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  • 151.
    Bahati, Bernard
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap. University of Rwanda, Rwanda.
    Fors, Uno
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Tedre, Matti
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Can Student Engagement in Online Courses Predict Performance on Online Knowledge Surveys?2017Inngår i: International Journal of Learning, Teaching and Educational Research, ISSN 1694-2493, E-ISSN 1694-2116, Vol. 16, nr 3, s. 73-87Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The link between student engagement and academic performance has been widely examined. However, most of these studies have focused on ascertaining the existence of such a relationship on the summative assessment level. By comparing students’ experience points in an online course and students’ scores on online knowledge surveys (KS), this study examined the relationship between student engagement and performance on online KS on the formative assessment level. Knowledge surveys were developed and formatively administered in four sections of an online Integration of ICT in Education course. Using Moodle Feedback Module, knowledge surveys were designed based on three key elements: learning objectives, the course content, and the revised Bloom’s Taxonomy of learning objectives. Using rated multiple choice KS questions, the correlation between students’ scores on KSs and students’ experience points was calculated using SPSS. The results show that students’ confidence levels in ability to answer KS questions increased in some of the course sections and decreased in others.  The student engagement in online course was positively—but weakly—related to student performance on online KS and the strength of this relationship increased as the course unfolded. Our conclusion is that student engagement in online courses would not be an accurate predictor of student performance on online Knowledge surveys right at the beginning of an instructional process.

  • 152.
    Bahati, Bernard
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Tedre, Matti
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Fors, Uno
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Evode, Mukama
    Exploring feedback practices in formative assessment in Rwandan higher education: a multifaceted approach is needed2016Inngår i: International Journal of Teaching and Education, ISSN 1993-3916, Vol. IV, nr 2, s. 1-22Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Inspired by the current scholarship that indicates that, if used well, formative assessment and feedback can advance student’s learning, this paper explores the practices of feedback in formative assessment in Rwandan higher education, specifically at the University of Rwanda. The study used aqualitative approach with the aim of gaining lecturers’ and students’ perspectives on formative assessment and feedback; and exploring different ways formative assessment and feedback were practiced. Using data collected through interviews, student focus group discussions, and document analysis; the paper shows that formative assessment and feedback were understood in the context of binding prescription within the boundaries of limited description in academic regulations. Feedback was in most cases reduced to marks, and lecturers – who portrayed themselves as information providers, mastery checkers, and performance appraisers - were in full charge of all formative assessment efforts. The paper also shows that lack of clarity and feed forward instructionsin too-much-delayed lecturers’ written feedback led students to just receive feedback and not use it to enhance their performance. Building on this study’s findings and on the existing literature, the paper suggests three important moves whereby a collaborative research-based approach that will bring together different stakeholders will help to move away from a single-sided approach to a multifaceted approach in both perception and practice of formative assessment and feedback at the University of Rwanda.

  • 153.
    Bakari, Jabiri Kuwe
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    A Holistic Approach for Managing ICT Security in Non-Commercial Organisations: A Case Study in a Developing Country2007Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The research reported here is about improvement of the ICT security management process in non-commercial organisations in order to reduce possible financial damage, taking into consideration the realities found in developing countries. The research took place in a developing country—Tanzania, where five organisations were involved.

    The study is organised into seven papers covering: the state of ICT security management in the organisations; prerequisites when utilising the existing ICT security management approaches in attaining a solution for managing ICT security in the organisations; issues and challenges of managing ICT security; important aspects to be taken into consideration in order to successfully manage ICT security; and how the management of ICT security in non-commercial organisations could be improved. Among others, the research was motivated by the observed need for bridging the perception gap between the management and technicians when dealing with the ICT security problem, and consequently extending to a common understanding by the staff in the various departments and specialities within and between the departments.

    The thesis contributes to increased empirical knowledge on the importance of the holistic ICT security management process. Particularly, our main contribution is the proposed holistic approach for managing ICT security in non-commercial organisations, organised in the form of guidelines with two main phases: the initialisation phase which involved the introduction of the ICT security management process in the organisation; and the internalised and continuous phase.

  • 154. Balke, Tina
    et al.
    Cranefield, Stephen
    Di Tosto, Gennaro
    Mahmoud, Samhar
    Paolucci, Mario
    Savarimuthu, Bastin Tony Roy
    Verhagen, Harko
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Simulation and NorMAS2013Inngår i: Normative Multi-Agent Systems, Dagstuhl: Schloss Dagstuhl--Leibniz-Zentrum fuer Informatik , 2013, Vol. 4, s. 171-189Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    In this chapter, we discuss state of the art and future perspective of the study of norms with simulative methodologies, in particular employing agent-based simulation. After presenting the state of the art and framing the simulative research on norms in a norm life-cycle schema, we list those research challenges that we feel more apt to be tackled by the simulative approach. We conclude the chapter with the indications for the realization of a NorMAS simulation platform, illustrated by selected scenarios. 

  • 155. Balke, Tina
    et al.
    Mahmood, Samhar
    Neumann, Martin
    Verhagen, Harko
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Analysing the Electrical Patient Recruiting Agent System using the WIT trinity2014Inngår i: Proceedings of the European Conference on Social Intelligence (ECSI-2014), 2014, s. 329-335Konferansepaper (Fagfellevurdert)
  • 156.
    Barabanov, Rostyslav
    et al.
    Stockholm University, Social Sciences, DSV.
    Kowalski, Stewart
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Yngström, Louise
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Information Security Metrics: State of the Art: State of the art2011Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Rapporten är en sammanställning och analys av forskning inom säkerhetsmetriker

  • 157.
    Barkhuus, Louise
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Television on the Internet: New Practices, New Viewers2009Inngår i: International Conference on Human Factors in Computing Systems, ACM , 2009Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Television is increasingly viewed through computers in the form of downloaded or steamed content, yet computer based television consumption has received little attention in HCI. In this paper we describe a study of the uses and practices of tech-savvy college students, studying their television consumption through the internet. We find that users personalize their viewing but that TV is still a richly social experience - not as communal watching, but instead through communication around television programs. We explore new possibilities for technology-based interaction around television.

