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  • 1251.
    Adlerz, Linda
    et al.
    Stockholm University, Faculty of Science, Department of Neurochemistry and Neurotoxicology.
    Soomets, Ursel
    Stockholm University, Faculty of Science, Department of Neurochemistry and Neurotoxicology. University of Tartu, Estonia.
    Holmlund, Linda
    Stockholm University, Faculty of Science, Department of Neurochemistry and Neurotoxicology.
    Virland, Saade
    Langel, Ülo
    Stockholm University, Faculty of Science, Department of Neurochemistry and Neurotoxicology.
    Iverfeldt, Kerstin
    Stockholm University, Faculty of Science, Department of Neurochemistry and Neurotoxicology.
    Down-regulation of amyloid precursor protein by peptide nucleic acid oligomer in cultured rat primary neurons and astrocytes2003In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 336, no 1, p. 55-59Article in journal (Refereed)
    Abstract [en]

    The amyloid precursor protein (APP) and its proteolytic cleavage products, the amyloid P peptides, have been implicated as a cause of Alzheimer's disease. Peptide nucleic acids (PNA), the DNA mimics, have been shown to block the expression of specific proteins at both transcriptional and translational levels. Generally, the cellular uptake of PNA is low. However, recent studies have indicated that the effect of unmodified antisense PNA uptake is more pronounced in nervous tissue. In this study we have shown that biotinylated PNA directed to the initiator codon region of the APP mRNA (-4 - +11) was taken up into the cytoplasm of primary rat cerebellar granule cells and cortical astrocytes, using fluorescence and confocal microscopy studies. Uptake of PNA was faster in neurons than in astrocytes. Western blotting analysis showed that APP was strongly down-regulated in both neurons and astrocytes. Thus, unmodified PNA can be used for studies on the function of APP in neurons and astrocytes.

  • 1252.
    Adnyani, Desak Putu Deni Putri
    Stockholm University, Faculty of Social Sciences, Department of Education.
    Professional Development for Pre-service Teacher: A Case Study of Professional Development Program for Pre-service Teacher in State University in Central Indonesia2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The present study was a case study which aimed at exploring pre-service teachers’ perceptions of PPG-SM3T program for their professional development. PPG-SM3T program is a professional development program for pre-service teacher in Indonesia. Research design of this study was quantitative design and used convenience sampling. The sample was 60 pre-service teachers who graduated from PPG-SM3T program in a state university in central Indonesia. Instrument used to collect data for the present study was questionnaire and analysis consisted of Principal Component Analysis, Reliability test, and Exploratory Data Analysis were done in order to analyse the data. From the results of analysis, it was found that generally pre-service teachers who took PPG-SM3T program in the mentioned university response positively toward the program. It was found to be very effective for most of them as a preparation to be professional teachers. Workshop and field teaching practice were two features in the program that particularly helpful to prepare them to be professional teacher. However, it was also found that more supervision is needed for pre-service teacher during the program as well as non-teaching activities. Some specific cases also need to be considered for future improvement.

  • 1253. Adolfson, Malin
    et al.
    Laseen, Stefan
    Linde, Jesper
    Svensson, Lars E. O.
    Stockholm University, Faculty of Social Sciences, Institute for International Economic Studies. Stockholm School of Economics, Sweden; NBER, United States.
    Monetary policy trade-offs in an estimated open-economy DSGE model2014In: Journal of Economic Dynamics and Control, ISSN 0165-1889, E-ISSN 1879-1743, Vol. 42, p. 33-49Article in journal (Refereed)
    Abstract [en]

    This paper studies the trade-offs between stabilizing CPI inflation and alternative measures of the output gap in Ramses, the Riksbank's estimated dynamic stochastic general equilibrium (DSGE) model of a small open economy. Our main finding is that the trade-off between stabilizing CPI inflation and the output gap strongly depends on which concept of potential output in the output gap between output and potential output is used in the loss function. If potential output is defined as a smooth trend this trade-off is much more pronounced compared to the case when potential output is defined as the output level that would prevail if prices and wages were flexible.

  • 1254. Adolfson, Malin
    et al.
    Laseen, Stefan
    Linde, Jesper
    Villani, Mattias
    Stockholm University, Faculty of Social Sciences, Department of Statistics.
    Bayesian estimation of an open economy DSGE model with incomplete pass-through2007In: Journal of International Economics, ISSN 0022-1996, E-ISSN 1873-0353, Vol. 72, no 2, p. 481-511Article in journal (Refereed)
    Abstract [en]

    In this paper, we develop a dynamic stochastic general equilibrium (DSGE) model for an open economy, and estimate it on Euro area data using Bayesian estimation techniques. The model incorporates several open economy features, as well as a number of nominal and real frictions that have proven to be important for the empirical fit of closed economy models. The paper offers: i) a theoretical development of the standard DSGE model into an open economy setting, ii) Bayesian estimation of the model, including assessments of the relative importance of various shocks and frictions for explaining the dynamic development of an open economy, and iii) an evaluation of the model's empirical properties using standard validation methods.

  • 1255. Adolfson, Malin
    et al.
    Laseen, Stefan
    Linde, Jesper
    Villani, Mattias
    Stockholm University, Faculty of Social Sciences, Department of Statistics.
    Empirical properties of closed- and open-economy DSGE models of the Euro area2008In: Macroeconomic dynamics (Print), ISSN 1365-1005, E-ISSN 1469-8056, Vol. 12, p. 2-19Article in journal (Refereed)
    Abstract [en]

    In this paper, we compare the empirical proper-ties of closed- and open-economy DSGE models estimated on Euro area data. The comparison is made along several dimensions; we examine the models in terms of their marginal likelihoods, forecasting performance, variance decompositions, and their transmission mechanisms of monetary policy.

  • 1256. Adolfson, Malin
    et al.
    Laséen, Stefan
    Lindé, Jesper
    Svensson, Lars E. O.
    Stockholm University, Faculty of Social Sciences, Institute for International Economic Studies.
    Optimal Money Policy in an Operational Medium-Sized DSGE Model2011In: Journal of Money, Credit and Banking, ISSN 0022-2879, E-ISSN 1538-4616, Vol. 43, p. 1287-1331Article in journal (Refereed)
    Abstract [en]

    We show how to construct optimal policy projections in Ramses, the Riksbank's open-economy medium-sized dynamic stochastic general equilibrium model for forecasting and policy analysis. Bayesian estimation of the parameters of the model indicates that they are relatively invariant to alternative policy assumptions and supports our view that the model parameters may be regarded as unaffected by the monetary policy specification. We discuss how monetary policy, and in particular the choice of output gap measure, affects the transmission of shocks. Finally, we use the model to assess the recent Great Recession in the world economy and how its impact on the economic development in Sweden depends on the conduct of monetary policy. This provides an illustration on how Rames incoporates large international spillover effects.

