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  • 101.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Masuda, Y
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    PCB and PCB metabolites in serum from Yusho patients 37 years after the accident2007Ingår i: Organohalogen Compounds: Yusho and Yucheng-clinical and epidimiological aspect, 2007, s. 2141-2144Konferensbidrag (Refereegranskat)
  • 102.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Masuda, Yamamoto
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    PCB and PCB metabolites in serum from Yusho patients 37 years after the accident2008Ingår i: Svensk-norsk miljökjemisk vintermöte: SNMM 2008, 22-24 September, 2008Konferensbidrag (Övrig (populärvetenskap, debatt, mm))
  • 103.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Park, June-Soo
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Hertz-Picciotto, Irva
    Analys av PCB metaboliter i gravida kvinnor och i navelsträngsblod från Slovakien2007Ingår i: Svensk-norsk miljökjemisk vintermöte: Dr. Holms Hotell, Geilo, Norge, 2007, s. 28-Konferensbidrag (Övrigt vetenskapligt)
  • 104.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Park, June-Soo
    Hovander, Lotta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Kocan, Anton
    Trnovec, T
    Hertz-Picciotto, Irva
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Human exposure to PCB metabolites in a hot-spot area in eastern slovakia2007Ingår i: Organohalogen Compounds: Human exposure II (Environmental exposure), 2007, s. 750-753Konferensbidrag (Refereegranskat)
  • 105.
    Linderholm, Linda
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Park, June-Soo
    Kocan, Anton
    Trnovec, Tomas
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Hertz-Picciotto, Irva
    Maternal and cord serum exposure to PCB and DDE methyl sulfone metabolites in eastern Slovakia2007Ingår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 69, nr 3, s. 403-410Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Polychlorinated biphenyls (PCBs) were commercially produced between 1959 and 1984 in eastern Slovakia. Improper handling led to a highly contaminated local environment and high levels of PCBs in humans and wildlife in the Michalovce area. The aim of this study was to analyse serum for methylsulfonyl metabolites of PCB (MeSO2-PCBs) and DDE (3-MeSO2-DDE) in serum samples from pregnant women and in a selected number of paired cord blood samples to assess maternal sulfone levels and patterns, and transplacental transfer of these metabolites. The donating women were from two districts in eastern Slovakia. A liquid–liquid extraction method together with separation of substance groups and further clean-up on silica gel columns were applied prior to analysis by gas chromatography/mass spectrometry. 3-MeSO2-DDE was the major methyl sulfone in most of the samples followed by a yet not identified MeSO2-hexaCB, 4′-MeSO2-CB101, 4′-MeSO2-CB87 and 4-MeSO2-CB149. The women from the contaminated area had three times higher concentrations of the MeSO2-PCBs than women from the reference area. This is the first report on methyl sulfone metabolites of PCB and DDE in human cord serum. It is shown that these metabolites are transported through the placenta. The levels of MeSO2-PCBs in the maternal serum were about 1.5 times higher than in the corresponding cord serum on a lipid weight basis. For 3-MeSO2-DDE, the levels were about the same in maternal and cord serum. The difference in the maternal:cord ratio, comparing MeSO2-PCBs with 3-MeSO2-DDE might be due to differences in transport through the placenta caused by their different affinities for lipoproteins and plasma proteins.

  • 106. Lunder, Sonya
    et al.
    Hovander, Lotta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Significantly Higher Polybrominated Diphenyl Ether Levels in Young US Children than in Their Mothers2010Ingår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 44, nr 13, s. 5256-5262Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    While young children are rarely included in biomonitoring studies, they are presumed to be at greater risk of ingesting environmental contaminants—particularly those that accumulate in foods or shed from consumer products. The widely used fire retardants polybrominated diphenyl ethers (PBDEs) are ubiquitous contaminants in the indoor environment and are widely detected at higher levels in Americans than in individuals from other countries. However, there are only three studies of PBDEs in U.S. children. We hypothesized that PBDEs are present in higher concentrations in young children than their mothers. PBDEs were assessed in blood samples collected concurrently from 20 mothers and their children, ages 1.5 to 4 years. The chemical analyses were performed by GC/MS applying selected ion monitoring. The samples were analyzed for 20 PBDE congeners; 11 were detected. ΣPBDEs for children were typically 2.8 times higher than for mothers, with median child:mother ratios varying from 2 to 4 for individual congeners. In 19 of 20 families studied, children had higher ΣPBDE concentrations than their mothers with significant (p < 0.01) concentration differences for five of the PBDE congeners. Decabromodiphenyl ether (BDE-209) was quantitated in 13 children and 9 mothers. Other studies indicate PBDEs are not elevated at birth, suggesting that early life is an intense period of PBDE intake. Children’s increased hand-to-mouth activity, dietary preferences, and exposures from breast milk may result in greater ingestion of PBDEs than adults. These findings suggest that measurements from adults likely do not reflect exposures to young children despite sharing homes and similar diets. 

  • 107. Lunder, Sonya
    et al.
    Hovander, Lotta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Polybrominated diphenyl ethers in serum from Californian mother – child pairs2009Ingår i: Organohalogen Compounds, Vol. 71, Peking, 2009, s. 2726-2730Konferensbidrag (Refereegranskat)
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  • 108. Lyche, Jan L.
    et al.
    Gutleb,, Arno C
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Eriksen,, Gunnar S
    Murk, AlberTinka J
    Ropstad, Erik Saunders
    Margaret, Skaare, Janneche U
    Reproductive and developmental toxicity of phthalates2009Ingår i: Journal of toxicology and environmental health. Part B, Critical reviews, ISSN 1093-7404, E-ISSN 1521-6950, Vol. 12, nr 4, s. 225-249Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The purposes of this review are to (1) evaluate human and experimental evidence for adverse effects on reproduction and development in humans, produced by exposure to phthalates, and (2) identify knowledge gaps as for future studies. The widespread use of phthalates in consumer products leads to ubiquitous and constant exposure of humans to these chemicals. Phthalates were postulated to produce endocrine-disrupting effects in rodents, where fetal exposure to these compounds was found to induce developmental and reproductive toxicity. The adverse effects observed in rodent models raised concerns as to whether exposure to phthalates represents a potential health risk to humans. At present, di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DBP), and butyl benzyl phthalate (BBP) have been demonstrated to produce reproductive and developmental toxicity; thus, this review focuses on these chemicals. For the general population, DEHP exposure is predominantly via food. The average concentrations of phthalates are highest in children and decrease with age. At present, DEHP exposures in the general population appear to be close to the tolerable daily intake (TDI), suggesting that at least some individuals exceed the TDI. In addition, specific high-risk groups exist with internal levels that are several orders of magnitude above average. Urinary metabolites used as biomarkers for the internal levels provide additional means to determine more specifically phthalate exposure levels in both general and high-risk populations. However, exposure data are not consistent and there are indications that secondary metabolites may be more accurate indicators of the internal exposure compared to primary metabolites. The present human toxicity data are not sufficient for evaluating the occurrence of reproductive effects following phthalate exposure in humans, based on existing relevant animal data. This is especially the case for data on female reproductive toxicity, which are scarce. Therefore, future research needs to focus on developmental and reproductive endpoints in humans. It should be noted that phthalates occur in mixtures but most toxicological information is based on single compounds. Thus, it is concluded that it is important to improve the knowledge of toxic interactions among the different chemicals and to develop measures for combined exposure to various groups of phthalates.