  • 158.
    Barkhuus, Louise
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    The Mismeasurement of Privacy: Using Contextual Integrity to Reconsider Privacy in HCI2012Inngår i: CHI '12: Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, New York: Association for Computing Machinery (ACM), 2012, s. 367-376Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Privacy is a widely studied concept in relation to social computing and sensor-based technologies; scores of research papers have investigated people’s ‘privacy preferences’ and apparent reluctance to share personal data. In this paper we explore how Ubicomp and HCI studies have approached the notion of privacy, often as a quantifiable concept. Leaning on several theoretical frameworks, but in particular Nissenbaum’s notion of contextual integrity, we question the viability of obtaining universal answers in terms of people’s ‘general’ privacy practices and apply elements of Nissenbaum’s theory to our own data in order to illustrate its relevance. We then suggest restructuring inquiries into information sharing in studies of state-of-the-art technologies and analyze contextually grounded issues using a different, more specific vocabulary. Finally, we provide the first building blocks to such vocabulary.

  • 159.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Brown, Barry
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    The Sociality of Fieldwork: Designing for Social Science Research Practice and Collaboration2012Inngår i: PROCEEDINGS OF THE 17TH ACM INTERNATIONAL CONFERENCE ON SUPPORTING GROUP WORK, Association for Computing Machinery (ACM), 2012, s. 35-44Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Supporting scientific practice has been a longstanding goal of CSCW research. This paper explores how we might design for social science research practices and collaboration. Drawing on sixteen interviews with fieldwork-based social scientists we document the importance of small-scale long-term collaborative arrangements for research and intellectual work - pairs of researchers who work together in-depth over their careers, developing a common yet distinctive view of their research field. This contrasts with the large-scale short-lived collaborations that have classically been the target of cyber-infrastructure work. We describe technology practices among social scientists and how these can inform technology design for fieldwork practices.

  • 160.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Brown, Barry
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Unpacking the television: User practices around a changing technology2009Inngår i: Transactions n Computer-Human Interaction, Vol. 16Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article investigates the changing television watching practices amongst early adopters of personal hard-disk video recorders (such as Tivo) and Internet downloading of video. Through in- depth interviews with 21 video enthusiasts, we describe how the rhythms of television watching change when decoupled from broadcast TV schedules. Devices such as Tivo do not simply replace videotapes; TV watching becomes more active as programs are gathered from the schedules, played from a stored collection and fast forwarded and paused during playback. Downloads users exploit the Internet to view shows and movies not broadcast, yet this watching is not fundamentally different from recording shows using a PVR, since both involve selection of shows from a limited range and a wait before the shows can be watched.

  • 161.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Brown, Barry
    Mobile Life Centre @ Stockholm University, , .
    Bell, Marek
    University of Glasgow, , .
    Sherwood, Scott
    University of Glasgow, , .
    Hall, Malcolm
    University of Glasgow, , .
    Chalmers, Matthew
    University of Glasgow, , .
    Awareness and Repartee: Sharing location on the go2008Inngår i: International Conference on Human Factors in Computing Systems, ACM , 2008Konferansepaper (Fagfellevurdert)
  • 162.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Cowan, Lisa
    University of California, San Diego, , .
    Griswold, William
    University of California, San Diego, , .
    Hollan, James
    University of California, San Diego, , .
    Engaging the Periphery for Visual Communication on Mobile Phones2010Inngår i: Hawaii International Conference on System Sciences, IEEE , 2010Konferansepaper (Fagfellevurdert)
    Abstract [en]

    While mobile phones have become ubiquitous instruments of communication and social interaction, they still require explicit interaction, placing high demands on attention. Engaging the periphery of users’ attention offers opportunities for awareness and interaction while reducing demands on attention and risks of disruption. We explore the mobile peripheral design space with Emotipix, an application for camera phones that turns the background of the phone’s display into a place for visual conversations. We conducted an exploratory 2-week user study with 6 pairs and one 4- person group, and found that Emotipix facilitated ongoing social practices. Our study shows that there is an unexploited opportunity to use mobile phones for peripheral awareness. We provide recommendations for managing users’ expectations, desires for control, and privacy in mobile peripheral display design.

  • 163.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Engström, Arvid
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Zoric, Goranka
    Watching the footwork: second screen interaction at a dance and music performance2014Inngår i: Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, New York: Association for Computing Machinery (ACM), 2014, s. 1305-1314Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Interactive mobile technologies have become part of audience experiences of live performances in terms of both general media sharing and specific (sometimes official) extra content. At the same time, high bandwidth affords streaming of live events to mobile devices. We take advantage of these technologies in our high resolution, panoramic image video stream and study a scenario of audience members viewing the very same live event they are watching on a tablet. The video stream on the tablet is navigational and enables audience members to pan and zoom in the real-time video feed. We studied audience interaction and impressions in three performances of a dance and music show and found distinct uses of the second screen video stream. We emphasize that despite initial reluctance, the observed utilization of the technology opened up for new potential practices. Our study shows how working with perceived conflict in technology can still open up design space for interactive technologies.

  • 164.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Jorgensen, Tobias
    Copenhagen University, , .
    Engaging the Crowd at Large Musical Events2008Inngår i: International Conference on Human Factors in Computing Systems, 2008Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In this work-in-progress we explore audience behavior at large musical events and present our prototype, a ‘cheering meter’ developed to aid voting at rap competitions. We report from use of the cheering meter at eight concerts and conclude by highlighting how augmented interaction can increase the sense of participation among the audience at large-scale performances.

  • 165.
    Barkhuus, Louise
    et al.
    University of California, USA.
    Lecusay, Robert
    University of California, USA.
    Social Infrastructures as Barriers and Foundation for Informal Learning: Technology Integration in an Urban After-School Center2012Inngår i: Computer Supported Cooperative Work, ISSN 0925-9724, E-ISSN 1573-7551, Vol. 21, nr 1, s. 81-103Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this paper we explore the relationship between social learning environments and the technological ecologies that practitioners, learners, and researchers develop to sustain them. Through an examination of ethnographic research conducted at an urban after- school learning program we show how social, technological and power infrastructures influence learning and interaction in this setting. Adopting a holistic approach we examine how technologies are integrated into activities in this program to support the learning of the after-school youth. We emphasize both positive and negative infrastructures that contribute to the learning environment and discuss how identifying these infrastructures are one of the first steps towards understanding and informing technology design in informal learning settings.

