholms universitet.
    Concentrations of PCBs and their metabolites and some pesticides in otter *Lutra lutra( scats from two areas of Sweden2008Inngår i: European Otter 2008 Workshop: EOW´08, 2008Konferansepaper (Annet (populærvitenskap, debatt, mm))
  • 10.
    Jakobsson, K
    et al.
    Department of Occupational and Environmental Medicine, Lund University, Sweden.
    Fång, J
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Rignell-Hydbom, A
    Department of Occupational and Environmental Medicine, Lund University, Sweden.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Polybrominated diphenyl ethers (PBDEs) in maternal serum, umbilicalcord blood, colostrum and mature breast milk2010Konferansepaper (Annet vitenskapelig)
  • 11. Jakobsson, K.
    et al.
    Fång, Johan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Rignell-Hydbom, A.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Polybrominated diphenyl ethers in maternal serum, umbilical cord serum, colostrum and mature breast milk: Insights from a pilot study and the literature2012Inngår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 47, s. 121-130Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Human serum and mother's milk are frequently used to assess exposure to polybrominated diphenyl ethers (PBDEs), including transplacental transfer to the foetus. However, little is known about the kinetics of PBDEs, especially the highly brominated BDE congeners.

    In this pilot study, maternal serum samples were collected from 10 women at delivery and five to six weeks post partum. Umbilical serum was also obtained. Milk was donated two to five days, and five to six weeks after delivery. The amount of PBDEs in these samples was determined using liquid–liquid extraction and GC/MS.

    Low, moderately and highly brominated diphenyl ethers were present in umbilical cord serum, indicating placental transfer. The lipid-adjusted levels of BDE-47, BDE-207 and BDE-209 were similar in maternal and umbilical cord serum, whereas the cord serum levels for the penta- to octa-BDEs quantified were lower than in maternal serum.

    Marked changes were seen in the congener pattern in breast milk during the first month of lactation, whereas maternal serum levels did not change significantly. The general pattern was an enrichment of low to moderately brominated congeners (i.e. from BDE-17 to BDE-154, with the exception of BDE-28) in colostrum compared with maternal serum. In contrast, more highly brominated congeners were found at similar, or lower levels in colostrum than in maternal serum. After the transition from colostrum to mature milk, the levels of BDE-153 and BDE-209 were substantially reduced, and BDE‐209 was below the limit of detection in 6 out of 9 samples.

    A literature review on the design and reporting of studies on the transfer of PBDEs from mother to infant revealed a lack of transparency in many cases. The use of the recently published STROBE-ME guidelines is therefore recommended.

  • 12. Langer, Pavel
    et al.
    Kocan, Anton
    Tajtáková, Mária
    Rádiková, Zofia
    Petrík, Ján
    Koska, Juraj
    Ksinantová, Lucia
    Imrich, Richard
    Hucková, Miloslava
    Chovancová, Jana
    Drobná, Beáta
    Jursa, Stanislav
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Hovander, Lotta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Gasperá­ková, Daniela
    Trnovec, Tomás
    Seböková, Elena
    Klimes, Iwar
    Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary-thyroid interrelations.2007Inngår i: Chemosphere, ISSN 0045-6535, Vol. 70, nr 1, s. 110-118Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In polluted district of Michalovce in East Slovakia (POLL) and two districts with background pollution (BCGR) 2046 adults (834 males and 1212 females aged 20-75 years) were examined. Serum levels of thyrotropin (TSH), free thyroxine (FT4), total triiodothyronine (TT3) and antithyroperoxidase antibodies (TPOab) were estimated by electrochemiluminiscent assay and also these of 15 polychlorinated biphenyl congeners (PCBs), p,p'-DDE, p,p'-DDT, hexachlorobenzene (HCB) and hexachlorocyclohexane were measured by high resolution gas chromatography/mass spectrometry. In addition, also dioxins, furans, coplanar- and mono-ortho-PCBs as well as selected hydroxylated and methylsulphonated PCBs and DDE metabolites were measured by appropriate methods based on gas chromatography/mass spectrometry principle. In POLL significantly higher levels of all organochlorines were found than these in BCGR. When pooled values from both areas were stratified in terms of PCBs level and treated as continuous variables, positive association of PCBs with FT4 and TT3 was found, the latter two being also mutually associated. However, within the category of PCBs level <530ng/glipid (n=232) the association between PCBs and both the FT4 (p<0.09) and TT3 (p<0.03) was negative and any association of these was not found within the category of PCBs level of 531-1000ng/g (n=691). In contrast, in the category of 531-2000ng/g (n=1307) positive association appeared between PCBs and FT4 (p<0.001) as well as TT3 (p<0.05). Highly significant association of PCBs with FT4 (p<0.001) was further found in the categories with PCBs level of 1001-101414ng/g (n=1307) and 2001-101414 (n=1123), while significant association with TT3 was observed only in the category of 531-2000ng/g. Such findings suggest possible threshold level in positive effect of PCBs on FT4 and TT3 level which seems to be individual and located somewhere around the PCBs level of 1000ng/g. However, highly significant negative association of both FT4 and TT3 with TSH was found in each of above indicated PCBs categories. Considerable difference in FT4 and TT3 level between large groups of subjects with the same range of PCBs level was also found suggesting different individual susceptibility to the effects of organochlorines. Among a total of 26 cases from POLL with very low TSH level (<0.5mUl(-1)) 13 cases showed very high level of PCBs, FT4 and TT3, thus supporting a hypothesis on a novel sporadic form of high PCBs related peripheral subclinical hyperthyroidism possibly resulting from the long-term disruption of equilibrium between bound and free thyroxine in plasma by high PCBs level followed by a striking inhibition of TSH release from the pituitary.