  • 109.
    Löfstrand, K
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Malmvärn, A
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Asplund, L
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Trends and exposure of OH-PBDEs, MeO-PBDEs and PBDEs in baltic BIOTA2010Ingår i: Organohalogen Compounds, 2010Konferensbidrag (Övrigt vetenskapligt)
  • 110.
    Löfstrand, Karin
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Asplund, Lillemor
    High concentrations of 6-hydroxylated - 2,2´,4,4´-tetrabromodiphenyl ether in herring (Clupea harengus) plasma from the Baltic Sea2008Ingår i: Svensk Norsk miljömöte 2008: SNMM 2008, 2008Konferensbidrag (Övrig (populärvetenskap, debatt, mm))
  • 111.
    Löfstrand, Karin
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Haglund, Peter
    Umeå universitet, Kemiska institutionen.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Kautsky, Lena
    Stockholms universitet, Naturvetenskapliga fakulteten, Botaniska institutionen.
    Asplund, Lillemor
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Hydroxylated and methoxylated polybrominated diphenyl ethers and polybrominated dibenzo-p-dioxins in algae and blue mussels from the Swedish coast line - patterns and correlationsManuskript (preprint) (Övrigt vetenskapligt)
  • 112.
    Löfstrand, Karin
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Jörundsdóttir, Hrönn
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Tomy, Gregg
    Svavarsson, Jörundur
    Weihe, Pál
    Nygård, Torgeir
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Spatial trends of polyfluorinated compounds in guillemot (Uria aalge) eggs from North-Western Europe2008Ingår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 72, nr 10, s. 1475-1480Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Polyfluorinated alkyl compounds (PFCs) are a group of chemicals of growing concern that have been detected in biological and abiotic samples worldwide. This study reports the concentrations of a suite of PFCs: perfluorooctyl sulfonate (PFOS), perfluorooctyl sulfonamide (PFOSA) and perfluorinated carboxylic acids (PFCAs) in guillemot (Uria aalge) eggs, collected in North-Western Europe, from Iceland, the Faroe Islands, Sweden and two locations in Norway. The highest concentrations of PFOS were found in samples from Sweden (mean 400 ng g(-1) wet weight (w.w.)), which were almost five times higher than concentrations found in Norwegian samples (mean 85 ng g(-1) w.w. from both sample sites). The concentrations found in Icelandic and Faroe samples were lowest (mean 16 and 15 ng g(-1) w.w., respectively). Only Swedish samples differed signiflcantly from the other locations. In general, PFCAs show a different spatial trend than PFOS. Perfluorooctanoic acid (PFOA) was not detected in any sample and perfluorononanoic acid (PFNA) was only detected in samples from Sweden. The most abundant PFCA was perfluoroundecanoic acid (PFUA) with highest concentrations in samples from Sweden (mean 82 ng g(-1) w.w.), samples from the Faroe Islands had the second highest concentration (mean 57 ng g(-1) w.w.) and samples from Iceland and Norway had concentrations ranging between 18 and 30 ng g(-1) w.w. The original hypothesis was based on the idea that PFC concentrations are the highest close to more densely populated and industrialized areas and lower levels in remote areas. However, the geographic pattern is more complicated than predicted and varies among different PFCs.

  • 113.
    Löfstrand, Karin
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Malmvärn, Anna
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Haglund, Peter
    Umeå Universitet, Kemiska institutionen.
    Bignert, Anders
    Naturhistoriska riksmuseet, Miljögiftsforskning.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Asplund, Lillemor
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Brominated phenols, anisoles, and dioxins present in blue mussels from the Swedish coastline2010Ingår i: Environmental Science and Pollution Research, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 17, nr 8, s. 1460-1468Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Introduction  

    Naturally occurring hydroxylated polybrominated diphenyl ethers (OH-PBDEs), their methoxylated counterparts (MeO-PBDEs), and polybrominated dibenzo-p-dioxins (PBDDs), together with their potential precursors polybrominated phenols (PBPs) and polybrominated anisoles (PBAs), were analyzed in blue mussels (Mytilus edulis) gathered along the east coast (bordering the Baltic Sea) and west coast of Sweden (bordering the North Sea). Brown algae (Dictyosiphon foenicolaceus) and cyanobacteria (Nodularia spumigena) from the Baltic Sea, considered to be among the primary producers of these compounds, were also analyzed for comparison.

    Materials and methods  

    The samples were liquid–liquid extracted, separated into a phenolic and a neutral fraction, and subsequently analyzed by gas chromatography–mass spectrometry (GS-MS).

    Results and discussion  

    The levels of OH-PBDEs, MeO-PBDEs and PBDDs were significantly higher in Baltic Sea mussels than in those from the west coast, whereas the levels of PBPs and PBAs displayed the opposite pattern. The blue mussels from the Baltic Sea contained high levels of all analyzed substances, much higher than the levels of, e.g., polybrominated diphenyl ethers. In addition, the GC-MS chromatogram of the phenolic fraction of the west coast samples was dominated by four unknown peak clusters, three of which were tentatively identified as dihydroxy-PBDEs and the other as a hydroxylated-methyl-tetraBDE.

    Conclusions  

    Clearly, all of the compounds analyzed are natural products, both in the Baltic and the North Sea. However, the geographical differences in composition may indicate different origin, e.g., due to differences in the occurrence and/or abundance of various algae species along these two coasts or possibly a more extensive dilution on the west coast.

  • 114.
    MacInnis, Gordia
    et al.
    Environment Canada, Burlington, Canada.
    Letcher, Robert
    Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Canada.
    McKinney, Melissa
    Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Canada.
    Tomy, Gregg T.
    Fisheries & Oceans Canada, Winnipeg, Canada.
    Fång, Johan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Marvin, Chris H.
    Environment Canada, Burlington, Canada.
    In vitro bioassay of racemic α- and γ-HBCD using liver microsomes from top trophic level Arctic marine mammals: enantiomeric-specific depletion and formation of hydroxylated HBCD metabolites2010Ingår i:  , 2010Konferensbidrag (Övrigt vetenskapligt)
  • 115. MacInnis, Gordia
    et al.
    Letcher, Robert
    McKinney, Melissa
    Tomy, Gregg T.
    Lebeuf, M.
    Fång, Johan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Marvin, Chris H.
    Investigation of HBCD metabolism in marine mammals from Canada using a hapatic micrsomal in vitro bioassay approach and comparison with field samples2010Konferensbidrag (Övrigt vetenskapligt)
  • 116. Malkiewicz, Katarzyna
    et al.
    Andersson, Patrik
    Nordberg, Anna
    Bergman,, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Hansson, Sven Ove
    Ruden, Christina
    Human experts' judgment of chemicals reactivity for identification of hazardous chemicals2009Ingår i: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 189, s. S243-S243Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    The development of non-testing approaches for the identification

    of chemicals with the potential to cause environmental hazards,

    have gained increased attention. In this study the hypothesis that

    experts’ judgement of chemical reactivity could be used for this

    purpose has been tested. The judgments of chemical reactivity for

    200 organic chemicals, based on their molecular structure were

    performed by four senior organic and environmental chemists.