  • 166.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Polichar, Valerie
    Empowerment through seamfulness: Smart phones in everyday life2010Inngår i: Personal and Ubiquitous Computing, Vol. 15Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this paper, we describe research into use of multifunctional mobile phones by working adults and posit the device as a plausible realization of ubiquitous com- puting. We investigate how users actively adapt and adopt the different functions in smart phones to suit their needs and lifestyles. Through an interview and diary study, we discover how the smart phone is used in pragmatic and seamful ways, regardless of the interface of the specific phone selected or the particular features available. Users used phones in highly individual manners; mixed and adapted existing functions to meet their own priorities; added some functions and ignored others to create their own portfolio; and blended their use with the specifics of their everyday lives. While these data challenge some assumptions of human–computer interaction and ubiqui- tous computing, it also presents new research potential in terms of understanding how users take advantage of the multiple features in smart phone devices and how they utilize seamfulness in everyday smart phones practices.

  • 167.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Rossitto, Chiara
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Acting with Technology: Rehearsing for Mixed-Media Live Performances2016Inngår i: CHI '16 Proceedings of the 2016 CHI Conference on Human Factors in Computing Systems, Association for Computing Machinery (ACM), 2016, s. 864-875Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Digital technologies provide theater with new possibilities for combining traditional stage-based performances with interactive artifacts, for streaming remote parallel performances and for other device facilitated audience interaction. Compared to traditional theater, mixed-media performances require a different type of engagement from the actors and rehearsing is challenging, as it can be impossible to rehearse with all the functional technology and interaction. Here, we report experiences from a case study of two mixed-media performances; we studied the rehearsal practices of two actors who were performing in two different plays. We describe how the actors practiced presence during rehearsal in a play where they would be geographically remote, and we describe the challenges of rehearsing with several remote and interactive elements. Our study informs the broader aims of interactive and mixed media performances through addressing critical factors of implementing technology into rehearsal practices.

  • 168.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Rossitto, Chiara
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Ekenberg, Love
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Forsberg, Rebecca
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Sauter, Willmar
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Interactive Performances as a Means of Social Participation and Democratic Dialogue2014Inngår i: International Reports on Socio-Informatics (IRSI), ISSN 1861-4280, E-ISSN 1861-4280, Vol. 11, nr 1, s. 11-20Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this position paper we present our ongoing research in relation to cultivating democracy and civic participation through the writing and performance of interactive theater experiences1. We provide an example of a performance that facilitates audience participation through expression and sharing of opinions and emotions, by means of digital technologies. The performance leads to further discussion within the community and inspires more artistic and theatrical experiences in this context.

  • 169.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Tashiro, Juliana
    University of California, San Diego, , .
    Social networking on the go: Students' socialization in the age of Facebook2010Inngår i: International conference on Human factors in computing systems (CHI), ACM , 2010Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Most research regarding online social networks such as Facebook, MySpace, Linked-In and Friendster has looked at these networks in terms of activity within the online network, such as profile management and friending behavior. In this paper we are instead focusing on offline socializing structures around an online social network (exemplified by Facebook) and how this can facilitate in- person social life for students. Because students lead nomadic lives, they find Facebook a particularly useful tool for initiating and managing social gatherings, and as they adopt mobile technologies that can access online social networks, their ad-hoc social life is further enabled. We conclude that online social networks are a powerful tool for encouraging peripheral friendships, important in particular to students. We emphasize that the use of online social networks must be viewed from a perspective of use that involves both mobile and stationary platforms and that it is important to relate online and offline social practices.

  • 170.
    Barkhuus, Louise
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Zoric, Goranka
    Engström, Arvid
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Ruiz-Hidalgo, Javier
    Verzijp, Nico
    New interaction modes for rich panoramic live video experiences2014Inngår i: Behavior and Information Technology, ISSN 0144-929X, E-ISSN 1362-3001, Vol. 33, nr 8, s. 859-869Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The possibilities of panoramic video are based on the capabilities of high-resolution digital video streams and higher bandwidth's opportunities to broadcast, stream and transfer large content across platforms. With these opportunities also come challenges such as how to focus on sub-parts of the video stream and interact with the content shown on a large screen. In this paper, we present studies of two different interaction modes with a large-scale panoramic video for live experiences; we focus on interactional challenges and explore if it is (1) possible to develop new interactional methods/ways of approaching this type of high-resolution content and (2) feasible for users to interact with the content in these new ways. We developed prototypes for two different interaction modes: an individual system on a mobile device, either a tablet or a mobile phone, for interacting with the content on the same and a non-touch gesture-based system for the home or small group interaction. We present pilot studies where we explore the possibilities and challenges with these two interaction modes for panoramic content.

  • 171. Barot, Camille
    et al.
    Buro, Michael
    Cook, Michael
    Eladhari, Mirjam
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Johansson, Magnus
    Li, Boyang
    Liapis, Antonios
    McCoy, Josh
    Ontanon, Santiago
    Rowe, Jonathan
    Tomai, Emmett
    Verhagen, Harko
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Zook, Alexander
    The AIIDE 2015 Workshop Program2016Inngår i: The AI Magazine, ISSN 0738-4602, Vol. 37, nr 2, s. 91-94Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The workshop program at the 11th Annual AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment was held November 14-15, 2015, at the University of California, Santa Cruz, USA. The program included four workshops (one of which was a joint workshop): Artificial Intelligence in Adversarial Real-Time Games, Experimental AI in Games, Intelligent Narrative Technologies and Social Believability in Games, and Player Modeling. This article contains the reports of three of the four workshops.

