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  • 251.
    Björkholm, Patrik
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Protein Interactions from the Molecular to the Domain Level2014Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The basic unit of life is the cell, from single-cell bacteria to the largest creatures on the planet. All cells have DNA, which contains the blueprint for proteins. This information is transported in the form of messenger RNA from the genome to ribosomes where proteins are produced. Proteins are the main functional constituents of the cell, they usually have one or several functions and are the main actors in almost all essential biological processes. Proteins are what make the cell alive. Proteins are found as solitary units or as part of large complexes. Proteins can be found in all parts of the cell, the most common place being the cytoplasm, a central space in all cells. They are also commonly found integrated into or attached to various membranes.

    Membranes define the cell architecture. Proteins integrated into the membrane have a wide number of responsibilities: they are the gatekeepers of the cell, they secrete cellular waste products, and many of them are receptors and enzymes.

    The main focus of this thesis is the study of protein interactions, from the molecular level up to the protein domain level.

    In paper I use reoccurring local protein structures to try and predict what sections of a protein interacts with another part using only sequence information. In papers II and III we use a randomization approach on a membrane protein motif that we know interacts with a sphingomyelin lipid to find other candidate proteins that interact with sphingolipids. These are then experimentally verified as sphingolipid-binding. In the last paper, paper IV, we look at how protein domain interaction networks overlap and can be evaluated.

  • 252.
    Björkholm, Patrik
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Ernst, Andreas
    Hacke, Moritz
    Wieland, Felix
    Brügger, Britta
    von Heijne, Gunnar
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Identification of novel sphingolipid-binding motifs in mammalian membrane proteinsManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Specific interactions between transmembrane proteins and sphingolipids is a poorly understood phenomenon, and only a couple of instances have been identified. The best characterized example is the sphingolipid-binding motif VXXTLXXIY found in the transmembrane helix of the vesicular transport protein p24. Here, we have used a simple motif- probability algorithm (MOPRO) to identify proteins that contain putative sphingolipid-binding motifs in a dataset comprising full proteomes from mammalian organisms. Four selected candidate proteins all tested positive for sphingolipid binding in a photoaffinity assay. The putative sphingolipid-binding motifs are noticeably enriched in the 7TM family of G-protein coupled receptors, predominantly in transmembrane helix 6. 

  • 253. Björkqvist, Olof
    et al.
    Larsson, Aron
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Idefeldt, Jim
    Risk Assessment of New Pricing Strategies in the District Heating Market: A Case Study at Sundsvall Energi AB2010Inngår i: Energy Policy, ISSN 0301-4215, E-ISSN 1873-6777, Vol. 38, nr 5, s. 2171-2178Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The price structure of district heating has been no major scientific issue for the last decades in energy-related research. However, today trends in district heating pricing tend to move towards a more customer-oriented approach with predetermined prices under a longer periods, leading to a more complex price structure. If a district heating supplier offers district heating with predetermined prices in order to compete with similar electricity offers, the financial risk of the new price structure is significantly higher than the risk of an ordinary variable cost offer based on short-run marginal cost. In contrary to an electricity seller, the district heating company cannot transfer all of the risk of predetermined prices to the financial market, instead the company is thrown upon its own ability to handle the risk by, e.g., hedging its own energy purchase. However, all uncertainties cannot be coped with in this manner. Thus, there is a need for a methodology that can be used to estimate the financial risk of different price structures and to value different opportunities to reduce the risk. In this article, we propose a methodology, implemented in prototype software, to evaluate the risk associated with new price structures in district heating.

  • 254. Bloom, Bard
    et al.
    Field, John
    Nystrom, Nathaniel
    Oestlund, Johan
    Richards, Gregor
    Strnisa, Rok
    Vitek, Jan
    Wrigstad, Tobias
    Stockholms universitet, Humanistiska fakulteten, Institutionen för nordiska språk.
    Thorn-Robust, Concurrent, Extensible Scripting on the JVM2009Inngår i: SIGPLAN notices, ISSN 0362-1340, E-ISSN 1558-1160, Vol. 44, nr 10, s. 117-136Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Scripting languages enjoy great popularity due to their support for rapid and exploratory development. They typically have lightweight syntax, weak data privacy, dynamic typing, powerful aggregate data types, and allow execution of the completed parts of incomplete programs. The price of these features comes later in the software life cycle. Scripts are hard to evolve and compose, and often slow. An additional weakness of most scripting languages is lack of support for concurrency-though concurrency is required for scalability and interacting with remote services. This paper reports on the design and implementation of Thorn, a novel programming language targeting the JVM. Our principal contributions are a careful selection of features that support the evolution of scripts into industrial grade programs-e.g., an expressive module system, an optional type annotation facility for declarations, and support for concurrency based on message passing between lightweight, isolated processes. On the implementation side, Thorn has been designed to accommodate the evolution of the language itself through a compiler plugin mechanism and target the Java virtual machine.