  • 1257. Adolfson, Malin
    et al.
    Linde, Jesper
    Villani, Mattias
    Stockholm University, Faculty of Social Sciences, Department of Statistics.
    Bayesian analysis of DSGE models: Some comments2007In: Econometric Reviews, ISSN 0747-4938, E-ISSN 1532-4168, Vol. 26, no 2-4, p. 173-185Article in journal (Refereed)
    Abstract [en]

    Sungbae An and Frank Schorfheide have provided an excellent review of the main elements of Bayesian inference in Dynamic Stochastic General Equilibrium (DSGE) models. Bayesian methods have, for reasons clearly outlined in the paper a very natural role to flay in DSGE analysis, and the appeal of the Bayesian paradigm is indeed strongly evidenced by the flood of empirical applications in the area over the last couple of years. We expect their paper to be the natural starting point for applied economists interested in learning about Bayesian techniques for analyzing DSGE models, and as such the paper is likely to have a strong influence on what will be considered best practice for estimating DSGE models. The authors have, for good reasons, chosen a stylized six-equation model to present the methodology. We shall use here the large-scale model in Adolfson et al. (2005), henceforth ALLV, to illustrate a few econometric problems which we have found to be especially important as the size of the model increases. The model in ALLV is an open economy extension of the closed economy model in Christiano et al. (2005). It consists of 25 log-linearized equations, which can be written as a state space representation With 60 state variables, many of them unobserved. Fifteen observed unfiltered time series are used to estimate 51 structural parameters. An additional complication compared to the model in An and Schorfheide's paper is that some of the coefficients in the measurement equation are non-linear functions of the structural parameters. The model is currently the main vehicle for policy analysis at Sveriges Riksbank (Central Bank of Sweden) and similar models are being developed in many other policy institutions, which testifies to the model's practical relevance. The version considered here is estimated on Euro area data over the period 1980Q1-2002Q4. We refer to ALLV for details.

  • 1258. Adolfson, Malin
    et al.
    Linde, Jesper
    Villani, Mattias
    Stockholm University, Faculty of Social Sciences, Department of Statistics.
    Forecasting performance of an open economy DSGE model2007In: Econometric Reviews, ISSN 0747-4938, E-ISSN 1532-4168, Vol. 26, no 04-feb, p. 289-328Article in journal (Refereed)
    Abstract [en]

    This paper analyzes the forecasting performance of an open economy dynamic stochastic general equilibrium (DSGE) model, estimated with Bayesian methods, for the Euro area during 1994Q1-2002Q4. We compare the DSGE model and a few variants of this model to various reduced form forecasting models such as vector autoregressions (VARs) and vector error correction models (VECM), estimated both by maximum likelihood and, two different Bayesian approaches, and traditional benchmark models, e.g., the random. walk. The accuracy of point forecasts, interval forecasts and the predictive distribution as a whole are assessed in, an out-of-sample rolling event evaluation using several univariate and multivariate measures. The results show that the open economy DSGE model compares well with more empirical models and thus that the tension between, rigor and fit in older generations of DSGE models is no longer present. We also critically examine the role of Bayesian model probabilities and other frequently used low-dimensional summaries, e.g., the log determinant statistic, as measures of overall forecasting performance.

  • 1259. Adolfsson Boman, Marianne
    et al.
    Eriksson, Inger
    Stockholm University, Faculty of Social Sciences, Department of Education.
    Hverven, Mona
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Jansson, Anders
    Stockholm University, Faculty of Social Sciences, Department of Special Education.
    Tambour, Torbjörn
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Att introducera likhetstecken i ett algebraiskt sammanhang för elever i årskurs 12013In: Forskning om undervisning och lärande, ISSN 2000-9674, E-ISSN 2001-6131, no 10, p. 29-49Article in journal (Refereed)
    Abstract [sv]

    Artikeln bygger på data från forsknings- och utvecklingsprojektet (FoU) ”Utveckling av matematiskt tänkande – expanderande uppgifter i nybörjarundervisningen” där lärare från Skärsätra skola tillsammans med forskare från Stockholms universitet genomförde ett undervisningsexperiment i syfte att introducera algebra i nybörjarundervisningen.

  • 1260. Adolfsson, E
    et al.
    Shen, Z
    Stockholm University.
    Densification of zirconia-hydroxyapatite ceramics without phase changes2006In: Bioceramics 18 PTS 1 and PTS 2, Vol. 309-311, p. 1141-1144Article in journal (Refereed)
  • 1261.
    Adolfsson, Emma
    Stockholm University, Faculty of Humanities, Department of Language Education.
    Barn, skriftspråk och skola: Fyra lärare i förskoleklass och årskurs 1 berättar om sitt arbete med barns literacyutveckling.2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats syftar till att belysa och diskutera lärares didaktiska val i arbetet med barns literacyutveckling i förskoleklass respektive årskurs 1. Som grund ligger ett sociokulturellt perspektiv på lärande samt forskning om barns literacyutveckling, och med utgångspunkt i detta samt i min studie har didaktiska val i arbetet med barns literacyutveckling kunnat belysas och diskuteras.

    Inför min studie ställde jag mig den vida forskningsfrågan: Hur arbetar ett par lärare i förskoleklass respektive årskurs 1 i två olika skolor för att befrämja barns literacyutveckling och vilka skäl anger de till detta? Studien bygger på kvalitativa intervjuer med och observationer av fyra olika lärare från två olika skolor, som alla är eller nyligen varit verksamma i förskoleklass eller årskurs 1. I analysen av lärarnas tankar kring arbetet med barns literacyutveckling har olika kategorier vuxit fram, där den mest övergripande, som genomsyrar hela analysen och diskussionen, kom att bli huruvida arbetet med barns literacyutveckling sker i för barnen meningsfulla sammanhang eller ej.

    I min studie framkom det att lärarna delvis arbetar enligt traditionell behavioristisk teori och ett syntetiskt synsätt, men också enligt en modernare sociokulturell teori och ett analytiskt synsätt. Att utgå från en meningsfull helhet, som läsning med meningsinnehåll, eget skrivande samt samtal och lek/dramatisering, och att i detta jobba med de viktiga beståndsdelarna, det vill säga bokstav ljudförhållandet, lyfts fram i detta arbete. Något annat som lyfts fram är hur lärarna individualiserar så att arbetet med barnens literacyutveckling ska bli meningsfullt för eleverna, samt hur de ser på förskoleklassens och årskurs 1:s roll i mötet med eleverna.