  • 172.
    Basile, Walter
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab).
    Sachenkova, Oxana
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab).
    Light, Sara
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab). Linköping University, Sweden.
    Elofsson, Arne
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab). Kungliga Tekniska Högskolan, Sweden.
    High GC content causes orphan proteins to be intrinsically disordered2017Inngår i: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 13, nr 3, artikkel-id e1005375Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    De novo creation of protein coding genes involves the formation of short ORFs from noncoding regions; some of these ORFs might then become fixed in the population These orphan proteins need to, at the bare minimum, not cause serious harm to the organism, meaning that they should for instance not aggregate. Therefore, although the creation of short ORFs could be truly random, the fixation should be subjected to some selective pressure. The selective forces acting on orphan proteins have been elusive, and contradictory results have been reported. In Drosophila young proteins are more disordered than ancient ones, while the opposite trend is present in yeast. To the best of our knowledge no valid explanation for this difference has been proposed. To solve this riddle we studied structural properties and age of proteins in 187 eukaryotic organisms. We find that, with the exception of length, there are only small differences in the properties between proteins of different ages. However, when we take the GC content into account we noted that it could explain the opposite trends observed for orphans in yeast (low GC) and Drosophila (high GC). GC content is correlated with codons coding for disorder promoting amino acids. This leads us to propose that intrinsic disorder is not a strong determining factor for fixation of orphan proteins. Instead these proteins largely resemble random proteins given a particular GC level. During evolution the properties of a protein change faster than the GC level causing the relationship between disorder and GC to gradually weaken.

  • 173.
    Bathallath, Sameer
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Smedberg, Åsa
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Kjellin, Harald
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Impediments to Effective Management of Project Interdependencies: A Study of IT/IS Project Portfolios2017Inngår i: Journal of Electronic Commerce in Organizations, ISSN 1539-2937, E-ISSN 1539-2929, Vol. 15, nr 2, s. 16-30Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Interdependencies between projects have come to play a more active role in the decision on IT/IS portfolios and their constituent projects. However, managing these interdependencies can be a complex task, especially when the number and degree of interdependencies among projects are high. In times of uncertainty, unexpected challenges can seriously disrupt projects and, consequently, their interdependencies. This may threaten the project portfolio from achieving its final goal. The study aims to investigate the difficulties associated with managing project interdependence along the development cycle of the project portfolio. The study was conducted using a qualitative approach and semi-structured interviews with managers from four leading organizations in Saudi Arabia. The findings reveal three main categories of factors that increased the difficulty of managing project interdependencies in large IT/IS project portfolios: insufficient understanding of human responsibilities in the whole portfolio, unpredictability of the environment, and technology barriers and constraints.

  • 174.
    Bathallath, Sameer
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Smedberg, Åsa
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Kjellin, Harald
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    INVESTIGATING THE SOURCES OF DIFFICULTIES IN MANAGING PROJECT INTERDEPENDENCIES: A STUDY OF IT/IS PROJECT PORTFOLIOS2016Inngår i: PROCEEDINGS OF THE 9th IADIS INTERNATIONAL CONFERENCE INFORMATION SYSTEMS 2016 / [ed] Miguel Baptista Nunes, Pedro Isaías, Philip Powell, IADIS Press, 2016, s. 71-82Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Interdependencies between projects can take a major role in IT/IS project portfolios. However, managing these interdependencies can be a difficult task, especially when the number and diversity of projects grow large in scale. In times of unexpected events, extra management efforts are inevitable for treating the subsequent effects on the projects and their interdependencies, and for maintaining high-performance portfolios. Complexity is also a concern for managers, and a growing complexity level may threatens the project portfolio from achieving its final goal. This paper investigates the managerial issues and difficulties in handling project interdependencies. For a closer look at these interdependencies and to gain more understanding of the problem area, a qualitative study was conducted based on semi-structured interviews with managers from four leading organizations in different industries in Saudi Arabia. The findings reveal three main sources of difficulty in managing project interdependencies in IT/IS project portfolios: 1) Insufficient understanding of human responsibilities in the whole portfolio, 2) Environmental change and 3) Technological constraints.

  • 175.
    Bathallath, Sameer
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Smedberg, Åsa
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Kjellin, Harald
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Managing project interdependencies in IT/IS project portfolios: a review of managerial issues2016Inngår i: International journal of information systems and project management, ISSN 2182-7796, E-ISSN 2182-7788, Vol. 4, nr 1, s. 67-82Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Adequately managing project interdependencies among diverse and simultaneous projects is deemed critical for successful implementation of project portfolios. The challenge is significant because it may entail managing a complex network of project interdependencies that keeps changing over time. The present study investigates the managerial challenges that may undermine effective management of project interdependencies in IT/IS project portfolios. The investigation is based on evidence from reviewing relevant literature and documented studies associated with managing project interdependencies. The main contribution of this study is to discuss three managerial challenges of project interdependencies in project portfolios. We discuss the challenges from three perspectives: types of interdependencies; patterns of interaction in interdependencies; and cost/benefit impact of project interdependencies.

  • 176.
    Bathallath, Sameer
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Smedberg, Åsa
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Kjellin, Harald
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Managing project interdependencies in IT/IS project portfolios: a review of managerial issues2016Inngår i: International journal of information systems and project management, ISSN 2182-7796, E-ISSN 2182-7788, Vol. 4, nr 1, s. 67-82Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Adequately managing project interdependencies among diverse and simultaneous projects is deemed critical for successful implementation of project portfolios. The challenge is significant because it may entail managing a complex network of project interdependencies that keeps changing over time. The present study investigates the managerial challenges that may undermine effective management of project interdependencies in IT/IS project portfolios. The investigation is based on evidence from reviewing relevant literature and documented studies associated with managing project interdependencies. The main contribution of this study is to discuss three managerial challenges of project interdependencies in project portfolios. We discuss the challenges from three perspectives: types of interdependencies; patterns of interaction in interdependencies; and cost/benefit impact of project interdependencies.

  • 177.
    Bathallath, Sameer
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Smedberg, Åsa
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Kjellin, Harald
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Project interdependency management in IT/IS project portfolios: from a systems perspective2016Inngår i: Procedia Computer Science, ISSN 1877-0509, E-ISSN 1877-0509, Vol. 100, s. 928-934Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Capitalizing on inter-project interdependencies is widely accepted as being crucial for Information Technology/Information Systems (IT/IS) project portfolio success. However, handling these interdependencies becomes a source of increased management complexity as project portfolios get larger, increasingly diverse, and are much influenced by their environments. This then can lead to less predictable situations regarding the portfolio performance as a whole. Though there are many methods available for optimally selecting projects and cross-checking possible synergies and interdependencies among the projects in the portfolio, it remains unclear how one can gain control over the complexity of managing these interdependencies. In this study, we address the problem of handling many project interdependencies that continuously change and develop within a large IT/IS project portfolio. We found that the existing methods for selecting and managing the projects within a portfolio do not focus enough on how interdependencies can disrupt the balance of the whole project portfolio system. To tackle the problem, we propose a systemic approach using the Viable System Model to enhance the way that these interdependencies can be effectively managed in view of the overall portfolio system. We suggest that the Viable System Model, as a supplement to traditional IT/IS project portfolio management approaches, is recursively applied to diagnose and manage the complexity of project interdependencies within IT/IS project portfolios.