    Potentials for reactivity (namely: oxidative/reductive reactivity,

    hydrolysis, direct photolysis, reactivity towards radicals) were

    scored on the 1– scale. Both the experts’ individual judgment,

    and a compromised judgment after joint discussion for clarification

    of cases with divergent opinions, was analysed. Furthermore we

    searched for relations between the expert judgement data and: (a)

    the chemical characteristics representedby 40 chemical descriptors

    using partial least squares regression (PLS), and (b) experimental

    and in silico data for different toxicological and physico-chemical

    end-points. The results of on-going analyses indicate that for the

    majority of the chemicals, the individual judgments differed significantly

    between experts but after discussion among the experts

    for clarification, the judgments becamemuch more concurrent. The

    relation between averaged experts’ predicted photolytic degradation

    potential and chemical characteristic based on a PLS model

    (with three significant components explaining 76% of the variation)

    was found. We have also found that in the group of the

    chemicals with the higher score of the experts judged oxidative

    reactivity there was higher percentage of biodegradable chemicals

    when compar

  • 117.
    Malmvärn, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Zebühr, Yngve
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för tillämpad miljövetenskap (ITM).
    Kautsky, Lena
    Stockholms universitet, Naturvetenskapliga fakulteten, Botaniska institutionen.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Asplund, Lillemor
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för tillämpad miljövetenskap (ITM).
    Hydroxylated and methoxylated polybrominated diphenyl ethers and polybrominated dibenzo-p-dioxins in red alga and cyanobacteria living in the Baltic Sea2008Ingår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 72, nr 6, s. 910-916Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) and methoxylated polybrominated diphenyl ethers (MeO-PBDEs) are present in the ecosystem of the Baltic Sea. OH-PBDEs are known to be both natural products from marine environments and metabolites of the anthropogenic polybrominated diphenyl ethers (PBDEs), whereas, MeO-PBDEs appear to be solely natural in origin. Polybrominated dibenzo-p-dioxins (PBDDs) are by-products formed in connection with the combustion of brominated flame retardants (BFRs), but are also indicated as natural products in a red alga (Ceramium tenuicorne) and blue mussels living in the Baltic Sea. The aims of the present investigation were to quantify the OH-PBDEs and MeO-PBDEs present in C. tenuicorne; to verify the identities of PBDDs detected previously in this species of red alga and to investigate whether cyanobacteria living in this same region of the Baltic Sea contain OH-PBDEs, MeO-PBDEs and/or PBDDs. The red alga was confirmed to contain tribromodibenzo-p-dioxins (triBDDs), by accurate mass determination and additional PBDD congeners were also detected in this sample. This is the first time that PBDDs have been identified in a red alga. The SigmaOH-PBDEs and SigmaMeO-PBDEs concentrations, present in C. tenuicorne were 150 and 4.6ngg(-1) dry weight, respectively. In the cyanobacteria 6 OH-PBDEs, 6 MeO-PBDEs and 4 PBDDs were detected by mass spectrometry (electron capture negative ionization (ECNI)). The PBDDs and OH-PBDEs and MeO-PBDEs detected in the red alga and cyanobacteria are most likely of natural origin.

  • 118. Mamun, M. I. R.
    et al.
    Zamir, Rausan
    Nilufar, Nahar
    Mosihuzzaman, M
    Linderholm, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Traditional organochlorine pollutants in blood from humans living in the Bangladesh capital area2007Ingår i: Organohalogen Compounds: Human exposure I (Level and trends), 2007, s. 2026-2030Konferensbidrag (Refereegranskat)
  • 119. Meijer, Lisethe
    et al.
    Brouwer, Baram
    de Jong, Frank H.J.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Sauer, Pieter J.J.
    Influence of prenatal exposure to selected organohalogans on infant sexual and neurological development2008Konferensbidrag (Refereegranskat)
  • 120. Meijer, Lisethe
    et al.
    Weiss, Jana
    Van Velzen, Martin
    Brouwer, Abraham
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Sauer, Pieter J J
    Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands.2008Ingår i: Environ Sci Technol, ISSN 0013-936X, Vol. 42, nr 9, s. 3428-33Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    As part of a large European Union (EU)-funded comparative toxicology and human epidemiology study, EU-Compare, a selection of organohalogen compounds (OHCs) was analyzed in maternal serum, collected at the 35th week of pregnancy, and in cord serum of a number of their infants to determine maternal concentrations and to investigate the extent of transplacental transfer of these compounds. Eight neutral OHCs were analyzed: one polychlorinated biphenyl (PCB: CB-153),4,4'-DDE, five polybrominated diphenyl ethers (PBDEs: BDE-47, BDE-99, BDE-100, BDE-153, and BDE-154), and hexabromocyclododecane (HBCDD). Five phenolic OHCs were analyzed: three hydroxylated PCBs (40H-CB-107, 40H-CB-146, and 40H-CB-187), one hydroxylated PBDE (60H-BDE-47), and pentachlorophenol (PCP). All OHCs, except 60H-BDE-47, were present in maternal and cord serum. The historically identified OHCs showed the highest concentration: 4,4'-DDE (median value 89 ng/g lipid in maternal serum and 68 ng/g lipid in cord serum) and PCP (median value 970 pg/g serum in maternal serum and 1500 pg/g serum in cord serum). HBCDD and the PBDEs were present at much lower concentrations. We conclude that OHCs are present in the serum of pregnant women, and all compounds tested are transferred over the placenta. Because transfer is occurring at a critical stage of infant development, investigation of the health impact is urgent.

  • 121. Montano, Mauricio
    et al.
    Cocco, Emmanuelle
    Guignard, Cedric
    Marsh, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Hoffmann, Lucien
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Gutleb, Arno Christian
    Murk, Albertinka Jacoba
    New Approaches to Assess the Transthyretin Binding Capacity of Bioactivated Thyroid Hormone Disruptors2012Ingår i: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 130, nr 1, s. 94-105Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Polychlorinated biphenyls (PCBs) and polybrominated diphenyl-ethers (PBDEs) are metabolized into hydroxylated metabolites (OH-PCBs/PBDEs), which can disrupt the thyroid hormone homeostasis. Binding of these metabolites to transport proteins such as transthyretin (TTR) is an important mechanism of their toxicity. Several methods to quantify the competitive thyroxine (T-4) displacement potency of pure metabolites exist. However, quantification of the potency of in vitro metabolized PCBs and PBDEs has drawbacks related to the coextraction of compounds disturbing the T-4-TTR competitive binding assay. This study identifies and quantifies the major coextractants namely cholesterol, saturated and nonsaturated fatty acids (SFA and NSFA) at levels above 20 nmol per mg equivalent protein following various extraction methods. Their TTR binding potency was analyzed in a downscaled, nonradioactive fluorescence displacement assay. At concentration factors needed for TTR competitive binding, at least 10M of these coextracts is present, whereas individual SFA and NSFA disturb the assay from 0.3M. The effectiveness of the in vitro metabolism and extraction of the model compounds CB 77 and BDE 47 was chemically quantified with a newly developed chromatographic method analyzing silylated derivatives of the OH-metabolites and coextractants. A new method to selectively extract metabolites and limit coextraction of disturbing compounds to less than 5 nmol per mg equivalent protein is presented. It is now possible to make a dose-response curve up to 50% inhibition with bioactivated CB 77 and BDE 47. The toxic potencies of bioactivated persistent organic pollutants (POPs) should be taken into account to prevent serious underestimation of their hazard and risk.