  • 1262.
    Adolfsson, Erik
    Stockholm University.
    Phase Stability and Preparations of Oxide-Apatite Composites1999Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In the preparation of bioactive composites containing hydroxyapatite, Ca5(PO4)3(OH), and an oxide it has been a problem to prevent the hydroxyapatite from decomposing in the sintering process. This is because H2O is evolved when hydroxyapatite is heated, implying that the occupied OH- positions in hydroxyapatite structure are partly replaced by vacancies and O2- ions. The thermal stability of hydroxyapatite was found to depend on the fraction of vacancies and O2- ions present. The decomposition of the hydroxyapatite is initiated when a critical fraction of the OH- ions has been lost, and it is not specifically related to the temperature applied or atmosphere used. The decomposition temperature of hydroxyapatite and fluoride-containing apatite, Ca5(PO4)3(OH)1-xFx, in the presence of alumina has been studied and found to increase with increasing x value in Ca5(PO4)3(OH)1-xFx. By combining this observation with thermogravimetric studies of hydroxyapatite and Ca5(PO4)3OH1-xFxsamples, it was concluded that the decomposition of hydroxyapatite in the presence of alumina can be described by the following reactions:

    Ca5(PO4)3(OH) --> Ca5(PO4)3(OH)1-xOx/2 + x/2 H20

    2 Ca5(PO4)3(OH)1-xOx/2+ Al2O3 --> 3 Ca3(PO4)2 + CaAl2O4 + (1-x) H2O

    With the use of a closed system for sintering the aluminañapatite composites, the loss of water can be reduced. The equilibrium in the first reaction will then be shifted to the left, and the second reaction will not occur. This implies that a higher sintering temperature can be used to densify an aluminañhydroxyapatite composite. Accordingly, composites of alumina and zirconia, respectively, with hydroxyapatite could be hot isostatically pressed (HIPed) in a closed system at 1200oC and at a pressure of 160 MPa without any detectable decomposition of the hydroxyapatite. Another way to avoid excess formation of vacancies is to replace some of the OH-ions with F-. This implies that the equilibrium in the first reaction given above is shifted to the left, thus improving the thermal stability of the apatite.

    The main result of this thesis work is a more detailed understanding of the reaction between the oxide and hydroxyapatite, which has made it possible to prepare densified oxide-hydroxyapatite composites without decomposition of the hydroxyapatite phase.

  • 1263. Adolfsson, Erik
    et al.
    Shen, Zhijian
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Effects of granule density on strength and granule related defects in zirconia2012In: Journal of the European Ceramic Society, ISSN 0955-2219, E-ISSN 1873-619X, Vol. 32, no 11, p. 2653-2659Article in journal (Refereed)
    Abstract [en]

    A suspension of zirconia powder (TZ3YSE) with a solids loading of 50 vol% was prepared by ball milling. Binders were added and some of the suspension was diluted to 40, 30 and 20 vol% before freeze granulation was performed. A spray dried material (TZ3YSEB) was used as a reference. The pore size distribution of the different granules was evaluated and from the microstructure it was shown that inhomogeneities were present in both the freeze granulated as well as in the spray dried granules. In addition, the density, microstructure as well as the strength of sintered materials prepared from the granules were studied. The results showed that a high green density or sintered density was not sufficient in order to achieve a high strength material. It was further shown that the strength was significantly influenced by the granule density and not by the inhomogeneities found in the granules.

  • 1264.
    Adolfsson, Hans
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Alkene and Imino Reductions by Organocatalysis2008In: Modern Reduction Methods, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim , 2008, p. 341-361Chapter in book (Refereed)
  • 1265.
    Adolfsson, Hans
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Product Class 2: Epoxides (Oxiranes): Synthesis from Alkenes by Metal-Mediated Oxidation2008In: Houben-Weyl Methods of Molecular Transformations: Compounds with One Saturated Carbon-Heteroatom Bond, Georg Thieme Verlag KG, Stuttgart , 2008, p. 227-276Chapter in book (Refereed)
  • 1266.
    Adolfsson, Hans
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Transition metal-catalyzed epoxidation of alkenes2010In: Modern Oxidation Methods / [ed] Jan-Erling Bäckvall, Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA , 2010, 2, p. 37-84Chapter in book (Other academic)
  • 1267.
    Adolfsson, Herbert
    Stockholm University, Faculty of Humanities.
    Liber epistularum Guidonis de Basochis: edidit et adnotationibus instruxit1969Doctoral thesis, monograph (Other academic)
  • 1268.
    Adolfsson, Johanna
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    The Power of the Palestinian Landscape: An exploratory study of the functions of power using aerial image interpretation2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The Palestinian region is changing rapidly, with both economic and cultural consequences. One way of approaching this very political process is thru the concept of landscape. By viewing the region as a multiprocessual, dynamic landscape the analysis allows for a holistic read where historical and contemporary projections, interpretations and notions of power are fused. This thesis draws on the scholarly fields of humanistic landscape research and aerial image interpretation as well as theories of orientalism and power. A case study of two regions of the West Bank is performed; interviews and observations provide localized knowledge that is then used in open-access image interpretation. By performing image interpretations this thesis explores the power embedded in mapping and the possible inclinations the development towards open-access geospatial analytic tools could have on the functions of power in the Palestinian landscape. By investigating the spatial configuration of the Palestinian landscape and tracing its roots this thesis finds four major themes that are particularly pivotal in the processual change of the Palestinian landscape: the Israeli/Palestinian time-space, the blurring of the conflict, the dynamics of the frontier region and the orientalist gaze. 

  • 1269.
    Adolfsson, Magnus
    et al.
    Stockholm University, Faculty of Social Sciences, School of Business.
    Escriche Bjare, Mikael
    Stockholm University, Faculty of Social Sciences, School of Business.
    Lindström, Stefan
    Stockholm University, Faculty of Social Sciences, School of Business.
    Aktiv förvaltning: En studie av Sverigefonder och deras performance2001Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studien undersöker fondförvaltares aktivitetsgrad och deras avgifterna i förhållande till fondernas performance. Många förvaltare marknadsför sina fonder som aktivt förvaltade, men uppvisar ett resultat i vår undersökning som lämnar utrymme för diskussion.

  • 1270.
    Adolfsson, Magnus
    et al.
    Stockholm University, Faculty of Social Sciences, School of Business.
    Kjernsvik, Johan
    Stockholm University, Faculty of Social Sciences, School of Business.
    Realoptioner: - i teori och praktik2003Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 1271.
    Adolfsson, Maria
    Stockholm University, Faculty of Humanities, Department of Ethnology, History of Religions and Gender Studies.
    Fäderneslandets kännedom: om svenska ortsbeskrivningsprojekt och ämbetsmäns folklivsskildringar under 1700- och 1800-talet2000Doctoral thesis, monograph (Other academic)
    Abstract [en]

    During the period c. 1720-1900 a large quantity of descriptions of rural areas in Sweden were set down on paper. Some 700 local descriptions were printed at the time or have appeared in print during the twentieth century. The most common geographical unit for local descriptions is the parish. As a rule the author was a public servant, and the clergy in particular were industrious local descriptive writers.

    In part the aim of this thesis is to present the Swedish local description projects and local descriptive literature as a phenomenon of the eighteenth and nineteenth centuries. A further aim is to investigate the way the folklife descriptions which come into most of the local descriptions are constituted for the period c. 1750-1850.

    The local descriptions which form the main object of analysis and discussion in the thesis comprise contemporary delineations which came into being in order to achieve an economic-topographical description of the country, where agriculture and the individual economy of the common man were the focus of attention. These descriptions to a certain extent define the problems the authors associate with the economic life of the countryside and way of life of the population.

    Local descriptions constitute a particular category of geographical delineation and have either come into being on the author's own initiative, in reply to a particular institution or the questionnaire of a particular person, or as an academic dissertation. The authors of local descriptions are in most cases connected with the area they describe. The work was mainly carried out by voluntary effort.