  • 178.
    Bell, Linda
    et al.
    TeliaSonera (R and D).
    Boye, Johan
    TeliaSonera (R and D).
    Gustafson, Joakim
    TeliaSonera (R&D).
    Heldner, Mattias
    TeliaSonera (R&D).
    Lindström, Anders
    TeliaSonera (R and D).
    Wirén, Mats
    TeliaSonera (R&D).
    The Swedish NICE Corpus – Spoken dialogues between children and embodied characters in a computer game scenario2005Inngår i: Proceedings Interspeech 2005 - Eurospeech: 9th European Conference on Speech Communication and Technology, Lisbon, Portugal: ISCA , 2005, s. 2765-2768Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This article describes the collection and analysis of a Swedish database of spontaneous and unconstrained children-machine dialogues. The Swedish NICE corpus consists of spoken dialogues between children aged 8 to 15 and embodied fairytale characters in a computer game scenario. Compared to previously collected corpora of children's computer-directed speech, the Swedish NICE corpus contains extended interactions, including three-party conversation, in which the young users used spoken dialogue as the primary means of progression in the game.

  • 179.
    Bell, Linda
    et al.
    TeliaSonera (R & D).
    Boye, Johan
    TeliaSonera (R & D).
    Gustafson, Joakim
    TeliaSonera (R & D).
    Wirén, Mats
    TeliaSonera (R & D).
    Modality Convergence in a Multimodal Dialogue System2000Inngår i: Proceedings of Götalog, 2000, s. 29-34Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    When designing multimodal dialogue systems allowing speech as well as graphical operations, it is important to understand not only how people make use of the different modalities in their utterances, but also how the system might influence a user's choice of modality by its own behavior. This paper describes an experiment in which subjects interacted with two versions of a simulated multimodal dialogue system. One version used predominantly graphical means when referring to specific objects; the other used predominantly verbal referential expressions. The purpose of the study was to find out what effect, if any, the system's referential strategy had on the user's behavior. The results provided limited support for the hypothesis that the system can influence users to adopt another modality for the purpose of referring

  • 180. Benfenati, E.
    et al.
    Golbamaki, A.
    Raitano, G.
    Roncaglioni, A.
    Manganelli, S.
    Lemke, F.
    Norinder, Ulf
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap. Swetox, Sweden.
    Lo Piparo, Elena
    Honma, M.
    Manganaro, A.
    Gini, G.
    A large comparison of integrated SAR/QSAR models of the Ames test for mutagenicity($)2018Inngår i: SAR and QSAR in environmental research (Print), ISSN 1062-936X, E-ISSN 1029-046X, Vol. 29, nr 8, s. 591-611Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Results from the Ames test are the first outcome considered to assess the possible mutagenicity of substances. Many QSAR models and structural alerts are available to predict this endpoint. From a regulatory point of view, the recommendation from international authorities is to consider the predictions of more than one model and to combine results in order to develop conclusions about the mutagenicity risk posed by chemicals. However, the results of those models are often conflicting, and the existing inconsistency in the predictions requires intelligent strategies to integrate them. In our study, we evaluated different strategies for combining results of models for Ames mutagenicity, starting from a set of 10 diverse individual models, each built on a dataset of around 6000 compounds. The novelty of our study is that we collected a much larger set of about 18,000 compounds and used the new data to build a family of integrated models. These integrations used probabilistic approaches, decision theory, machine learning, and voting strategies in the integration scheme. Results are discussed considering balanced or conservative perspectives, regarding the possible uses for different purposes, including screening of large collection of substances for prioritization.

  • 181. Benyon, David
    et al.
    Gambäck, Björn
    Hansen, Preben
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Mival, Oli
    Webb, Nick
    How Was Your Day? Evaluating a Conversational Companion2013Inngår i: IEEE Transactions on Affective Computing, ISSN 1949-3045, E-ISSN 1949-3045, Vol. 4, nr 3, s. 299-311Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The How Was Your Day(HWYD) companion is an embodied conversational agent that can discuss work-related issues, entering free-form dialogues while discussing issues surrounding a typical work day. The open-ended nature of these interactions requires new models of evaluation. Here, we describe a paradigm and methodology for evaluating the main aspects of such functionality in conjunction with overall system behavior, with respect to three parameters: functional ability (i.e., does it do the rightthing conversationally), content (i.e., does it respond appropriately to the semantic context), and emotional behavior (i.e., given the emotional input from the user, does it respond in an emotionally appropriate way). We demonstrate the functionality of our evaluation paradigm as a method for both grading current system performance, and targeting areas for particular performance review. We show correlation between, for example, automatic speech recognition performance and overall system performance (as is expected in systems of this type), but beyond this, we show where individual utterances or responses, indicated as positive or negative, characterize system performance, and demonstrate how our combination evaluation approach highlights issues (both positive and negative) in the companion system's interaction behavior.

  • 182. Benyon, David
    et al.
    Höök, Kristina
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Nigay, Laurence
    Spaces of Interaction2010Inngår i: Proceedings of ACM/BCS Visions of Computer Science, International Academic Research Conference, Edinburgh, ACM/BCS , 2010Konferansepaper (Fagfellevurdert)
  • 183.
    Bergholtz, Maria
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Andersson, Birger
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Johannesson, Paul
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Abstraction, Restriction, and Co-creation: Three Perspectives on Services2010Inngår i: Advances in Conceptual Modeling – Applications and Challenges, Berlin: Springer Verlag , 2010, s. 107-116Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The recent surge in the interest of services has brought a plethora of applications of the service concept. There are business services and software services, software-as-a-service, platform-as-a-service, and infrastructure-as-a-service. There is also a multitude of definitions of the service concept. In this paper, we propose not a new definition of service but a conceptual model of the service concept that views services as perspectives on the use and offering of resources. The perspectives addressed by the model are: service as a means for abstraction; service as means for providing restricted access to resources; and service as a means for co-creation of value.