  • 122.
    Moreira Bastos, Patricia
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Eriksson, Johan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Vidarson, Jenny
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Oxidative transformation of polybrominated diphenyl ether congeners (PBDEs) and of hydroxylated PBDEs (OH-PBDEs)2008Ingår i: Environmental Science and Pollution Research, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 15, nr 7, s. 606-613Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND, AIM, AND SCOPE: The historical and widespread use of polybrominated diphenyl ethers (PBDEs) as flame retardants in consumer products worldwide has caused PBDEs to now be regarded as pervasive environmental contaminants. Most recently, hydroxylated PBDEs (OH-PBDEs) and methoxylated PBDEs (MeO-PBDEs) have emerged as environmentally relevant due to reports of their natural production and metabolism. An important parameter for assessing the environmental impact of a chemical substance is persistence. By formulating the concept that persistence is the result of the substance's physicochemical properties and chemical reactivity, Green and Bergman have proposed a new methodology to determine the inherent persistence of a chemical. If persistence could be predicted by straightforward methods, substances with this quality could be screened out before large-scale production/manufacturing begins. To provide data to implement this concept, we have developed new methodologies to study chemical transformations through photolysis; hydrolysis, substitution, and elimination; and via oxidation. This study has focused on adapting an oxidative reaction method to be applicable to non-water soluble organic pollutants. MATERIALS AND METHODS: PBDEs and one MeO-PBDE were dissolved in tetrahydrofuran/methanol and then diluted in alkaline water. The OH-PBDEs were dissolved in alkaline water prior to reaction. The oxidation degradation reaction was performed at 50 degrees C using potassium permanganate as described elsewhere. The pH was maintained at 7.6 with disodium hydrogen phosphate and barium hydrogen phosphate, the latter also serving as a trapping agent for manganate ions. The oxidation reactions were monitored by high-performance liquid chromatography and reaction rates were calculated. RESULTS: The OH-PBDEs have very fast oxidative transformation rates compared to the PBDEs. The reaction rates seem to be primarily dependent on substitution pattern of the pi-electron-donating bromine substituents and of bromine content. There are indications that further reactions of OH-PBDEs, e.g., methylation to the MeO-PBDEs, decrease the oxidation rates, and thereby generate more persistent substances. DISCUSSION: The resistance of PBDEs to oxidation, a major degradation pathway in air, should be further investigated, since these compounds do undergo long range transport. With slight modifications, the original method has been adapted to include a larger variety of chemical substances, and preliminary data are now available on the oxidative transformation rates for PBDEs and of OH-PBDEs. CONCLUSIONS: The original oxidation degradation method can now include non-water soluble compounds. This modification, using low concentrations of test chemicals, allows us to measure oxidative transformation rates, for some of the lower brominated DEs, data that can be used to assess their persistence in future model calculations. Oxidative transformation rates for PBDEs are slow compared to those for the OH-PBDEs. This suggests that OH-PBDEs, when released into the environment, undergo faster oxidative metabolism and excretion than the PBDEs. RECOMMENDATIONS AND PERSPECTIVES: To evaluate the modified method, more degradation reactions with non-water soluble compounds should be investigated. Recent studies show that OH-PBDEs are present in rats and in humans and, because of their activity as endocrine disruptors, determining their subsequent environmental fate is of importance. The resistance of PBDEs to oxidative degradation should be acknowledged as of possible future concern. Several other compound classes (such as polychlorinated biphenyls (PCBs), hydroxylated polychlorinated biphenyls (OH-PCBs), and pharmaceuticals) need to be subjected to this screening method to increase the database of transformation rates that can be used with this model.

  • 123. Niu, Dong
    et al.
    Qiu, Yanling
    Du, Xinyu
    Li, Li
    Zhou, Yihui
    Yin, Daqiang
    Lin, Zhifen
    Chen, Ling
    Zhu, Zhiliang
    Zhao, Jianfu
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi. Shanghai Institute of Pollution Control and Ecological Security, China; Örebro University, Sweden.
    Novel brominated flame retardants in house dust from Shanghai, China: levels, temporal variation, and human exposure2019Ingår i: Environmental Sciences Europe, ISSN 2190-4707, E-ISSN 2190-4715, Vol. 31, artikel-id 6Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Novel brominated flame retardants (NBFRs) have been increasingly used as alternatives to legacy BFRs (e.g., PBDEs and HBCDs) in consumer products, but are liable to emigrate and contaminate indoor dust. In this study, a total of 154 house dust samples including floor dust (FD) and elevated surface dust (ESD) were collected in the biggest metropolitan area (Shanghai) of East China in 2016. Limited information about temporal variation of NBFRs indoors is available, while the period of sampling is influential in human exposure estimates. Levels, temporal variation, and human exposure of seven target NBFRs such as decabromodiphenylethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EHTBB), and bis(2-ethylhexyl) tetrabromophthalate (BEHTEBP) were investigated in indoor house dust.

    Results: Concentrations of Sigma(7)NBFRs ranged from 19.11 to 3099ng/g with a geomean of 295.1ng/g in FD, and from 34.74 to 404.6ng/g with a geomean of 117.9ng/g in ESD. The geomeans of DBDPE were 219.6ng/g in FD and 76.89ng/g in ESD, accounting for 90.5% and 80.5% of Sigma(7)NBFRs. Levels of EHTBB, BTBPE, and DBDPE in FD exceeded significantly those in ESD. The temporal variation in Sigma(7)NBFRs in FD was ranked as summer>winter>autumn>spring. The daily exposure doses (DEDs) of Sigma(7)NBFRs via dust ingestion decreased as: infants>toddlers>children>teenagers>adults. Infants showed the highest DED in FD, 9.1ng/kg bw/day.

    Conclusions: DBDPE clearly dominated the NBFRs in both FD and ESD, but the concentrations of DBDPE in this study were generally moderate compared with the other international studies. Dust ingestion was the major pathway of human exposure to NBFRs indoors. About eightfold difference in exposure estimates between infants and adults showed that infants faced elevated exposure risks in FD. This study highlighted the necessity to estimate human exposure of NBFRs for different age groups using FD and ESD, respectively.