    The idea of the need for a national and methodically organised inventorying of resources associated with the physical environment was the most important reason for undertaking local description projects. These Swedish local descriptions were one of several important cornerstones in the endeavours of the State to increase the population, income from taxes, and welfare in general. Local descriptions constituted materialised visions of optimism for growth, and a better and happier future for the country and its inhabitants, in the modern Sweden which was beginning to emerge in the mid-eighteenth century. Another overall aim was to improve the moral status of the peasantry and promote in them a moral and virtuous way of life. The enlightenment of the common man thereby became a didactic matter, touched on in many local descriptions. This process was not unique to Sweden; corresponding efforts took place in a whole host of other European countries.

    The selection of sixty or so local descriptions studied in this thesis are characterised to a great extent by dualistic tendencies on the part of the public servants in their writings about, and interpretations of, peasant character and the state of the agricultural economy. Descriptions of the noble and exemplary true Swedish peasant faithful to his king, hospitable and honest are combined with descriptions of those same people's immodest consumption of spirits, lack of foresight, inclination to the "superstitious", and pernicious love of material things. In actual fact local descriptive writings consisted of an encounter: on the one side between more abstract and political discourses which contained thoughts of an ideal social organisation and the true nature of a population; while on the other side were the everyday experiences of separate writers vis a vis the qualities and situations of the local peasant population, compiled from their position as objectively observing public servants.

  • 1272.
    Adolfsson, Maya
    Stockholm University, Faculty of Law, Department of Law.
    Våldtäkten - socialt legal men formellt olaglig: en radikalfeministisk analys av sexualstraffrättens förmåga att avhjälpa förtryckande könsmaktsstrukturer2015Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 1273.
    Adolfsson, Tomas
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Psychology.
    Ledin, Mikael
    Stockholm University, Faculty of Social Sciences, Department of Psychology.
    ”Terapi är något man måste göra hela tiden”: Hur psykoterapiklienter i KBT och PDT integrerar och använder sig av erfarenheter från terapin i sin vardag2007Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    I psykoterapidebatten finns två läger, som hävdar gemensamma respektive specifika faktorers betydelse för utfallet i psykoterapi. I forskningen finns brist på studier som lyfter fram klientens subjektiva upplevelse av terapins nytta. Uppsatsens syfte var att undersöka hur psykoterapiklienter integrerar och använder erfarenheter från terapin i sin vardag, samt vilka faktorer som har underlättat terapiprocessen. Tretton klienter som genomgått psykodynamisk terapi (PDT) eller kognitiv beteendeterapi (KBT) intervjuades. Data analyserades tematiskt och sammanställdes som fyra idealtyper. Resultaten visade att gruppen PDT-klienters breda problemformuleringar utvecklades via förändrade tankemönster till konkreta användningsområden. KBT-klienternas avgränsade problemformulering utvecklades via bemästrande av avgränsat problem till generaliserad användning av strategier. Viktiga gemensamma inslag i terapiprocessen var insikt, förmåga att se sig själv utifrån och möjlighet eller vilja till konkret applicering av nya erfarenheter. Underlättande faktorer var klientens beredskap och aktiva deltagande, i kombination med förtroende för terapeuten och tro på terapimodellen. Användning som alternativt utfallsmått diskuteras, liksom resultatens implikationer för terapeutisk verksamhet och synen på utvärdering av psykoterapi.

  • 1274.
    Adolfsson-Erici,
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Allmyr,
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Antibakteriellt behandlade konsumentprodukter - källa till exponering av människa och miljö2007Report (Other (popular science, discussion, etc.))
  • 1275.
    Adolfsson-Erici,
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Allmyr,
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Andersson, H.
    Glynn, A.
    Sources of triclosan exposure to humans2007In: SETAC News: May 20-24, 2007Conference paper (Other (popular science, discussion, etc.))
  • 1276.
    Adolfsson-Erici,
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Alsberg,
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Magnér,
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Gunnarsson, L.
    Larsson, D.G.J.
    Pharmacuticals in fish bile2007In: SNMM: March 12-14 2007, 2007Conference paper (Other (popular science, discussion, etc.))
  • 1277.
    Adolfsson-Erici,
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Alsberg,
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Magnér,
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Gunnarsson, L.
    Larsson, D.G.J.
    Tracing pharmaceutical residues from humans to fish2007In: SETAC News: May 20-24, 2007Conference paper (Other (popular science, discussion, etc.))
  • 1278.
    Adolfsson-Erici, M.
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Pettersson, M.
    Parkkonen, J.
    Sturve, J.
    Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden2002In: Chemosphere, ISSN 0366-7111, Vol. 46, no 9-10, p. 1485-1489Article in journal (Refereed)
  • 1279.
    Adolfsson-Erici, Margaretha
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Fish bile in environmental analysis2005Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This work explores the usefulness of fish bile analysis in combination with biomarkers for identifying and evaluating new environmental contaminants in the aquatic environment. It illustrates how bile analysis can be used together with biomarkers to assess the causes of estrogenic effects, to identify chemicals in the aquatic environment that are taken up by fish, and to monitor environmental exposure.

    In a first application, fish exposed to sewage treatment plant effluent were studied. Elevated levels of vitellogenin in the exposed fish demonstrated that estrogenic effects occurred. Several estrogen disrupting substances were identified in the fish bile, and analysis of water samples confirmed that these substances were present in the effluent. The synthetic estrogen 17a-ethinylestradiol, which is known to be present in sewage treatment plant effluent, was shown for the first time to be taken up by fish. Considering the reported potencies of the detected substances, it was concluded that 17a-ethinylestradiol was the major contributor to the estrogenic effects.

    Chemical analysis of bile was used to identify rubber additives that were released from tires immersed in water. The bile of rainbow trout held in the water contained high levels of metabolites of PAHs and aromatic nitrogen compounds. Several biomarkers were also measured in the exposed fish, and EROD induction and oxidative stress were observed. Based on the bile analysis observations together with knowledge of toxicological mechanisms, it was postulated that the EROD induction was due to the PAHs, while aromatic nitrogen compounds caused the oxidative stress.

    Resin acids in fish bile proved to be a good indicator of exposure in a chronic long-term study of rainbow trout exposed to effluent from a total chlorine free (TCF) pulp mill. Elevated levels of GST (gluthatione-S-transferase) and GR (gluthatione reductase) activity, and the presence of DNA adducts after a two month recovery period, indicated that compounds in the pulp mill effluents have persistent effects. In addition to characterising the exposure of the fish to the effluent, the analysis of the resin acids in the bile provided evidence of accidents in the pulp mill that the existing process monitoring system had not detected.

    Resin acids in bile were also found to be a valuable indicator of exposure to pulp mill effluents for eelpout living in the Baltic Sea. A correlation between resin acid levels in bile and skewed sex ratios provided an important link in the chain of evidence that substances in the pulp mill effluents cause male bias of the eelpout embryos.