  • 184.
    Bergholtz, Maria
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Andersson, Birger
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Johannesson, Paul
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Towards a Model of Services Based on Cocreation, Abstraction and Rights Distribution2015Inngår i: Correct Software in Web Applications and Web Services / [ed] Bernhard Thalheim, Klaus-Dieter Schewe, Andreas Prinz, Bruno Buchberger, Cham: Springer, 2015, s. 29-44Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    The term service is today defined and used in a multitude of ways, which are often ambiguous and contradictory. The absence of a commonly agreed-upon definition of the term makes it difficult to distinguish, describe and classify services. In order to address these issues, this chapter proposes a model of services that helps in analysing the concept. The model encompasses three perspectives: service as a means for cocreation of value, service as a means for abstraction and service as a means for distributing rights. The model does not suggest a definition of the term service but shows how the service concept can be analysed using a number of related concepts, like service resource, service process and service offering. The model has its theoretical foundation in the Resource-Event-Agent (REA) ontology and Hohfeld’s classification of rights.

  • 185.
    Bergholtz, Maria
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Ekenberg, Love
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Hansson, Karin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Johannesson, Paul
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Snygg, Joakim
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Framework for evaluating tools used in edemocracy: transparency, autonomy, consensus and pluralism2014Inngår i: DSV Writers Hut 2014: proceedings  August 21-22, 2014, Åkersberga, Sweden, Stockholm: Stockholm University, 2014Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    The concept of e-democracy has been around for a while. However, the intercontextual understanding of this is still immature which complicates interdisciplinarity and communication with a diversity of stakeholders, resulting in a weak participation and implementation of e-services. This is even more emphasized in an international setting, not the least in the context of various European Union initiatives regarding e-service provision. To increase the participation in the context, e-democracy services can be utilized for strengthening individual capabilities as well as political processes. The effective design of such processes requires tools to support decision-making, collaboration, and collaborative decision-making, voting engagement and involvement in the democratic process. This article presents an evaluation framework suitable for tools for e-democracy aiming at forming a constructive base for implementing an efficient support for enabling an increased participation in vital democratic processes.

  • 186.
    Bergholtz, Maria
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Eriksson, Owen
    Johannesson, Paul
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Towards a Sociomaterial Ontology2013Inngår i: Advanced Information Systems Engineering Workshops: CAiSE 2013 International Workshops. Proceedings / [ed] Xavier Franch, Pnina Soffer, Springer Berlin/Heidelberg, 2013, s. 341-348Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The management of social phenomena in conceptual modelling requires a novel understanding of the notion of representation. In particular, the principles for the existence and identification of objects need to be reconsidered. To do this, the paper draws on the current ontological discourse in information systems engineering and proposes a sociomaterial ontology for supporting conceptual modeling. The ontology shows how organisational entities are grounded in physical ones and how they can be understood in terms of deontic notions like privileges, duties and powers. The sociomaterial ontology is able to assist designers in creating understandable and robust conceptual models.

  • 187.
    Bergholtz, Maria
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Johannesson, Paul
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Andersson, Birger
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Towards a model of services based on co-creation, abstraction and restriction2011Inngår i: International Conference on Conceptual Modeling (ER) 2011, Brussels: Springer , 2011Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The term service is today defined and used in a multitude of ways, and there is no usage characteristic that is common for all of these ways. As a consequence natural language terms used for describing services are ambiguous and often confusing. The lack of a common agreed upon definition of the term makes it difficult to understand and classify services as well as distinguish them from non-service concepts. In this paper, we do not propose a new definition of service but a model of services that helps in analysing the concept. The model is based on three perspectives: service as a means for co-creation of value, service as a means for abstraction, and service as a means for providing restricted access to resources.

  • 188. Berndorfer, Stefan
    et al.
    Henriksson, Aron
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Automated Diagnosis Coding with Combined Text Representations2017Inngår i: Studies in Health Technology and Informatics, ISSN 0926-9630, E-ISSN 1879-8365, Vol. 235, s. 201-2015Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Automated diagnosis coding can be provided efficiently by learning predictive models from historical data; however, discriminating between thousands of codes while allowing a variable number of codes to be assigned is extremely difficult. Here, we explore various text representations and classification models for assigning ICD-9 codes to discharge summaries in MIMIC-III. It is shown that the relative effectiveness of the investigated representations depends on the frequency of the diagnosis code under consideration and that the best performance is obtained by combining models built using different representations.

  • 189.
    Bernsel, Andreas
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Sequence-based predictions of membrane-protein topology, homology and insertion2008Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. This thesis focuses on prediction methods for membrane proteins that ultimately rely on their amino acid sequence only.

    By identifying soluble protein domains in membrane protein sequences, we were able to constrain and improve prediction of membrane protein topology, i.e. what parts of the sequence span the membrane and what parts are located on the cytoplasmic and extra-cytoplasmic sides. Using predicted topology as input to a profile-profile based alignment protocol, we managed to increase sensitivity to detect distant membrane protein homologs.

    Finally, experimental measurements of the level of membrane integration of systematically designed transmembrane helices in vitro were used to derive a scale of position-specific contributions to helix insertion efficiency for all 20 naturally occurring amino acids. Notably, position within the helix was found to be an important factor for the contribution to helix insertion efficiency for polar and charged amino acids, reflecting the highly anisotropic environment of the membrane. Using the scale to predict natural transmembrane helices in protein sequences revealed that, whereas helices in single-spanning proteins are typically hydrophobic enough to insert by themselves, a large part of the helices in multi-spanning proteins seem to require stabilizing helix-helix interactions for proper membrane integration. Implementing the scale to predict full transmembrane topologies yielded results comparable to the best statistics-based topology prediction methods.