  • 124.
    Norrgran Engdahl, Jessica
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Bignert, A.
    Jones, B.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi. Swedish Toxicology Sciences Research Centre (Swetox), Sweden.
    Weiss, Jana M.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Cats' Internal Exposure to Selected Brominated Flame Retardants and Organochlorines Correlated to House Dust and Cat Food2017Ingår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 51, nr 5, s. 3012-3020Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Pet cats may be used as a biomarker for assessing exposures to organohalogen compounds (OHCs) adsorbed to household dust in home environments. This study explores two exposure routes of OHCs, ingestion of OHCs (i) via house dust and (ii) via cat food. House dust from 17 Swedish homes and serum from the participating families' pet cats were collected, and cat food was purchased matching the diet reported. Paired samples of cat serum, house dust, and cat food were analyzed for brominated flame retardants/natural products (polybrominated diphenyl ethers (PBDEs), decabromobiphenyl (BB-209), decabromodiphenyl ethane (DBDPE), 2,4,6-tribromophenol (2,4,6-TBP), OH-PBDEs) and organochlorines (polychlorinated biphenyls (PCBs), 1,1-bis(4,4'-dichlorodipheny1)-2,2,2-trichloroethane (4,4'-DDT), 1,1-bis(4,4'-dichlorodiphenyl)-2,2-dichloroethene (4,4'-DDE), hexachlorobenzene (HCB), pentachlorophenol (PCP)). Significant correlations were found between serum and dust samples from the living rooms for BDE-47 (p < 0.035), BDE-99 (p < 0.035), and BDE-153 (p < 0.039), from the adult's bedroom for BDE-99 < 0.019) and from all rooms for BDE-99 (p < 0.020) and BB-209 (p < 0.048). This is the first time a correlation between cat serum levels and household dust has been established, a finding that supports the hypothesis that dust is a significant exposure route for cats. Serum levels were also significantly correlated with concentrations found in cat food for 6-OH-BDE47 (p < 0.002), 2,4,6-TBP (p < 0.035), and BB-209 (p < 0.007). DBDPE was found in high concentrations in all dust (median 154 pmol/g) and food samples (median 0.7 pmol/ig lw) but was below detection in serum samples, suggesting low or no bioavailability for DBDPE in cats.

  • 125.
    Norrgran Engdahl, Jessica
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Jones, Bernt
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Bignert, Anders
    Weiss, Jana
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Cats’ internal exposure to selected BFRs and organochlorines correlated to house dust and cat foodManuskript (preprint) (Övrigt vetenskapligt)
  • 126.
    Norrgran, J
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Jones, Bernt
    Lindquist, N-G
    Polybrominated diphenyl ethers and their metabolites, a potential cause for the development of the endocrine disorder hyperthyroidism in cats2010Ingår i: Organohalogen Compounds, 2010Konferensbidrag (Övrigt vetenskapligt)
  • 127.
    Norrgran, Jessica
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Jones, Bernt
    Bignert, Anders
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi. Swedish Toxicology Sciences Research Center (Swetox), Sweden.
    Higher PBDE Serum Concentrations May Be Associated with Feline Hyperthyroidism in Swedish Cats2015Ingår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 49, nr 8, s. 5107-5114Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Serum from 82 individual cats was analyzed for decabromobiphenyl (BB-209), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and 2,4,6-TBP in order to study differences in body burden between healthy and sick cats diagnosed with Feline Hyperthyroidism (FH). Within the study group, 60 of these cats had a euthyroid (n = 23) or hyperthyroid (n = 37) status, all of which were used in the comparison. This study shows that hyperthyroid compared to euthyroid cats have higher serum concentrations for some of the investigated PBDEs (BDE-99, BDE-153, and BDE-183) and CB-153 on a fat weight basis. Further, it is intriguing, and beyond explanation, why the flame retardant BB-209 (discontinued in 2000) is present in all of the cat serum samples in concentrations similar to BDE-209. Median BDE-47/-99 ratios are 0.47 and 0.32 for healthy and euthyroid cats, respectively, which differs significantly from Swedes, where the ratio is 3.5. Another important finding is the occurrence of very low levels or the absence of hydroxylated PBDE metabolites in the cats. In addition, the major OH-PBDE, 6-OH-BDE47, is likely of natural origin, probably ingested via cat food. The statistics indicate an association between elevated PBDE concentrations in the cats and FH.

  • 128.
    Norrgran, Jessica
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Jones, Bernt
    Lindquist, Nils-Gunnar
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Decabromobiphenyl, Polybrominated Diphenyl Ethers, and Brominated Phenolic Compounds in Serum of Cats Diagnosed With the Endocrine Disease Feline Hyperthyroidism2012Ingår i: Archives of Environmental Contamination and Toxicology, ISSN 0090-4341, E-ISSN 1432-0703, Vol. 63, nr 1, s. 161-168Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The incidence of cats being diagnosed with feline hyperthyroidism (FH) has increased greatly since it was first described in 1979. The cause of FH has not been established. Hypothetically, there is a link between increasing FH and exposure to brominated flame retardants. Much greater polybrominated diphenyl ethers (PBDE) concentrations have been reported in cat serum compared with human serum, likely due to cat licking behaviour. This study aimed to extend the present identification of brominated compounds in cat serum, with a focus on hydroxylated metabolites of PBDE, to improve the understanding of feline metabolism of PBDEs. A pooled serum sample from 30 Swedish pet cats with FH was analysed, and brominated species were identified. The results showed exposure to the discontinued flame retardant decabromobiphenyl (BB-209) and technical penta- and octa-BDEs. Altogether 12 PBDE congeners were identified along with 2'-MeO-BDE68. Furthermore, 2,4-dibromophenol, 2,4,6-, 2,4,5- and 2,3,4-tribromophenol plus 2'-OH-BDE68, 6-OH-BDE47, 5-OH-BDE47, 4'-OH-BDE49 were identified. 2,4,6-tribromophenol and 6-OH-BDE47 were the most prominent species in cat serum. Considering that these are natural products, it can be concluded that metabolism of PBDEs to OH-PBDEs is not a major route of PBDE elimination in cats. It is notable that BB-209, 6-OH-BDE47, and 2,4,6-tribromophenol all suggested that endocrine-disrupting chemicals were present in high concentrations in cat serum.