    A particularly good example of the potential of bile analysis was the identification of a previously unknown environmental contaminant. A large peak was observed in the bile extracts of fish that had been exposed to sewage treatment plant effluent. This peak was identified as triclosan, which demonstrated its presence in sewage treatment plant effluent. Other work went on to show that it is a common contaminant of the aquatic environment. The ability of fish to concentrate contaminant metabolites in bile to levels very much higher than in the environment, and the comparatively low levels of analytic interferences, make bile a particularly attractive matrix to search for new, unknown organic pollutants

  • 1280.
    Adolfsson-Erici, Margaretha
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Åkerman, Gun
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Jahnke, Annika
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Mayer, Philipp
    McLachlan, Michael S.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    A flow-through passive dosing system for continuously supplying aqueous solutions of hydrophobic chemicals to bioconcentration and aquatic toxicity tests2012In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 86, no 6, p. 593-599Article in journal (Refereed)
    Abstract [en]

    A continuous supply of water with defined stable concentrations of hydrophobic chemicals is a requirement in a range of laboratory tests such as the OECD 305 protocol for determining the bioconcentration factor in fish. Satisfying this requirement continues to be a challenge, particularly for hydrophobic chemicals. Here we present a novel solution based on equilibrium passive dosing. It employs a commercially available unit consisting of similar to 16000 polydimethylsiloxane (PDMS) tubes connected to two manifolds. The chemicals are loaded into the unit by repeatedly perfusing it with a methanol solution of the substances that is progressively diluted with water. Thereafter the unit is perfused with water and the chemicals partition from the unit into the water. The system was tested with nine chemicals with logK(ow) ranging from 4.1 to 6.3. The aqueous concentrations generated were shown to be largely independent of the water flow rate, and the unit to unit reproducibility was within a factor of similar to 2. In continuous flow experiments the aqueous concentrations of most of the study chemicals remained constant over 8 d. A model was assembled that allows prediction of the operating characteristics of the system from the logKow or PDMS/water partition coefficient of the chemical. The system is a simple, safe, predictable and flexible tool that generates stable aqueous concentrations of hydrophobic chemicals.

  • 1281.
    Adolfsson-Erici, Margaretha
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Åkerman, Gun
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    McLachlan, Michael S.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Internal Benchmarking Improves Precision and Reduces Animal Requirements for Determination of Fish Bioconcentration Factors2012In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 46, no 15, p. 8205-8211Article in journal (Refereed)
    Abstract [en]

    The enactment of new chemical regulations has generated a large need for the measurement of the fish bioconcentration factor (BCF). Past experience shows that the BCF determination lacks precision, requires large numbers of fish, and is costly. A new protocol was tested that shortens the experiment from up to 12 weeks for existing protocols to 2 weeks and reduces the number of fish by a factor of 5, while introducing internal benchmarking for the BCF determination. Rainbow trout were simultaneously exposed to 11 chemicals. The BCFs were quantified using one of the test chemicals, musk xylene, as a benchmark. These were compared with BCFs measured in a parallel experiment based on the OECD 305 guideline. The agreement was <20% for five chemicals and between 20%-25% for two further, while two chemicals lay outside the BCF operating window of the experiment and one was lost due to analytical difficulties. This agreement is better than that observed in a BCF Gold Standard Database. Internal benchmarking allows the improvement of the precision of BCF determination in parallel to large reduction in costs and fish requirements.

  • 1282.
    Adolfsson-Erici, Margaretha
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Åkerman, Gun
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    McLachlan, Michael S.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    In-vivo passive sampling to measure elimination kinetics in bioaccumulation tests2012In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 88, no 1, p. 62-68Article in journal (Refereed)
    Abstract [en]

    The application of in-tissue passive sampling to quantify chemical kinetics in fish bioconcentration experiments was investigated. A passive sampler consisting of an acupuncture needle covered with a PDMS tube was developed together with a method for its deployment in rainbow trout. The time to steady state for chemical uptake into the passive sampler was >1 d, so it was employed as a kinetically limited sampler with a deployment time of 2 h. The passive sampler was employed in parallel with the established whole tissue extraction method to study the elimination kinetics of 10 diverse chemicals in rainbow trout. 4-n-nonylphenol and 2,4,6-tri-tert-butylphenol were close to or below the limit of quantification in the sampler. For chlorpyrifos, musk xylene, hexachlorobenzene, 2,5-dichlorobiphenyl and p,p'-DDT. the elimination rate constants determined with the passive sampler method and the established method agreed within 18%. Poorer agreement (35%) was observed for 2,3,4-trichloroanisole and p-diisopropylbenzene because fewer data were obtained with the passive sampling method due to its lower sensitivity. The work shows that in-tissue passive sampling can be employed to measure contaminant elimination kinetics in fish. This opens up the possibility of studying contaminant kinetics in individual fish, thereby reducing the fish requirements and analytical costs for the determination of bioconcentration factors.

  • 1283.
    Adolfsson-Erici, Margaretha
    et al.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Åkerman, Gun
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    McLachlan, Michael S.
    Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
    Measuring bioconcentration factors in fish using exposure to multiple chemicals and internal benchmarking to correct for growth dilution2012In: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 31, no 8, p. 1853-1860Article in journal (Refereed)
    Abstract [en]

    Modern chemical legislation requires measuring the bioconcentration factor (BCF) of large numbers of chemicals in fish. The BCF must be corrected for growth dilution, because fish growth rates vary between laboratories. Two hypotheses were tested: (1) that BCFs of multiple chemicals can be measured simultaneously in one experiment, and (2) that internal benchmarking using a conservative test substance in the chemical mixture can be used to correct for growth dilution. Bioconcentration experiments were conducted following major elements of the OECD 305 guideline. Fish were simultaneously exposed to 11 chemicals selected to cover a range of BCFs and susceptibility to biotransformation. A method was developed to calculate the growth-corrected elimination rate constant from the concentration ratio of the analyte and a benchmarking chemical for which growth dilution dominated other elimination mechanisms. This method was applied to the experimental data using hexachlorobenzene as the benchmarking chemical. The growth dilution correction lowered the apparent elimination rate constants by between 5% and a factor of four for eight chemicals, while for two chemicals the growth-corrected elimination rate constant was not significantly different from zero. The benchmarking method reduced the uncertainty in the elimination rate constant compared to the existing method for growth dilution correction. The BCFs from exposing fish to 10 chemicals at once were consistent with BCF values from single-chemical exposures from the literature, supporting hypothesis 1. Environ. Toxicol. Chem. 2012; 31: 18531860. (c) 2012 SETAC

  • 1284. Adolphsen, Jens Q.
    et al.
    Gil, Vanesa
    Sudireddy, Bhaskar R.
    Bergström, Lennart
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Characterisation and processing of aqueous LaNi0.6Fe0.4O3 Suspensions into Porous Electrode Layers for Alkaline Water Electrolysis2019In: Journal of the European Ceramic Society, ISSN 0955-2219, E-ISSN 1873-619X, Vol. 39, no 4, p. 1271-1278Article in journal (Refereed)
    Abstract [en]

    The colloidal properties and processing of aqueous LaNi0.6.Fe0.4O3 suspensions into electrode layers with hierarchical pore sizes has been investigated by light scattering, electron microscopy and rheology. We found that the colloidal stability of the oxide particles and the resulting microstructure of the electrode layers were similar when dispersing the particles at their intrinsic pH, or when adding polyvinylpyrrolidone. The addition of the ammonium salt of poly(methaacrylic acid) resulted in a poor colloidal stability and the concentrated suspensions became viscoelastic during processing. Addition of rice starch resulted in an increase of the porosity but the cast electrode layers cracked and delaminated.