  • 190.
    Berthet, Pierre
    Stockholms universitet, Naturvetenskapliga fakulteten, Numerisk analys och datalogi (NADA).
    Computational Modeling of the Basal Ganglia: Functional Pathways and Reinforcement Learning2015Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    We perceive the environment via sensor arrays and interact with it through motor outputs. The work of this thesis concerns how the brain selects actions given the information about the perceived state of the world and how it learns and adapts these selections to changes in this environment. Reinforcement learning theories suggest that an action will be more or less likely to be selected if the outcome has been better or worse than expected. A group of subcortical structures, the basal ganglia (BG), is critically involved in both the selection and the reward prediction.

    We developed and investigated a computational model of the BG. We implemented a Bayesian-Hebbian learning rule, which computes the weights between two units based on the probability of their activations. We were able test how various configurations of the represented pathways impacted the performance in several reinforcement learning and conditioning tasks. Then, following the development of a more biologically plausible version with spiking neurons, we simulated lesions in the different pathways and assessed how they affected learning and selection.

    We observed that the evolution of the weights and the performance of the models resembled qualitatively experimental data. The absence of an unique best way to configure the model over all the learning paradigms tested indicates that an agent could dynamically configure its action selection mode, mainly by including or not the reward prediction values in the selection process. We present hypotheses on possible biological substrates for the reward prediction pathway. We base these on the functional requirements for successful learning and on an analysis of the experimental data. We further simulate a loss of dopaminergic neurons similar to that reported in Parkinson’s disease. We suggest that the associated motor symptoms are mostly causedby an impairment of the pathway promoting actions, while the pathway suppressing them seems to remain functional.

  • 191.
    Berthet, Pierre
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Numerisk analys och datalogi (NADA). Royal Institute of Technology, Sweden.
    Hellgren-Kotaleski, Jeanette
    Lansner, Anders
    Stockholms universitet, Naturvetenskapliga fakulteten, Numerisk analys och datalogi (NADA). Royal Institute of Technology, Sweden.
    Action selection performance of a reconfigurable basal ganglia inspired model with Hebbian-Bayesian Go- NoGo connectivity2012Inngår i: Frontiers in Behavioral Neuroscience, ISSN 1662-5153, E-ISSN 1662-5153, Vol. 6, artikkel-id 65Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Several studies have shown a strong involvement of the basal ganglia (BG) in action selection and dopamine dependent learning. The dopaminergic signal to striatum, the input stage of the BG, has been commonly described as coding a reward prediction error (RPE), i.e., the difference between the predicted and actual reward. The RPE has been hypothesized to be critical in the modulation of the synaptic plasticity in cortico-striatal synapses in the direct and indirect pathway. We developed an abstract computational model of the BG, with a dual pathway structure functionally corresponding to the direct and indirect pathways, and compared its behavior to biological data as well as other reinforcement learning models. The computations in our model are inspired by Bayesian inference, and the synaptic plasticity changes depend on a three factor Hebbian-Bayesian learning rule based on co-activation of pre- and post-synaptic units and on the value of the RPE. The model builds on a modified Actor-Critic architecture and implements the direct (Go) and the indirect(NoGo) pathway, as well as the reward prediction (RP) system, acting in a complementary fashion. We investigated the performance of the model system when different configurations of the Go, NoGo, and RP system were utilized, e.g., using only the Go, NoGo, or RP system, or combinations of those. Learning performance was investigated in several types of learning paradigms, such as learning-relearning, successive learning, stochastic learning, reversal learning and a two-choice task. The RPE and the activity of the model during learning were similar to monkey electrophysiological and behavioral data. Our results, however, show that there is not a unique best way to configure this BG model to handle well all the learning paradigms tested. We thus suggest that an agent might dynamically configure its action selection mode, possibly depending on task characteristics and also on how much time is available.

  • 192.
    Berthet, Pierre
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Numerisk analys och datalogi (NADA). Royal Institute of Technology, Sweden.
    Lansner, Anders
    Stockholms universitet, Naturvetenskapliga fakulteten, Numerisk analys och datalogi (NADA). Royal Institute of Technology, Sweden.
    Optogenetic Stimulation in a Computational Model of the Basal Ganglia Biases Action Selection and Reward Prediction Error2014Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, nr 3, artikkel-id e90578Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Optogenetic stimulation of specific types of medium spiny neurons (MSNs) in the striatum has been shown to bias the selection of mice in a two choices task. This shift is dependent on the localisation and on the intensity of the stimulation but also on the recent reward history. We have implemented a way to simulate this increased activity produced by the optical flash in our computational model of the basal ganglia (BG). This abstract model features the direct and indirect pathways commonly described in biology, and a reward prediction pathway (RP). The framework is similar to Actor-Critic methods and to the ventral/ dorsal distinction in the striatum. We thus investigated the impact on the selection caused by an added stimulation in each of the three pathways. We were able to reproduce in our model the bias in action selection observed in mice. Our results also showed that biasing the reward prediction is sufficient to create a modification in the action selection. However, we had to increase the percentage of trials with stimulation relative to that in experiments in order to impact the selection. We found that increasing only the reward prediction had a different effect if the stimulation in RP was action dependent (only for a specific action) or not. We further looked at the evolution of the change in the weights depending on the stage of learning within a block. A bias in RP impacts the plasticity differently depending on that stage but also on the outcome. It remains to experimentally test how the dopaminergic neurons are affected by specific stimulations of neurons in the striatum and to relate data to predictions of our model.

  • 193.
    Berthet, Pierre
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Numerisk analys och datalogi (NADA).
    Lindahl, Mikael
    Tully, Philip
    Hellgren-Kotaleski, Jeanette
    Lansner, Anders
    Stockholms universitet, Naturvetenskapliga fakulteten, Numerisk analys och datalogi (NADA).
    Functional relevance of different basal ganglia pathways investigated in a spiking model with reward dependent plasticityManuskript (preprint) (Annet vitenskapelig)
  • 194. Berzisa, Solvita
    et al.
    Bravos, George
    Cardona Gonzalez, Tania
    Czubayko, Ulrich
    Espana, Sergio
    Grabis, Janis
    Henkel, Martin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Jokste, Lauma
    Kampars, Janis
    Koc, Hasan
    Kuhr, Jan-Christian
    Llorca, Carlos
    Loucopoulos, Pericles
    Juanes Pascual, Raul
    Pastor, Oscar
    Sandkuhl, Kurt
    Simic, Hrvoje
    Stirna, Janis
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Girome Valverde, Francisco
    Zdravkovic, Jelena
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Capability Driven Development: An Approach to Designing Digital Enterprises2015Inngår i: Business & Information Systems Engineering, ISSN 1867-0202, Vol. 57, nr 1, s. 15-25Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The need for organizations to operate in changing environments is addressed by proposing an approach that integrates organizational development with information system (IS) development taking into account changes in the application context of the solution. This is referred to as Capability Driven Development (CDD). A meta-model representing business and IS designs consisting of goals, key performance indicators, capabilities, context and capability delivery patterns, is being proposed. The use of themeta-model is validated in three industrial case studies as part of an ongoing collaboration project, whereas one case is presented in the paper. Issues related to the use of the CDD approach, namely, CDD methodology and tool support are also discussed.

