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  • 1. Atoufi, Zhaleh
    et al.
    Kamrava, Seyed Kamran
    Davachi, Seyed Mohammad
    Hassanabadi, Majid
    Saeedi Garakani, Sadaf
    University of Medical Sciences (IUMS), Iran; University of Tehran, Iran.
    Alizadeh, Rafieh
    Farhadi, Mohammad
    Tavakol, Shima
    Bagher, Zohreh
    Hashemi Motlagh, Ghodratollah
    Injectable PNIPAM/Hyaluronic acid hydrogels containing multipurpose modified particles for cartilage tissue engineering: Synthesis, characterization, drug release and cell culture study2019Ingår i: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 139, s. 1168-1181Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Novel injectable thermosensitive PNIPAM/hyaluronic acid hydrogels containing various amounts of chitosan-g-acrylic acid coated PLGA (ACH-PLGA) micro/nanoparticles were synthesized and designed to facilitate the regeneration of cartilage tissue. The ACH-PLGA particles were used in the hydrogels to play a triple role: first, the allyl groups on the chitosan-g-acrylic acid shell act as crosslinkers for PNIPAM and improved the mechanical properties of the hydrogel to mimic the natural cartilage tissue. Second, PLGA core acts as a carrier for the controlled release of chondrogenic small molecule melatonin. Third, they could reduce the syneresis of the thermosensitive hydrogel during gelation. The optimum hydrogel with the minimum syneresis and the maximum compression modulus was chosen for further evaluations. This hydrogel showed a great integration with the natural cartilage during the adhesion test, and also, presented an interconnected porous structure in scanning electron microscopy images. Eventually, to evaluate the cytotoxicity, mesenchymal stem cells were encapsulated inside the hydrogel. MTT and Live/Dead assay showed that the hydrogel improved the cells growth and proliferation as compared to the tissue culture polystyrene. Histological study of glycosaminoglycan (GAG) showed that melatonin treatment has the ability to increase the GAG synthesis. Overall, due to the improved mechanical properties, low syneresis, the ability of sustained drug release and also high bioactivity, this injectable hydrogel is a promising material system for cartilage tissue engineering.

  • 2.
    Khodadadi Yazdi, Mohsen
    et al.
    University of Tehran, Iran.
    Hashemi Motlagh, Ghodratolah
    University of Tehran, Iran.
    Saeedi Garakani, Sadaf
    University of Tehran, Iran.
    Boroomand, Ali
    University of Tehran, Iran.
    Effects of multiwall carbon nanotubes on the polymerization model of aniline2018Ingår i: Journal of polymer research, ISSN 1022-9760, E-ISSN 1572-8935, Vol. 25, artikel-id 265Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this paper, chemical polymerization of aniline and aniline/multi-walled carbon nanotubes (MWCNTs) is investigated, and a modified polymerization model is proposed based on the obtained experimental results. In the experimental section, the variation in temperature of the reaction mixture was measured during the polymerization reaction. According to the obtained thermographs, it was concluded that the polymerization of aniline or aniline/MWCNTs takes place in three different steps. In the first step, some nuclei of phenazine-type trimers are formed for pure aniline while for aniline/MWCNTs, aniline molecules are adsorbed on the nanotubes surfaces. In the second step, cation-radical polymerization occurs at a high speed where there are a significant number of monomers around the growing chains. It is proposed that in the third step a new polymerization reaction begins on the pre-synthesized polymers. For pure PANI, it seems that only oligomers are created in this step while for PANI/MWCNTs, long chain polymers can also grow. Experimental results show that the enthalpy of polymerization reduces while polymerization yield increases with the weight percent of MWCNTs, which can be explained by the new observed polymerization model.

  • 3. Mousavi Nejad, Zohre
    et al.
    Torabinejad, Bahman
    Davachi, Seyed Mohammad
    Zamanian, Ali
    Saeedi Garakani, Sadaf
    University of Tehran, Iran.
    Najafi, Farhood
    Nezafati, Nader
    Synthesis, physicochemical, rheological and in-vitro characterization of double-crosslinked hyaluronic acid hydrogels containing dexamethasone and PLGA/dexamethasone nanoparticles as hybrid systems for specific medical applications2019Ingår i: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 126, s. 193-208Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Injectable hydrogels and biodegradable nanoparticles are using in tissue engineering applications and drug delivery systems. To improve physiochemical properties of biomaterials and to develop their applications, hybrid systems consist of hydrogels, and biodegradable nanoparticles were synthesized. In this study, hybrid systems based on double crosslinked hyaluronic acid and PLGA/Dexamethasone sodium phosphate (PLGADEX) nanoparticles are designed and synthesized in several steps. At the first step, poly(l-lactide-co-glycolide) (PLGA) in a ratio of LLA:GA = 85:15 mol% was synthesized via ring-opening polymerization. Then, PLGADEX nanoparticles were synthesized in different ratios using the partially modified emulsification-diffusion method and fully characterized, and desirable nanoparticle was selected (PLGADEX20). At the second step, a double cross-linked hyaluronic acid (XHA) was prepared by mixing various ratios of amino-hyaluronic acid and aldehyde-hyaluronic acid in the presence of genipin. Finally, by mixing of various ratios of PLGADEX20 and Dexamethasone sodium phosphate (DEX) with different ratios of XHA, hybrid systems were prepared. Based on the characterization of hybrid samples and the release studies, hydrogels containing nanoparticles showed a controlled drug release, while the best sample with 3% of optimized nanoparticle was chosen. According to physiochemical and biological properties, these hybrid systems can be good candidates for anti-adhesion barriers, wound dressings, and novel drug delivery systems.

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