  • 1285.
    Adolphson, Margareta
    Stockholm University, Faculty of Humanities, Department of Education in Humanities and Social Sciences.
    Livsfrågor i praktiken: Utdrag ur en forskningsrapport2009In: Religion & Livsfrågor, ISSN 0348-8918, Vol. 40, no 4, p. 18-19Article in journal (Refereed)
  • 1286.
    Adolphson, Margareta
    Stockholm University, Faculty of Humanities, Department of Education in Humanities and Social Sciences.
    Två terminer - eller jag som trodde att jag kunde...2009Report (Other academic)
  • 1287.
    Adrait, Annie
    et al.
    Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
    Öhrström, Maria
    Barra, Anne-Laure
    The High Field Laboratory, CNRS/MPI, Grenoble, France.
    Thelander, Lars
    Department of Medical Biochemistry and Biophysicis, Umeå University.
    Gräslund, Astrid
    Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
    EPR studies on a stable sulfinyl radical observed in the iron-oxygen reconstituted Y177F/I263C protein double mutant of ribonucleotide reductase from mouse2002In: Biochemistry, ISSN 0006-2960, E-ISSN 1520-4995, Vol. 41, no 20, p. 6510-6516Article in journal (Refereed)
    Abstract [en]

    Ribonucleotide reductase (RNR) catalyzes the biosynthesis of deoxyribonucleotides. The active enzyme contains a diiron center and a tyrosyl free radical required for enzyme activity. The radical is located at Y177 in the R2 protein of mouse RNR. The radical is formed concomitantly with the μ-oxo-bridged diferric center in a reconstitution reaction between ferrous iron and molecular oxygen in the protein. EPR at 9.6 and 285 GHz was used to investigate the reconstitution reaction in the double-mutant Y177F/I263C of mouse protein R2. The aim was to produce a protein-linked radical derived from the Cys residue in the mutant protein to investigate its formation and characteristics. The mutation Y177F hinders normal radical formation at Y177, and the I263C mutation places a Cys residue at the same distance from the iron center as Y177 in the native protein. In the reconstitution reaction, we observed small amounts of a transient radical with a probable assignment to a peroxy radical, followed by a stable sulfinyl radical, most likely located on C263. The unusual radical stability may be explained by the hydrophobic surroundings of C263, which resemble the hydrophobic pocket surrounding Y177 in native protein R2. The observation of a sulfinyl radical in RNR strengthens the relationship between RNR and another free radical enzyme, pyruvate formate-lyase, where a similar relatively stable sulfinyl radical has been observed in a mutant. Sulfinyl radicals may possibly be considered as stabilized forms of very short-lived thiyl radicals, proposed to be important intermediates in the radical chemistry of RNR.

  • 1288.
    Adrell, Pär
    et al.
    Stockholm University, Faculty of Social Sciences, School of Business.
    Lindhoff, Mårten
    Stockholm University, Faculty of Social Sciences, School of Business.
    Målkonflikter i myndigheters styrning: En studie av Natuvårdsverket2003Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Uppsatsen behandlar målkonflikter i statliga myndigheter som uppstår när krav ställs från en mängd intressen inom och utanför organisationen. Syftet med uppsatsen är att beskriva och öka förståelsen för målkonflikter i den interna styrningen hos Naturvårdsverket. Därtill beskrivs även effektivitetsproblem som uppstår i styrningen när organisationen hanterar målkonflikter.

  • 1289.
    Adrian, Frida
    et al.
    Stockholm University, Faculty of Social Sciences, School of Business.
    Edlund, Janica
    Stockholm University, Faculty of Social Sciences, School of Business.
    Hamnar årsredovisningen i papperskorgen?: En studie av årsredovisningens användbarhet för privata aktieägare i Hennes & Mauritz2001Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Det huvudsakliga syftet med uppsatsen är att kartlägga hur användbar årsredovisningen är som beslutsunderlag för privata aktieägare. Som delsyften belyser vi aktieägarnas uppfattning om deras förståelse eller eventuella brist på förståelse för denna informationskälla, samt vilka önskemål de har vad gäller årsredovisningen utformning och innehåll.

  • 1290.
    Adrian, Frida
    et al.
    Stockholm University, Faculty of Social Sciences, School of Business.
    Edlund, Janica
    Stockholm University, Faculty of Social Sciences, School of Business.
    Vad läser analytikerna?: En studie av årsredovisningens användbarhet för analytiker2002Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Det problem som uppsatsen behandlar är det potentiella ”expectations gap” som existerar mellan den information som företag ger ut i form av årsredovisningen och den information som analytiker efterfrågar. Uppsatsens syfte är att beskriva i vilken utsträckning aktiva medlemmar i Sveriges Finansanalytikers Förening använder sig av informationen i årsredovisningar i sitt arbete.

  • 1291.
    Adrian Meredith, Jenny
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-12009Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis describes the synthesis of molecules designed for inhibition of two aspartic proteases, viral HIV-1 PR and human BACE-1. It also reports on the structure activity relationships of the targeted enzyme inhibitors.

    It is estimated that currently 33 million people are infected with HIV, the causative agent of AIDS. The virus targets T-lymphocytes and macrophages of the human immune system. The HIV-1 PR plays an important role in the viral replication, and by inhibiting the enzyme the disease progression can be slowed down or even halted.

    Herein is reported the design and synthesis of a series of HIV-1 PR inhibitors with novel P2 substituents of which several inhibit the enzyme in the nanomolar range. The aim of the second work was to further develop the inhibitors by the introduction of fluorine. Several attempts were performed to fluorinate different P2-substituents.

    Alzheimer’s disease (AD) is neurodegenerative, progressive and fatal disorder of the brain. It is associated with accumulation of plaques and tangles that cause impairment and functional decline of brain tissue which result in loss of memory and cognition. The plaques are mainly constituted of amyloid-β peptides that are generated in two steps from the amyloid precursor protein (APP). The cleavage sequence is initiated by the aspartic protease BACE-1, which makes the enzyme a key target in the effort of finding a therapy that aim to slow down the progression of AD.

    Herein are enclosed the development of two series of potent BACE-1 inhibitors. In the first work a synthetic strategy was developed to truncate a previously reported hydroxyethylene core structure in order to generate more drug-like inhibitors. This generated a series of truncated inhibitors where two amide bonds have been replaced with an ether - or alternatively a secondary amine linkage. A number of these inhibitors show potency against BACE-1. In the second part of the work the aim was investigate the effect of alterations in the P1 position. Five scaffolds with new P1 substituents were designed, synthesized and coupled with two different P2-P3 substituents. This resulted in a series of potent inhibitors that inhibit BACE-1 in the nanomolar range.