  • 129. Park,, Hye-Youn
    et al.
    Park,, June-Soo
    Sovcikova, Eva
    Kocan, Anton
    Linderholm, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Trnovec, Tomas
    Hertz-Picciotto, Irva
    Exposure to Hydroxylated Polychlorinated Biphenyls (OH-PCBs) in the Prenatal Period and Subsequent Neurodevelopment in Eastern Slovakia2009Ingår i: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 117, nr 10, s. 1600-1606Artikel i tidskrift (Refereegranskat)
  • 130. Park, June-Soo
    et al.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Linderholm, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Kocan, Anton
    Petrik, Jan
    Drobna, Beata
    Trnovec, Tomas
    Charles, M Judith
    Hertz-Picciotto, Irva
    Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia.2008Ingår i: Chemosphere, ISSN 0045-6535, Vol. 70, nr 9, s. 1676-84Artikel i tidskrift (Refereegranskat)
  • 131. Qiu, Yanling
    et al.
    Eriksson, Johan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Granelli, Lisa
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    An improved method for assessing relative nucleophilic substitution reactivities of polychlorinated benzenes2009Ingår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 75, nr 1, s. 78-82Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An existing substitution reaction method was improved as part of a system to measure the persistency of selected chemicals in the environment by evaluating their chemical reactivity. Hexachlorobenzene (HCB), pentachlorobenzene, 1,2,4,5-tetrachlorobenzene and 1,2,4-trichlorobenzene were selected as model compounds. Sodium methoxide in methanol was used as a nucleophile and found to be stable for at least 35 days after preparation. The substitution reaction system was modified so that nitrogen protection was not necessary to avoid oxidation and hydrolysis effects, which led to improved results. The reactivity of polychlorinated benzenes (PCBz), which substituted chlorine for methoxide according to a second-order rate constant, increased as the number of chlorine atoms on the benzene ring increased. HCB was selected as a standard for the k2 calculations of the substitution reactions. A normalized k2 (kN) was calculated as kN = kPCBz/kHCB. GC–MS analysis confirmed that the reactions were pure nucleophilic aromatic substitutions without side reactions.

  • 132. Qiu, Yanling
    et al.
    Strid, Anna
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bignert, Anders
    Zhu, Zhiliang
    Zhao, Jianfu
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanassiadis, Loannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Chlorinated and brominated organic contaminants in fish from Shanghai markets: A case study of human exposure2012Ingår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 89, nr 4, s. 458-466Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In the present study were two favorite edible fish species for local residents, i.e., mandarin fish and crawfish, collected from the Shanghai market and analyzed for selected organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), hexabromocyclododecane (HBCDD), polybrominated diphenyl ethers (PBDEs) and methoxylated PBDEs (MeO-PBDEs). Efforts were also made to identify the potential sources of these contaminants. Comparable concentrations of hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs) and HBCDD were found in muscle tissue of mandarin fish from Guangdong (GDF), the Pearl River Delta and from Taihu Lake (TLF), the Yangtze River Delta. Levels of chlordanes, PCBs and PBDEs were about one magnitude lower in TLF compared to GDF. The concentrations of OCPs in the butter-like gland of the crawfish (CFB) were 2-5 times of those in the crawfish muscle (CFM) while concentrations of PCBs, PBDEs and MeO-PBDEs were comparable. The different patterns and levels of chlorinated and brominated organo-halogen contaminants seen in mandarin fish from GDF and TLF indicates that different types of chemicals might be used in the two delta regions. The present study also shows a good correlation between the concentrations of hexachlorobenzene (HCB) and pentachloroanisol (PCA) in fish for the first time. Fish consumption limits based on chemical contaminants with non-carcinogenic effects were calculated. The estimated maximum daily consumption limit for GDF,TLF, CFM and CFB were 1.5, 2.6, 3.7 and 0.08 kg, respectively, indicating no significant risk regarding the persistent organic pollutants measured in the present study.

  • 133. Repouskou, Anastasia
    et al.
    Papadopoulou, Anastasia-Konstantina
    Panagiotidou, Emily
    Trichas, Panagiotis
    Lindh, Christian
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap.
    Gennings, Chris
    Bornehag, Carl-Gustaf
    Rüegg, Joëlle
    Kitraki, Efthymia
    Stamatakis, Antonios
    Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment2020Ingår i: Scientific Reports, E-ISSN 2045-2322, Vol. 10, nr 1, artikel-id 9367Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Accumulating evidence suggests that gestational exposure to endocrine disrupting chemicals (EDCs) may interfere with normal brain development and predispose for later dysfunctions. The current study focuses on the exposure impact of mixtures of EDCs that better mimics the real-life situation. We herein describe a mixture of phthalates, pesticides and bisphenol A (mixture N1) detected in pregnant women of the SELMA cohort and associated with language delay in their children. To study the long-term impact of developmental exposure to N1 on brain physiology and behavior we administered this mixture to mice throughout gestation at doses 0x, 0.5x, 10x, 100x and 500x the geometric mean of SELMA mothers' concentrations, and examined their offspring in adulthood. Mixture N1 exposure increased active coping during swimming stress in both sexes, increased locomotion and reduced social interaction in male progeny. The expression of corticosterone receptors, their regulator Fkbp5, corticotropin releasing hormone and its receptor, oxytocin and its receptor, estrogen receptor beta, serotonin receptors (Htr1a, Htr2a) and glutamate receptor subunit Grin2b, were modified in the limbic system of adult animals, in a region-specific, sexually-dimorphic and experience-dependent manner. Principal component analysis revealed gene clusters associated with the observed behavioral responses, mostly related to the stress axis. This integration of epidemiology-based data with an experimental model increases the evidence that prenatal exposure to EDC mixtures impacts later life brain functions.

  • 134. Rose, Melissa
    et al.
    Bennett, Deborah H.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Fängström, Britta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Pessah, Isaac N.
    Hertz-Picciotto, Irva
    PBDEs in 2-5 Year-Old Children from California and Associations with Diet and Indoor Environment2010Ingår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 44, nr 7, s. 2648-2653Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study determined the body burden of PBDEs in 100 California children, and evaluated associations with sociodemographic, household, and dietary factors. In national and international comparisons, California dust, breast milk, and human serum samples contain higher concentrations of PBDEs. Higher levels in children suggest exposure pathways depend upon age. Plasma samples were analyzed for PBDEs using GC/MS. Circulating levels of PBDEs were 10-to 1000-fold higher than similar aged populations in Mexico and Europe, 5-times higher than similar aged children across the U.S., and 2- to 10-fold higher than U.S. adults. Increased levels of higher-brominated congeners were associated with the recent purchase of new upholstered furniture or mattresses and consumption of pork. Concentrations of lower-brominated congeners increased with frequency of poultry consumption. Lower maternal education was independently and significantly associated with higher levels of most congeners in the children.