  • 13. Langer, Pavel
    et al.
    Tajtáková, Mária
    Kocan, Anton
    Petrík, Ján
    Koska, Juraj
    Ksinantová, Lucia
    Rádiková, Zofia
    Ukropec, Jozef
    Imrich, Richard
    Hucková, Miloslava
    Chovancová, Jana
    Drobná, Beáta
    Jursa, Stanislav
    Vlcek, Miroslav
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Hovander, Lotta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Shishiba, Yoshimasa
    Trnovec, Tomás
    Seböková, Elena
    Klimes, Iwar
    Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin.2007Inngår i: Chemosphere, ISSN 0045-6535, Vol. 69, nr 1, s. 118-27Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We examined 2,046 adults (834 males and 1,212 females aged 20-75 years) from polluted district in East Slovakia (POLL) and two neighboring upstream and upwind located districts of background pollution (BCGR). By ultrasound we estimated the thyroid volume (ThV), hypoechogenicity (HYE), nodules and cysts. Serum levels of thyrotropin (TSH), thyroperoxidase antibodies (TPOab) and thyroglobulin were estimated by electrochemiluminiscent assay and these of 15 PCB congeners, p,p'-DDE, p,p'-DDT, hexachlorobenzene (HCB) and hexachlorocyclohexane by high-resolution gas chromatography. In 320 subjects also selected hydroxylated and methylsulfonated PCB metabolites, polychlorinated dibenzo-dioxins (PCDDs), -furans (PCDFs), five dioxin-like coplanar and eight mono-ortho PCB congeners were estimated. Urinary iodine was measured by automatic microplate method. Reciprocal positive association was found between three major POPs (PCBs, DDE and HCB), the levels of these and also PCDDs plus PCDFs in polluted area being considerably higher than in background pollution area. ThV in groups of males and females from POLL with high PCBs level was significantly higher (p<0.001 by t-test) then in age and sex matched groups from BCGR with low PCBs level. In 1,048 males and females aged <60 years with serum PCBs level >1,000 ng g(-1) lipid (median=1,756 ng g(-1)) a significant effect of age on ThV was found (p<0.01 by ANOVA), while in 921 respective subjects with PCBs level <1,000 ng g(-1) (median=661 ng g(-1)) it was not. These findings supported the view on the additional effect of PCBs on ThV other than that of age. Since the urinary iodine in both districts showed optimal range, any interfering effect of unsatisfactory iodine intake on ThV may be excluded. The frequency of autoimmune thyroiditis signs such as HYE, increased serum level of TPOab and TSH resulting in subclinical or overt thyroid hypofunction was positively associated with sex, age and organochlorine levels. The increase of such frequency in males with POPs levels was much more abrupt than that in females. No considerable differences in the frequency of thyroid nodules as related to PCBs level were found.