  • 1292.
    Adrian Meredith, Jenny
    et al.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Björklund, Catarina
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Adolfsson, Hans
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Edlund, Michael
    Jansson, Katarina
    Lindberg, Jimmy
    Vrang, Lotta
    Hallberg, Anders
    Institutionen för läkemedelskemi, Uppsala universitet.
    Rosenquist, Åsa
    Samuelsson, Bertil
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Design and Synthesis of BACE-1 Inhibitors Containing a New Hydroxyethylene (HE) Scaffold: Potent activities in a cellular assayManuscript (preprint) (Other academic)
    Abstract [en]

    In a preceding report from our group we disclosed the development of a novel HE transition state isostere with a difluorophenoxymethyl side chain in the P1 position and a methoxy group in the P1’ position furnishing highly potent inhibitors of BACE-1 (i.e. lead compound 1), which moreover exhibit very promising selectivity over cathepsin D. In a continuation of this work with the aim at improving on the cell-based activity and pharmacokinetic properties, we have further developed the SAR for the P1 side chain of inhibitor 1 whereby the P1 side chain oxygen has been substituted for an amine, a carbon or a bond. The chemistry developed for the previous HE inhibitor structure 1 has now been extended to readily accommodate the introduction of new P1 side chains into this new HE scaffold. These modifications have given rise to several highly potent inhibitors where the most potent displayed a BACE-1 Ki value of 0.2 nM and a cell-based Aβ40 IC50 value of 9 nM. Thus, regarding the enzyme inhibition in the cell assay a more than 600-fold improvement compared to compound 1 was achieved via minor structural alterations.

  • 1293.
    Adrian Meredith, Jenny
    et al.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Björklund, Catarina
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Adolfsson, Hans
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Jansson, Katarina
    Hallberg, Anders
    Institutionen för läkemedelskemi, Uppsala universitet.
    Rosenquist, Åsa
    Samuelsson, Bertil
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    P2’-truncated BACE-1 inhibitors with a novel hydroxethylene-like core2010In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 45, no 2, p. 542-554Article in journal (Refereed)
    Abstract [en]

    Highly potent BACE-1 protease inhibitors derived from a novel hydroxyethylene-like core structure were recently developed by our group using X-ray crystal structure data and molecular modelling. In a continuation of this work guided by molecular modelling we have explored a truncated core motif where the P2’ amide group is replaced by an ether linkage resulting in a set of alkoxy, aryloxy and alkylaryl groups, with the overall aim to reduce molecular weight and the number of amide bonds to increase permeability and bestow the inhibitors with drug-like features. The most potent of these inhibitors displayed a BACE-1 IC50 value of 140 nM. The synthesis of these BACE-1 inhibitors utilizes readily available starting materials, furnishing the target compounds in good overall yields.

  • 1294.
    Adrian Meredith, Jenny
    et al.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Wallberg, Hans
    Vrang, Lotta
    Oscarson, Stefan
    Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
    Parkes, Kevin
    Hallberg, Anders
    Institutionen för läkemedelskemi, Uppsala universitet.
    Samuelsson, Bertil
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Design and Synthesis of Novel P2 Substituents in Diol-based HIV Protease Inhibitors2010In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 45, no 1, p. 160-170Article in journal (Refereed)
    Abstract [en]

    The synthesis and SAR of HIV-1 protease inhibitors containing novel P2 structural elements are presented. The inhibitors were designed having hydrogen bond accepting P2 substituents to probe potential favorable interactions to Asp-29/Asp-30 of the HIV-1 protease backbone utilizing inhibitor 3 as a model template. Several inhibitors were synthesized from an L-Val-methylamide P2 motif by appending hydrogen bonding moieties from either the isopropyl side chain or from the methylamide portion. The most promising inhibitors 4a and 4e displayed Ki values of 1.0 nM and 0.7 nM respectively and EC50 values in the MT4 cell-based assay of 0.17 µM and 0.33 µM respectively, a slight loss in potency compared to lead inhibitor 3. These inhibitors were also tested against an HIV protease inhibitor resistant strain carrying the M46I, V82F, and I84V mutations. Inhibitors 4a and 4e displayed a 3 and 4 fold change respectively compared with HIV wild type, whereas lead inhibitor 3 showed a higher 9 fold change. This study further demonstrate the chemical tractability of the approach where various P2 substituents can be introduced in just one chemical step from lactone x enabling facile modifications of the overall properties in this inhibitor class.

  • 1295.
    Adrian, Ninnie
    et al.
    Stockholm University, Faculty of Social Sciences, School of Business.
    Paulsson, Sofie
    Stockholm University, Faculty of Social Sciences, School of Business.
    I krisens spår: Hur organisationer kan vända kris till kompetens2008Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background and rationale: In the world we live in today the question is no longer ’if’ an organization will face a crisis, but ’when’ and ’how prepared’ is the organization to deal with it. The Tsunami that happened on December 26th 2004 was a disaster of unprecedented magnitude. It had an impact on the Swedish society in general and the travel industry in particular. As the travel industry is very susceptible to impacts by external factor, its participants can never be too prepared to face a crisis. In order to be better prepared for future crisis, organizations should seek to learn from their experiences.

    The research question for this dissertation is: How can tour-operators improve their organizational competence by using experiences from a crisis?

    The aim of the dissertation is:

    • To map the tour-operators’ crisis management work, and which parts of this work has changed as a result of the Tsunami.
    • To identify and compare the differences in the lessons learned by the tour-operators from the Tsunami.
    • To discuss and give recommendations on how experiences from crises can be used and lead to change, i.e. in better crisis management routines and higher organizational competence

    Methodology: We have used a qualitative research method in our dissertation, our approach is deductive and for the gathering of empirical data, we have made semi-structured interviews. Our research model has been the base for the interviews. Our model shows how the different phases of a crisis – before, during and after – influence organizational competence. The selected companies for our research are the tour-operators Ving and Fritidsresor.

    In our field study we map how the crisis management of the tour-operators is functioning today, and which parts of this work has changed as a result of the Tsunami. In our analysis we see that the tour-operators crisis management work in large parts coincides with the theories in the area, but there are differences in the learning processes of the organizations.

    Results and conclusions drawn from our research are that the learning processes of the tour-operators already start during the crisis. By addressing the deficiencies observed during the Tsunami, new routines, systems and work processes have improved their preparedness for crisis. Both organizations have learned, but the focus at Ving has been on structural capital and at Fritidsresor on human capital. Both have introduced crisis rehearsals, but not throughout the whole organization. Whether the organizational competence to handle a big crisis has improved will be seen as the next large crisis occurs.

    .