  • 135.
    Rydén, Andreas
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Nestor, Gustav
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Cuadra, Steven N
    Jakobsson, Kristina
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Marsh, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Synthesis and identification of hydroxylated polybrominated diphenyl ethers in human blood 2009Ingår i: Organohalogen Compounds, Vol. 71, Peking, 2009, s. 2044-2048Konferensbidrag (Refereegranskat)
    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 136.
    Rydén, Andreas
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Strid, Anna
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Occurrence and potential human exposure to brominated flame retardants at a Swedish smelter handling electronic scrapManuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Some well-known brominated flame retardants are common in electronic and electric devices, i.e. polybrominated diphenyl ethers (PBDEs), nowadays particularly the commercial DecaBDE, and tetrabromobisphenol A (TBBPA), but others are used as well. The PBDEs are ubiquitous environmental contaminants while the TBBPA is primarily reported as a contaminant of the abiotic compartments. In this study, personnel at a smelter handling large quantities of shredded printed circuit boards were assessed for potential elevated concentrations of PBDEs, TBBPA and other BFRs. Also dust, sampled at a few sites around the plant, was analysed for BFRs. The dominating BFRs in the dust were decabromodiphenyl ether (BDE-209) and TBBPA, while intermediate levels were indicated for bis(2,4,6-tribromophenoxy)ethane (BTBPE), decabromodiphenyl ethane (DBDPE) and hexabromobenzene (HBB) and only low concentrations of decabromobiphenyl (BB-209) and 2,4,6-tribromophenol (2,4,6-TBP). The workers all showed similar concentrations of the PBDE congeners in serum as recently determined for a Swedish control group. TBBPA was below limit of detection while 2,3,4,6-tetrabromophenol was present in all workers at rather high concentrations. It is yet not known from where this exposure originate, since the compound is not related to BFRs in the dust from the electronic scrap. It is clear that the workers are well protected from the emissions from the printed circuit boards, even though the volumes of electronic scrap handled at the smelter has increased significantly.

  • 137. Scheringer, M
    et al.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Fiedler, H
    Holoubek, I
    Suzuki, N
    Zetzsch, C
    The international panel on chemical pollution (IPC):2007Ingår i: 11th International Conference on Chemistry and the Environment: Chemistry, environment & human activity in civilization development, 2007, s. 193-Konferensbidrag (Övrigt vetenskapligt)
  • 138. Scheringer, M
    et al.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Fiedler, H
    Holoubek, I
    Suzuki, N
    Zetzsch, C
    The international panel on chemical pollution (IPCP): Background and perspectives2007Ingår i: Organohalogen Compounds: Dioxin 2007, 2007, s. 528-531Konferensbidrag (Refereegranskat)
  • 139. Scheringer, Martin
    et al.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    International panel on chemical pollution2009Övrigt (Övrig (populärvetenskap, debatt, mm))
  • 140. Silva, A. Vieira
    et al.
    Chu, I.
    Feeley, M.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap. Örebro University, Sweden.
    Håkansson, H.
    Öberg, M.
    Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption2022Ingår i: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 107, s. 123-139Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The toxicity of PCB-156 (2,3,3′,4,4′,5-hexachlorobiphenyl) was investigated in rats following subchronic dietary exposure. Groups of 10 male and female Sprague-Dawley rats were administered PCB-156 in the diet at 0, 0.01, 0.1, 1 or 10 ppm for 90 days. Dose-dependent increases were detected for the liver, lung and kidney weights, as well as for the liver EROD, PROD and UDPGT enzyme activities and liver uroporphyrin concentration. Dose-dependent decreases were observed in final body weight, body weight gain, and thymus weight. Apolar retinoid concentrations were decreased in the liver and lungs and increased in the kidneys. Histopathological examination of the liver, thyroid, and thymus showed mild to moderate dose-related changes.

    A LOAEL of 0.01 ppm was established, based on reduced apolar liver retinoid concentration. Benchmark dose-modelling corroborated the sensitivity of liver retinoid endpoints. The lower confidence limits (BMDL) for a 5% decrease in apolar liver retinoid concentrations were 0.0009 and 0.0007 ppm, respectively, in males and females, corresponding to a daily dose of 0.06 μg PCB-156 per kg body weight. Organizing dose-response data for the individual hepatic endpoints along the PCB-156 dosing scale revealed a sequence of events compatible with a causal link between depletion of apolar retinoids and the other liver biochemistry and pathology findings. Taken together, data suggest that the retinoid endpoints should be further evaluated for a causal relationship to PCB-induced liver toxicity and that retinoid system endpoints are identified and characterized to support health risk assessment in the emerging research fields of endocrine disruption and mixture toxicology.

  • 141. Smedje, Greta
    et al.
    Lindgren, Torsten
    Jakobsson, Kristina
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Flame Retardants in Airplanes2011Konferensbidrag (Refereegranskat)
  • 142. Smythe, Tristan A.
    et al.
    Su, Guanyong
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap.
    Letcher, Robert J.
    Metabolic transformation of environmentally-relevant brominated flame retardants in Fauna: A review2022Ingår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 161, artikel-id 107097Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Over the past few decades, production trends of the flame retardant (FR) industry, and specifically for brominated FRs (BFRs), is for the replacement of banned and regulated compounds with more highly brominated, higher molecular weight compounds including oligomeric and polymeric compounds. Chemical, biological, and environmental stability of BFRs has received some attention over the years but knowledge is currently lacking in the transformation potential and metabolism of replacement emerging or novel BFRs (E/NBFRs). For articles published since 2015, a systematic search strategy reviewed the existing literature on the direct (e.g., in vitro or in vivo) non-human BFR metabolism in fauna (animals). Of the 51 papers reviewed, and of the 75 known environmental BFRs, PBDEs were by far the most widely studied, followed by HBCDDs and TBBPA. Experimental protocols between studies showed large disparities in exposure or incubation times, age, sex, depuration periods, and of the absence of active controls used in in vitro experiments. Species selection emphasized non-standard test animals and/or field-collected animals making comparisons difficult. For in vitro studies, confounding variables were generally not taken into consideration (e.g., season and time of day of collection, pollution point-sources or human settlements). As of 2021 there remains essentially no information on the fate and metabolic pathways or kinetics for 30 of the 75 environmentally relevant E/BFRs. Regardless, there are clear species-specific and BFR-specific differences in metabolism and metabolite formation (e.g. BDE congeners and HBCDD isomers). Future in vitro and in vivo metabolism/biotransformation research on E/NBFRs is required to better understand their bioaccumulation and fate in exposed organisms. Also, studies should be conducted on well characterized lab (e.g., laboratory rodents, zebrafish) and commonly collected wildlife species used as captive models (crucian carp, Japanese quail, zebra finches and polar bears).