  • 14.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Jakobsson, Kristina
    Lunds universitet.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Persistent organic pollutants in children working and living at urban waste disposal sites in Nicaragua and Bangladesh2010Konferansepaper (Annet vitenskapelig)
  • 15.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Masuda, Y
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    PCB and PCB metabolites in serum from Yusho patients 37 years after the accident2007Inngår i: Organohalogen Compounds: Yusho and Yucheng-clinical and epidimiological aspect, 2007, s. 2141-2144Konferansepaper (Fagfellevurdert)
  • 16.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Masuda, Yamamoto
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    PCB and PCB metabolites in serum from Yusho patients 37 years after the accident2008Inngår i: Svensk-norsk miljökjemisk vintermöte: SNMM 2008, 22-24 September, 2008Konferansepaper (Annet (populærvitenskap, debatt, mm))
  • 17.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Park, June-Soo
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Hertz-Picciotto, Irva
    Analys av PCB metaboliter i gravida kvinnor och i navelsträngsblod från Slovakien2007Inngår i: Svensk-norsk miljökjemisk vintermöte: Dr. Holms Hotell, Geilo, Norge, 2007, s. 28-Konferansepaper (Annet vitenskapelig)
  • 18.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Park, June-Soo
    Kocan, Anton
    Trnovec, Tomas
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Hertz-Picciotto, Irva
    Maternal and cord serum exposure to PCB and DDE methyl sulfone metabolites in eastern Slovakia2007Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 69, nr 3, s. 403-410Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Polychlorinated biphenyls (PCBs) were commercially produced between 1959 and 1984 in eastern Slovakia. Improper handling led to a highly contaminated local environment and high levels of PCBs in humans and wildlife in the Michalovce area. The aim of this study was to analyse serum for methylsulfonyl metabolites of PCB (MeSO2-PCBs) and DDE (3-MeSO2-DDE) in serum samples from pregnant women and in a selected number of paired cord blood samples to assess maternal sulfone levels and patterns, and transplacental transfer of these metabolites. The donating women were from two districts in eastern Slovakia. A liquid–liquid extraction method together with separation of substance groups and further clean-up on silica gel columns were applied prior to analysis by gas chromatography/mass spectrometry. 3-MeSO2-DDE was the major methyl sulfone in most of the samples followed by a yet not identified MeSO2-hexaCB, 4′-MeSO2-CB101, 4′-MeSO2-CB87 and 4-MeSO2-CB149. The women from the contaminated area had three times higher concentrations of the MeSO2-PCBs than women from the reference area. This is the first report on methyl sulfone metabolites of PCB and DDE in human cord serum. It is shown that these metabolites are transported through the placenta. The levels of MeSO2-PCBs in the maternal serum were about 1.5 times higher than in the corresponding cord serum on a lipid weight basis. For 3-MeSO2-DDE, the levels were about the same in maternal and cord serum. The difference in the maternal:cord ratio, comparing MeSO2-PCBs with 3-MeSO2-DDE might be due to differences in transport through the placenta caused by their different affinities for lipoproteins and plasma proteins.

  • 19. Mamun, M. I. R.
    et al.
    Zamir, Rausan
    Nilufar, Nahar
    Mosihuzzaman, M
    Linderholm, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Traditional organochlorine pollutants in blood from humans living in the Bangladesh capital area2007Inngår i: Organohalogen Compounds: Human exposure I (Level and trends), 2007, s. 2026-2030Konferansepaper (Fagfellevurdert)
  • 20. Park, June-Soo
    et al.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Linderholm, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Kocan, Anton
    Petrik, Jan
    Drobna, Beata
    Trnovec, Tomas
    Charles, M Judith
    Hertz-Picciotto, Irva
    Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia.2008Inngår i: Chemosphere, ISSN 0045-6535, Vol. 70, nr 9, s. 1676-84Artikkel i tidsskrift (Fagfellevurdert)
  • 21. Qiu, Yanling
    et al.
    Strid, Anna
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bignert, Anders
    Zhu, Zhiliang
    Zhao, Jianfu
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanassiadis, Loannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Chlorinated and brominated organic contaminants in fish from Shanghai markets: A case study of human exposure2012Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 89, nr 4, s. 458-466Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the present study were two favorite edible fish species for local residents, i.e., mandarin fish and crawfish, collected from the Shanghai market and analyzed for selected organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), hexabromocyclododecane (HBCDD), polybrominated diphenyl ethers (PBDEs) and methoxylated PBDEs (MeO-PBDEs). Efforts were also made to identify the potential sources of these contaminants. Comparable concentrations of hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs) and HBCDD were found in muscle tissue of mandarin fish from Guangdong (GDF), the Pearl River Delta and from Taihu Lake (TLF), the Yangtze River Delta. Levels of chlordanes, PCBs and PBDEs were about one magnitude lower in TLF compared to GDF. The concentrations of OCPs in the butter-like gland of the crawfish (CFB) were 2-5 times of those in the crawfish muscle (CFM) while concentrations of PCBs, PBDEs and MeO-PBDEs were comparable. The different patterns and levels of chlorinated and brominated organo-halogen contaminants seen in mandarin fish from GDF and TLF indicates that different types of chemicals might be used in the two delta regions. The present study also shows a good correlation between the concentrations of hexachlorobenzene (HCB) and pentachloroanisol (PCA) in fish for the first time. Fish consumption limits based on chemical contaminants with non-carcinogenic effects were calculated. The estimated maximum daily consumption limit for GDF,TLF, CFM and CFB were 1.5, 2.6, 3.7 and 0.08 kg, respectively, indicating no significant risk regarding the persistent organic pollutants measured in the present study.