     

  • 1296. Adriani, O.
    et al.
    Barbarino, G. C.
    Bazilevskaya, G. A.
    Bellotti, R.
    Boezio, M.
    Bogomolov, E. A.
    Bongi, M.
    Bonvicini, V.
    Borisov, S.
    Bottai, S.
    Bruno, A.
    Cafagna, F.
    Campana, D.
    Carbone, R.
    Carlson, P.
    Stockholm University, Faculty of Science, The Oskar Klein Centre for Cosmo Particle Physics (OKC).
    Casolino, M.
    Castellini, G.
    Consiglio, L.
    De Pascale, M. P.
    De Santis, C.
    De Simone, N.
    Di Felice, V.
    Galper, A. M.
    Gillard, W.
    Stockholm University, Faculty of Science, The Oskar Klein Centre for Cosmo Particle Physics (OKC).
    Grishantseva, L.
    Jerse, G.
    Karelin, A. V.
    Koldashov, S. V.
    Krutkov, S. Y.
    Kvashnin, A. N.
    Leonov, A.
    Malakhov, V.
    Malvezzi, V.
    Marcelli, L.
    Mayorov, A. G.
    Menn, W.
    Mikhailov, V. V.
    Mocchiutti, E.
    Monaco, A.
    Mori, N.
    Nikonov, N.
    Osteria, G.
    Palma, F.
    Papini, P.
    Pearce, M.
    Stockholm University, Faculty of Science, The Oskar Klein Centre for Cosmo Particle Physics (OKC).
    Picozza, P.
    Pizzolotto, C.
    Ricci, M.
    Ricciarini, S. B.
    Rossetto, L.
    Stockholm University, Faculty of Science, The Oskar Klein Centre for Cosmo Particle Physics (OKC).
    Sarkar, R.
    Simon, M.
    Sparvoli, R.
    Spillantini, P.
    Stochaj, S. J.
    Stockton, J. C.
    Stozhkov, Y. I.
    Vacchi, A.
    Vannuccini, E.
    Vasilyev, G.
    Voronov, S. A.
    Wu, J.
    Stockholm University, Faculty of Science, The Oskar Klein Centre for Cosmo Particle Physics (OKC).
    Yurkin, Y. T.
    Zampa, G.
    Zampa, N.
    Zverev, V. G.
    Cosmic-Ray Electron Flux Measured by the PAMELA Experiment between 1 and 625 GeV2011In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 106, no 20, p. 201101-Article in journal (Refereed)
    Abstract [en]

    Precision measurements of the electron component in the cosmic radiation provide important information about the origin and propagation of cosmic rays in the Galaxy. Here we present new results regarding negatively charged electrons between 1 and 625 GeV performed by the satellite-borne experiment PAMELA. This is the first time that cosmic-ray e(-) have been identified above 50 GeV. The electron spectrum can be described with a single power-law energy dependence with spectral index -3.18 +/- 0.05 above the energy region influenced by the solar wind (> 30 GeV). No significant spectral features are observed and the data can be interpreted in terms of conventional diffusive propagation models. However, the data are also consistent with models including new cosmic-ray sources that could explain the rise in the positron fraction.

  • 1297.
    Adriansson, Linus
    Stockholm University, Faculty of Science, Department of Physical Geography.
    Stockholm i färger: En kritisk diskursanalys av kulturarvets produktion och legitimering i stadens bebyggelsemiljö2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Avsikten med denna uppsats är att med en kritisk diskursanalys undersöka hur kunskap om kulturarvet och kulturhistoriska värden konstrueras i Stockholms byggda miljö. Akademisk litteratur inom kulturarvsforskningen beskriver en situation där det uppstått ett glapp mellan teori och praktik inom kulturarvssektorn som vidgats sedan postmodernismens och konstruktionismens framväxt i början på 1970-talet. Den utövande kulturarvsvården och värderingsprocessen är i stor utsträckning styrd av värdeorienterade klassificeringssystem där utgångspunkten är att finna och tolka olika värdetyper i ett objekt. Detta traditionella förhållningssätt är en del av ”den auktoriserade kulturarvsdiskursen”; ett begrepp inom kulturarvsforskningen som menar att kulturarvssektorn premierar traditionella värden genom expertutpekanden vilket leder till en reproduktion av kanoniserade objekt med vissa ideologiska förtecken. Sedan år 1974 finns det i Sverige nationella kulturpolitiska mål fastslagna och sedan år 2012 finns det fyra nationella kulturmiljömål som landets kulturmiljövårdande institutioner ska sträva. Målens tankegods förmedlar en ambition om att göra kulturmiljöer och kunskap tillgängligt för att främja demokratisering av kulturarvet. I Stockholms kommun är det Stadsmuseet som ansvarar för utpekandet och klassificeringen av kulturhistoriskt värdefulla byggnader och miljöer. Syftet med undersökningen är att bidra med en djupare förståelse för hur kunskapen om kulturhistoriska värden i Stockholms byggda kulturmiljö produceras och legitimeras. Resultat och analys visar att diskurserna i Stadsmuseets översiktsdokument sedan klassificeringens introduktion under tidigt 1980-tal har förändrats av ideologiska, politiska och ekonomiska element. Museets och kommunens samtida översiktsdokument har en anknytning till kunskapsläget inom kulturarvsforskningen genom att argumentera för relativa, pluralistiska värden. Men den traditionella värdesynen och expertdiskursen i värderingsprocessen har lett till en värdering och klassificering som reproducerar en traditionell förståelse av det byggda kulturarvet. En universell metod i kombination med intern praxis används för att identifiera vilka kulturhistoriska värden som finns, utan att precisera vilka egenskaper som upprätthåller dessa värden. Det ger klassificeringen en svag anknytning till kulturarvsforskning, regeringens kulturpolitiska mål och den egna institutionens värdesyn i samtida översiktsdokument.

  • 1298.
    Adscheid, Toni
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    When Ecotopia grows: Politicizing the stories of Swedish sustainable urban development2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Sweden is known world-wide for its achievements in the field of sustainable urban development. Due to this global recognition Swedish stories and policies of sustainable urban development are being spread across various spatial and institutional contexts. Focusing on SymbioCity and its approach as examples for such stories, this thesis seeks to elaborate on the de-politicization of urban environments through sustainable urban development policies. In doing so, this thesis synthesises urban political ecology and policy mobility literature to form a theoretical framework to investigate the mobilization and legitimization of such environments. Drawing on findings provided by methods of text analysis and interviews, it is illustrated that Swedish stories of sustainable urban development construct a de-politicized spatiality supported by capital, desires of influence and “the planner”. The thesis concludes by arguing that planning research needs to critically address the process of de-politicization and support the articulation of a political Ecotopia. 

  • 1299. Adscheid, Toni
    et al.
    Schmitt, Peter
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Constructing the sustainable city: Policy mobilities of Swedish sustainable urban development2018In: Globala flöden och lokala praktiker: policymobilitet i tid och rum / [ed] Ida Andersson, Svenska sällskapet för antropologi och geografi , 2018, p. 225-245Chapter in book (Other academic)
  • 1300. Adscheid, Toni
    et al.
    Schmitt, Peter
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Mobilising post-political environments: tracing the selective geographies of Swedish sustainable urban development2019In: Urban Research and Practice, ISSN 1753-5069, E-ISSN 1753-5077Article in journal (Refereed)
    Abstract [en]

    This paper develops an analytical framework from which to understand the mobilisation of post-political urban environments across spatial and institutional contexts. Our analysis of two closely related cases from a Swedish context reveals the potential benefits of combining studies on urban political ecology and policy mobility. By utilising Actor-Network Theory (ANT) we illustrate how post-political environments that are shaped by mobile and mutating policies of sustainable urban development are stabilised through distinct discursive strategies, capital investments and the desire for increased influence within global frames of action and contribute to the creation of, what we call, selective geographies.

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