  • 143.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Svavarsson, Jörundur
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Brominated organic compounds in a high trophic Arctic fish species, Greenland shark (Somniosus microcephalus)2008Ingår i: 6:e Svensk-norskt miljökemiskt möte: SNMM 2008 22-24 September, 2008Konferensbidrag (Övrig (populärvetenskap, debatt, mm))
  • 144.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Svavarsson, Jörundur
    Bergman, Åke
    Brominated organic compounds in a high trophic arctic fish species, Greenland shark (Somniosus microcephalus)2008Ingår i: Organohalogen Compounds: pops in marine mammals: Levels, effects, trends, 2008, s. 817-820Konferensbidrag (Refereegranskat)
  • 145.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Athanasiadou, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Svavarsson, Jörundur
    University of Iceland, Institute of Biology.
    Päpke, Olaf
    Eurofins GfA, Hamburg.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
    Neutral and phenolic brominated organic compounds of natural and anthropogenic origin in Northeast Atlantic Greenland shark (Somniosus microcephalus)2010Ingår i: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 29, nr 12, s. 2653-2659Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In the present study, muscle and liver tissue from 10 female Greenland sharks (Somniosus microcephalus) collected in Icelandic waters were analyzed for neutral and phenolic brominated organic compounds, including polybrominated diphenyl ethers (PBDEs) and the structurally related methoxylated (MeO) and hydroxylated (OH) PBDEs. Hydroxylated PBDEs exist both as natural products and as metabolites of the anthropogenic PBDEs, whereas MeO-PBDEs appear to exclusively be of natural origin. Other compounds examined were 2′,6-dimethoxy-2,3′,4,5′-tetrabromodiphenyl ether (2′,6-diMeO-BDE68), 2,2′-dimethoxy-3,3′,5,5′-tetrabromobiphenyl (2,2′-diMeO-BB80), 2,4,6-tribromoanisol (2,4,6-TBA) and 2,4,6-tribromophenol, all of natural origin, although 2,4,6-TBA and its phenolic counterpart may also be of anthropogenic origin. The major brominated organic compound was 6-MeO-BDE47, and ΣMeO-PBDE ranged from 49 to 210 ng/g fat in muscle and from 55 to 200 ng/g fat in liver tissue. Total concentrations of PBDEs were lower than ΣMeO-PBDE, in all but one sample, ranging between 7.3 to 190 and 9.9 to 200 ng/g fat in muscle and liver, respectively, and major congeners were BDE-47, BDE-99, and BDE-100. Polybrominated diphenyl ethers were analyzed using both high- and low-resolution mass spectrometry (MS) as a quality assurance, and the results from this comparison were acceptable. In accordance with previous work on Greenland sharks, no size/age-related accumulation was observed. Differences seen in concentrations were instead assumed to be a reflection of different feeding habits among the individuals. Phenolic compounds were only formed/retained in trace amounts in the Greenland shark. Among the phenolic compounds studied were 6-OH-BDE47, 2′-OH-BDE68, and 2,4,6-tribromophenol, all detected in liver and the latter two in muscle

  • 146.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Bruhn, Christoffer
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Sverko, Ed
    Svavarsson, Joerundur
    Tomy, Gregg
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Brominated and chlorinated flame retardants in liver of Greenland shark (Somniosus microcephalus): 2013Ingår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 91, nr 2, s. 222-228Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Polybrominated diphenyl ethers (PBDEs) are known brominated flame retardants that have now been banned or phased out in many parts of the world. As a consequence, interest in the environmental occurrence of non-PBDE flame retardants has increased. In the present study several potential PBDE replacement products together with short chained chlorinated paraffins (SCCPs) were assessed in Greenland sharks accidentally caught in waters around Iceland between 2001 and 2003. Non-PBDE flame retardants detected were pentabromoethylbenzene (PBEB), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and 2,3,5,6-tetrabromo-p-xylene (TBX). The concentrations were lower than levels of BDE-47 but similar to other PBDE congeners previously reported in Greenland shark. The median concentrations of SCCPs was 430 ng g(-1) fat, similar to individual PCB congeners previously reported. This is the first report of SCCPs, BTBPE, PBEB and TBX in any shark species globally and confirms the usefulness of the Greenland shark as a screening species for environmental contamination in the Arctic and sub-Arctic environment.

  • 147.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Bruhn, Christoffer
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Sverko, Ed
    Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.
    Svavarsson, Jörundur
    Institute of Biology, University of Iceland.
    Tomy, Gregg
    Fresh water institute, Department of Fisheries and Oceans, Winnipeg, Manitoba, Canada.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Brominated and chlorinated flame retardants in liver of Greenland shark (Somniosus microcephalus)Manuskript (preprint) (Övrigt vetenskapligt)
  • 148.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Jörundsdóttir, Hrönn
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Päpke, Olaf
    Eurofins-ERGO Research, Geierstrasse 1, D-223 05 Hamburg, Germany.
    Svavarsson, Jörundur
    Institute of Biology, University of Iceland, IS-101 Reykjavík, Iceland.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljökemi.
    Dioxins and PCBs in Greenland shark (Somniosus microcephalus) from the North-East Atlantic2007Ingår i: Marine Pollution Bulletin, ISSN 0025-326X, E-ISSN 1879-3363, Vol. 54, nr 9, s. 1514-1522Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Greenland shark (Somniosus microcephalus) is a high-trophic fish species present in Arctic waters. The present study aimed to determine concentrations of polychlorinated dibenzo-p-dioxins and furans (PCDDs/Fs), dioxin-like (DL) PCBs and six non-dioxin-like (NDL) PCBs in muscle and liver from 10 female Greenland sharks collected between 2001 and 2003 from Icelandic waters. The mean total concentrations of PCDDs/Fs were 13 and 530 pg/g fat for muscle and liver, respectively, and show enrichment in the liver. Concentrations of DL-non-ortho PCBs were also higher in liver compared to muscle with mean concentrations of 7.8 and 0.36 ng/g fat, respectively. No enrichment in the liver was found for DL-mono-ortho- and NDL-PCBs. No correlation was found between the size range studied and total concentrations of the compounds analyzed. Total WHO-TEQs (PCDDs/Fs and DL-PCBs) ranged between 7.1–70 and 54–1500 pg/g fat in muscle and liver, respectively.

  • 149.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Smedje, Greta
    Athanassiadis, Ioannis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Lindgren, Torsten
    Lundgren, Håkan
    Jakobsson, Kristina
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Brominated flame retardant exposure of aircraft personnel2014Ingår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 116, s. 83-90Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The use of brominated flame retardants (BFRs) such as polybrominated diphenyl ethers (PBDEs) in aircraft is the result of high fire safety demands. Personnel working in or with aircraft might therefore be exposed to several BFRs. Previous studies have reported PBDE exposure in flight attendants and in passengers. One other group that may be subjected to significant BFR exposure via inhalation, are the aircraft maintenance workers. Personnel exposure both during flights and maintenance of aircraft, are investigated in the present study. Several BFRs were present in air and dust sampled during both the exposure scenarios; PBDEs, hexabromocyclododecane (HBCDD), decabromodiphenyl ethane (DBDPE) and 1,2-bis (2,4,6-tribromophenoxy) ethane. PBDEs were also analyzed in serum from pilots/cabin crew, maintenance workers and from a control group of individuals without any occupational aircraft exposure. Significantly higher concentrations of PBDEs were found in maintenance workers compared to pilots/cabin crew and control subjects with median total PBDE concentrations of 19, 6.8 and 6.6 pmol g(-1) lipids, respectively. Pilots and cabin crew had similar concentrations of most PBDEs as the control group, except for BDE-153 and BDE-154 which were significantly higher. Results indicate higher concentrations among some of the pilots compared to the cabin crew. It is however, evident that the cabin personnel have lower BFR exposures compared to maintenance workers that are exposed to such a degree that their blood levels are significantly different from the control group.

  • 150.
    Strid, Anna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Svavarsson, Jörundur
    Institute of Biology, University of Iceland.
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Selected organochlorine pesticides, PCBs and their methyl sulfonyl metabolites in Greenland shark (Somniosus microcephalus)Manuskript (preprint) (Övrigt vetenskapligt)
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