  • 22.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Svavarsson, Jörundur
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Brominated organic compounds in a high trophic Arctic fish species, Greenland shark (Somniosus microcephalus)2008Inngår i: 6:e Svensk-norskt miljökemiskt möte: SNMM 2008 22-24 September, 2008Konferansepaper (Annet (populærvitenskap, debatt, mm))
  • 23.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Svavarsson, Jörundur
    Bergman, Åke
    Brominated organic compounds in a high trophic arctic fish species, Greenland shark (Somniosus microcephalus)2008Inngår i: Organohalogen Compounds: pops in marine mammals: Levels, effects, trends, 2008, s. 817-820Konferansepaper (Fagfellevurdert)
  • 24.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Svavarsson, Jörundur
    University of Iceland, Institute of Biology.
    Päpke, Olaf
    Eurofins GfA, Hamburg.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Neutral and phenolic brominated organic compounds of natural and anthropogenic origin in Northeast Atlantic Greenland shark (Somniosus microcephalus)2010Inngår i: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 29, nr 12, s. 2653-2659Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the present study, muscle and liver tissue from 10 female Greenland sharks (Somniosus microcephalus) collected in Icelandic waters were analyzed for neutral and phenolic brominated organic compounds, including polybrominated diphenyl ethers (PBDEs) and the structurally related methoxylated (MeO) and hydroxylated (OH) PBDEs. Hydroxylated PBDEs exist both as natural products and as metabolites of the anthropogenic PBDEs, whereas MeO-PBDEs appear to exclusively be of natural origin. Other compounds examined were 2′,6-dimethoxy-2,3′,4,5′-tetrabromodiphenyl ether (2′,6-diMeO-BDE68), 2,2′-dimethoxy-3,3′,5,5′-tetrabromobiphenyl (2,2′-diMeO-BB80), 2,4,6-tribromoanisol (2,4,6-TBA) and 2,4,6-tribromophenol, all of natural origin, although 2,4,6-TBA and its phenolic counterpart may also be of anthropogenic origin. The major brominated organic compound was 6-MeO-BDE47, and ΣMeO-PBDE ranged from 49 to 210 ng/g fat in muscle and from 55 to 200 ng/g fat in liver tissue. Total concentrations of PBDEs were lower than ΣMeO-PBDE, in all but one sample, ranging between 7.3 to 190 and 9.9 to 200 ng/g fat in muscle and liver, respectively, and major congeners were BDE-47, BDE-99, and BDE-100. Polybrominated diphenyl ethers were analyzed using both high- and low-resolution mass spectrometry (MS) as a quality assurance, and the results from this comparison were acceptable. In accordance with previous work on Greenland sharks, no size/age-related accumulation was observed. Differences seen in concentrations were instead assumed to be a reflection of different feeding habits among the individuals. Phenolic compounds were only formed/retained in trace amounts in the Greenland shark. Among the phenolic compounds studied were 6-OH-BDE47, 2′-OH-BDE68, and 2,4,6-tribromophenol, all detected in liver and the latter two in muscle

  • 25. Zamir, R
    et al.
    Athanasiadou, M
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Nahar, N
    Mamun, M I R
    Mosihuzzaman, M
    Bergman, Å
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Persistent organohalogen contaminants in plasma from groups of humans with different occupations in Bangladesh2009Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 74, nr 3, s. 453-459Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The present study is aimed to assess persistent organic halogenated pollutants in humans living in Bangladesh. The results are compared to other similar studies in the region and globally. Human blood plasma were collected from groups of men and women with different occupations, i.e. being students, garment industry workers, employees at the Power Development Board (PDB), all groups in Dhaka, fishermen and fishermen wife's from Dhaka and another group from Barisal district. The plasma was analysed for hexachlorobenzene (HCB), the hexachlorocyclohexane isomers, alpha-HCH, beta-HCH, gamma-HCH and delta-HCH, the DDT group of chemicals, chlordane compounds, trans-chlordane, cis-chlordane, oxychlordane, trans-nonachlor, trans-heptachlorepoxide, methoxychlor and mirex. The most abundant contaminant, in all groups studied, p,p'-DDE is dominating, with p,p'-DDT/ summation operatorDDT ratios indicating recent and ongoing DDT exposure. Among the other pesticides analysed beta-HCH is the most abundant indicating the use of technical HCH products instead of Lindane (gamma-HCH). While the summation operatorDDT is present in the low ppm range the beta-HCH is detected in up to approx. 400ppb, lipid basis. The beta-HCH is most abundant in the groups of students. In contrast to the pesticides analysed very low concentrations of polychlorinated biphenyls (PCB) are present in all study groups, with e.g. CB-153 in the range of 5-30ngg(-1) fat. The concentrations of the DDT group of chemical differ significantly between fishermen and fishermen's wives living and working in the Dhaka area versus those living and working in Barisal. Also, fishermen and their wives had significantly different concentrations of DDT compared to garment industry workers.

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