  • 195.
    Beskow, Jonas
    et al.
    KTH Speech, Music and Hearing.
    Carlson, Rolf
    KTH Speech, Music and Hearing.
    Edlund, Jens
    KTH Speech, Music and Hearing.
    Granström, Björn
    KTH Speech, Music and Hearing.
    Heldner, Mattias
    KTH Speech, Music and Hearing.
    Hjalmarsson, Anna
    KTH Speech, Music and Hearing.
    Skantze, Gabriel
    KTH Speech, Music and Hearing.
    Multimodal Interaction Control2009Inngår i: Computers in the Human Interaction Loop / [ed] Waibel, Alex and Stiefelhagen, Rainer, Berlin/Heidelberg: Springer Berlin/Heidelberg, 2009, s. 143-158Kapittel i bok, del av antologi (Fagfellevurdert)
  • 196.
    Beskow, Jonas
    et al.
    KTH Speech, Music and Hearing.
    Edlund, Jens
    KTH Speech, Music and Hearing.
    Gustafson, Joakim
    KTH Speech, Music and Hearing.
    Heldner, Mattias
    KTH Speech, Music and Hearing.
    Hjalmarsson, Anna
    KTH Speech, Music and Hearing.
    House, David
    KTH Speech, Music and Hearing.
    Research focus: Interactional aspects of spoken face-to-face communication2010Inngår i: Proceedings from Fonetik 2010, Lund: Lund University , 2010, s. 7-10Konferansepaper (Annet vitenskapelig)
  • 197.
    Bider, Ilia
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    AGILE RESEARCH IN INFORMATION SYSTEMS FIELD: ANALYSIS FROM KNOWLEDGE TRANSFORMATION PERSPECTIVE2015Inngår i: Proceedings of the 8th IADIS International Conference on Information Systems 2015 / [ed] Miguel Baptista Nunes, Pedro Isaías, Philip Powell, IADIS Press, 2015, s. 3-10Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Due to the relative success of agile methods in software development, the idea of having agile processes started to be tested in other areas, for example, agile business process development. This trend already reached the research community and there have appeared some materials that suggest using agility in research projects. Analysis of these suggestions, however, shows that they do not go beyond finding superficial analogy between the concepts of the software development and research projects. The paper presents a deeper analysis of the concept of agile research in Information Systems (IS) based on the analysis of the research projects from the knowledge transformation perspective. As a basis for analysis, the SECI model of Nonaka is used. Based on this analysis, several suggestions are made on how to conduct agile research in IS, e.g. prioritize relevance over vigor, test early for a practical purpose, use own experience and reflections, etc. It is also shown that some research types, like action research and design science, are more suitable for conducting agile research than others. The paper also gives analysis of risks of non-agile research, and presents an example where they are revealed.    

  • 198.
    Bider, Ilia
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Analysis of Agile Software Development from the Knowledge Transformation Perspective2014Inngår i: Perspectives in business informatics research: 13th International Conference, BIR 2014, Lund, Sweden, September 22-24, 2014. Proceedings / [ed] Björn Johansson, Berlin: Springer, 2014, s. 143-157Konferansepaper (Fagfellevurdert)
    Abstract [en]

    While the Agile Software Development (ASD) has been successfully promoted in the last 15 years, there is no agreement on how to determine whether a particular project is agile or not. Some practitioners consider agility as strict usage of a specific methodology, e.g. SCRUM, others consider agility as adhering to Agile Manifesto. The lack of common view on ASD prevents creating common guidelines on when the usage of ASD is appropriate. This paper presents a model of ASD that helps to differentiate it from the traditional, phase-based development, and more strictly defines the area of its applicability. The model has been built based on the knowledge transformation perspective, as the author considers it to be the most differentiating perspective when comparing ASD to traditional software development. For building the model, the ideas from SECI model of Nonaka have been exploited. The results, in the form of requirements to be fulfilled for successful employment of ASD, are demonstrated through analysis of completed ASD projects.

  • 199.
    Bider, Ilia
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Analyzing communication capabilities of CM/ACM systems with the help of Language/Action perspective2015Inngår i: Thriving on Adaptability: best practices for knowledge workers, Lighthouse Point: Future Strategies Inc. , 2015Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 200.
    Bider, Ilia
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Can the systems perspective help in attaining success in software engineering projects? Inquiry into the area of applicability for agile software development2015Inngår i: Software Engineering in the Systems Context: addressing frontiers, practice and education. / [ed] Ivar Jacobson, Harold "Bud" Lawson, London: College Publications, 2015, nr 1Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    The paper is devoted to finding out whether employing the systems perspective can help in converting the tacit knowledge of expert software engineers into an explicit form to be transferred to novices and non-technical stakeholders of the software projects. It suggests a simple framework, dubbed SPC, that is based on distinguishing three interconnected systems involved in a software development projects: the software itself (S), the software project (P), and the context in which the software is or to be deployed (C). The usefulness of the framework is demonstrated on using SPC for determining the area of applicability of the agile software development. This is accomplished by building models of traditional and agile software development projects and analyzing the properties of these models. The models are built based on the knowledge transformation perspective, as the author considers it to be the most differentiating perspective between the agile and traditional software development. For building the models, the ideas from SECI model of Nonaka have been used. In addition, the paper presents some ideas on how the SPC framework can be used for analyzing other issues related to software development.

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