  • 255.
    Blåsjö, Mona
    et al.
    Stockholms universitet, Humanistiska fakulteten, Institutionen för nordiska språk.
    Knutsson, Ola
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Cerratto-Pargman, Teresa
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Exploring the Design Space of Genre Pedagogy and Virtual Learning Environments2012Inngår i: Designs for Learning 2012: 3rd International Conference Exploring Learning Environments. Conference Proceedings, 2012, s. 75-77Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This paper explores the design space of genre pedagogy and virtual learning environments. This is done by examining the cornerstones of genre pedagogy and the main activities they give raise to, and how the activities are transformed when they are partly or completely moved from the classroom to virtual learning environments, and what implications for interaction design they give raise to.

  • 256. Boella, Guido
    et al.
    Noriega, Pablo
    Pigozzi, Gabriella
    Verhagen, Harko
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Introduction to the special issue on NorMAS 20092013Inngår i: Journal of logic and computation (Print), ISSN 0955-792X, E-ISSN 1465-363X, Vol. 23, nr 2, s. 307-308Artikkel i tidsskrift (Annet vitenskapelig)
  • 257. Boella, Guido
    et al.
    Pigozzi, Gabriella
    Singh, Munindar
    Verhagen, Harko
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Normative Multiagent Systems: Guest Editors’ Introduction2010Inngår i: Logic Journal of the IGPL, Vol. 18, nr 1, s. 1-3Artikkel i tidsskrift (Fagfellevurdert)
  • 258. Boella, Guido
    et al.
    van der Torre, Leendert
    Verhagen, Harko
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Introduction to Normative Multiagent Systems2006Inngår i: Computational and mathematical organization theory, ISSN 1381-298X, E-ISSN 1572-9346, Vol. 12, nr 2-3, s. 71-79Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article introduces the research issues related to and definition of normative multiagent systems. It also describes the papers selected from NorMAS05 that are part of this double special issue and relates the papers to each other.

  • 259.
    Boella, Guido
    et al.
    Universita di Torino, , Dipartimento di Informatica.
    van der Torre, Leendert
    University of Luxembourg, , Computer Science and Communication Research Unit.
    Verhagen, Harko
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Ten Challenges for Normative Multiagent Systems2008Inngår i: Programming Multi-Agent Systems, Programming Multi-Agent Systems , 2008Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In this paper we discuss the shift from a legal to an interactionist view on normative multiagent systems, examples, and ten new challenges in this more dynamic setting.

  • 260.
    Boeva, Veselka
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Ekenberg, Love
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    A transition logic for schemata conflicts2004Inngår i: Data & Knowledge Engineering, ISSN 0169-023X, E-ISSN 1872-6933, Vol. 51, nr 3, s. 277-294Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conflict detection and analysis are of high importance, e.g., when integrating conceptual schemata, such as UML-Specifications, or analysing goal-fulfilment of sets of autonomous agents. In general, models for this introduce unnecessarily complicated frameworks with several disadvantages regarding semantics as well as complexity. This paper demonstrates that an important set of static and dynamic conflicts between specifications can be diagnosed using ordinary first-order modal logic. Furthermore, we show how the framework can be extended for handling situations when there are convex sets of probability measures over a state-space. Thus, representing specifications as conceptual schemata and using standard Kripke models of modal logic, augmented with an interval-valued probability measure, we propose instrumental definitions and procedures for conflict detection.

  • 261.
    Bohman, Samuel
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Civic Participation and Empowerment through Visualization2015Inngår i: Proceedings of SIGRAD 2015, June 1st and 2nd, Stockholm, Sweden / [ed] Christopher E. Peters and Lars Kjelldahl, Linköping: Linköping University Electronic Press, 2015, s. 20-23Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This article elaborates on the use of data visualization to promote civic participation and democratic engagement. The power and potential of data visualization is examined through a brief historical overview and four interconnected themes that provide new opportunities for electronic participation research: data storytelling, infographics, data physicalization, and quantified self. The goal is to call attention to this space and encourage a larger community of researchers to explore the possibilities that data visualization can bring.

  • 262.
    Bohman, Samuel
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Data Visualization: An Untapped Potential for Political Participation and Civic Engagement2015Inngår i: Electronic Government and the Information Systems Perspective: 4th International Conference, EGOVIS 2015, Valencia, Spain, September 1-3, 2015, Proceedings / [ed] Andrea Kö, Enrico Francesconi, Springer, 2015, s. 302-315Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This article elaborates on the use of data visualization to promote a more informed and engaged participation in civic and democratic life. First, it outlines the main constraints and challenges in electronic participation research and concludes that the conventional deliberative approach to political participation has been impeding civic engagement. Then, through a couple of recent examples and a brief historical overview, it examines the power of data visualization. Following this, it explores the democratization of data visualization through four interconnected themes that provide new opportunities for political participation and civic engagement research: data storytelling, infographics, data physicalisation, and the quantified self. The goal is to call attention to this space and encourage a larger community of researchers to explore the possibilities that data visualization can bring.

  • 263.
    Bohman, Samuel
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Information Technology in eParticipation Research: A Word Frequency Analysis2014Inngår i: Electronic Participation: Proceedings, Springer Berlin/Heidelberg, 2014, s. 78-89Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Recent literature and project reviews suggest information technology is inadequately reflected in eParticipation research. This study uses text search queries to investigate the occurrence of 60 technology categories in a bibliographic database consisting of over a thousand research articles. The results show that eParticipation research have overwhelmingly focused on websites and discussion forums as the main technologies under study. Many other technologies that are frequently mentioned in overview articles as being part of eParticipation have received relatively scant attention in actual research. This article presents findings that may be useful in broadening and deepening the field’s treatment of technology.

  • 264.
    Bohman, Samuel
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Hansson, Henrik
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Mobini, Pooyeh
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Online participation in higher education decision-making: a mixed methods study of the MyUniversity EU-project2014Inngår i: eJournal of eDemocracy and Open Government, ISSN 2075-9517, Vol. 6, s. 267-285Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article considers online participation in higher education decision-making using the MyUniversity EU project as a case study. MyUniversity was a pilot designed to provide European universities with a web-based system to empower and involve students and other members of the academic community in the Bologna Process. Thirteen universities in Spain, Slovakia, Bulgaria, and Lithuania participated in trials. The study uses data collection methods from across the quantitative and qualitative spectrum: web analytics, online surveys, key performance indicators, interviews, focus groups, participant observation, document studies, and usability evaluations. The results are represented by 10 themes: project design, participation, functionality and usability, impact on decision-making, privacy and trust, institutional resistance, motivational factors, the political, economic, and sociocultural context, language barriers, and moderation and framing. The article ends with a discussion based on the results, including recommendations for future research.

  • 265.
    Bohman, Samuel
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Kalinina, Maria
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Larsson, Aron
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Trade-off in statistical design process2012Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    The design and planning of a statistical survey can be regarded as a complex decision process involving multiple stakeholders and a diverse set of users. The process involves finding a balance between statistical quality, burden on respondents and costs. Our research is aimed towards developing a prototype system consisting of computational core based on the combination of multi-objective optimization, multi-criteria analysis, and a user-friendly interface. The overall objective of the research is to maximize statistical quality while minimizing the burden on respondents and costs.

  • 266. Bolelli, K.
    et al.
    Musdal, Yaman
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
    Aki-Yalcin, E.
    Mannervik, Bengt
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
    Yalcin, I.
    Synthesis and activity mechanism of some novel 2-substituted benzothiazoles as hGSTP1-1 enzyme inhibitors2017Inngår i: SAR and QSAR in environmental research (Print), ISSN 1062-936X, E-ISSN 1029-046X, Vol. 28, nr 11, s. 927-940Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Human GSTP1-1 is one of the most important proteins, which overexpresses in a large number of human tumours and is involved in the development of resistance to several anticancer drugs. So, it has become an important target in cancer treatment. In this study, 12 benzothiazole derivatives were synthesized and screened for their in vitro inhibitory activity for hGSTP1-1. Among these compounds, two of them (compounds #2 and #5) have been found to be the leads when compared with the reference drug etoposide. In order to analyse the structure-activity relationships (SARs) and to investigate the binding side interactions of the observed lead compounds, a HipHop pharmacophore model was generated and the molecular docking studies were performed by using CDocker method. In conclusion, it is observed that the lead compounds #2 and #5 possessed inhibitory activity on the hGSTP1-1 by binding to the H-site as a substrate in which the para position of the phenyl ring of the benzamide moiety on the benzothiazole ring is important. Substitution at this position with a hydrophobic group that reduces the electron density at the phenyl ring is required for the interaction with the H side active residue Tyr108.

  • 267.
    Boman, Magnus
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Holm, Einar
    Multi-agent systems, time geography, and microsimulations2004Inngår i: Systems Approaches and their Application / [ed] Olsson, M-O. and Sjöstedt, G., Boston: Kluwer Academic , 2004Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 268. Bonnay, Denis
    et al.
    Westerståhl, Dag
    Stockholms universitet, Humanistiska fakulteten, Filosofiska institutionen.
    Dynamic Versus Classical Consequence2014Inngår i: Johan van Benthem on Logic and Information Dynamics / [ed] Baltag, A.; Smets, S., Dordrecht: Springer, 2014, Vol. 5, s. 837-854Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    The shift of interest in logic from just reasoning to all forms of information flow has considerably widened the scope of the discipline, as amply illustrated in Johan van Benthem's recent book Logical Dynamics of Information and Interaction. But how much does this change when it comes to the study of traditional logical notions such as logical consequence? We propose a systematic comparison between classical consequence, explicated in terms of truth preservation, and a dynamic notion of consequence, explicated in terms of information flow. After a brief overview of logical consequence relations and the distinctive features of classical consequence, we define classical and dynamic consequence over abstract information frames. We study the properties of information under which the two notions prove to be equivalent, both in the abstract setting of information frames and in the concrete setting of Public Announcement Logic. The main lesson is that dynamic consequence diverges from classical consequence when information is not persistent, which is in particular the case of epistemic information about what we do not yet know. We end by comparing our results with recent work by Rothschild and Yalcin on the conditions under which the dynamics of information updates can be classically represented. We show that classicality for consequence is strictly less demanding than classicality for updates. Johan van Benthem's recent book Logical Dynamics of Information and Interaction [8] can be seen as a passionate plea for a radically new view of logic. To be sure, the book is not a philosophical discussion of what logic is but rather an impressive series of illustrations of what logic can be, with presentations of numerous logical languages and a wealth of meta-logical results about them. The view is called simply Logical Dynamics, and contrasted with more traditional views of logic, and also with the earlier view from e.g. [5], now called Pluralism, in which logic was seen as the study of consequence relations. According to Logical Dynamics, logic is not only about reasoning, about what follows from what, but about all aspects of information flow among rational agents. Not just proof and inference, but observations, questions, announcements, communication, plans, strategies, etc. are first-class citizens in the land of Logic. And not only the output of these activities belong to logic, but also the processes leading up to it. This is a fascinating and inspiring view of logic. But how different is it from a more standard view? In particular, what does it change for the analysis of logical consequence, which had been the focus of traditional logical enquiry? This paper attempts some answers to the latter question, with a view to get clearer about the former.

  • 269. Boonman, Hettie J.
    et al.
    Siddiqui, Afzal S.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap. University College London, UK; HEC Montréal, Canada.
    Capacity optimization under uncertainty: The impact of operational time lags2017Inngår i: European Journal of Operational Research, ISSN 0377-2217, E-ISSN 1872-6860, Vol. 262, nr 2, s. 660-672Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Time lags in switching operational modes are typical in the manufacturing and power sectors but are not treated in most real options models. In this paper, we consider a firm that has the opportunity to suspend and to resume production infinitely many times subject to a time lag after each startup decision. We contribute to the literature by allowing the firm to determine its level of installed capacity in conjunction with its optimal investment timing. We find that an increase in the length of the time lag results in an increase in the optimal capacity level. Capacity optimization also interacts with the length of the time lag to affect investment timing and the triggers to suspend and resume production, thereby weakening the result about hysteresis from a standard real options model. Under the assumption of a fixed level of capacity, a longer lag speeds up the decision to resume operations due to a positive upside to the revenue but delays the suspension of operations. By contrast, with capacity optimization, a longer time lag results in a larger capacity choice, which can indirectly delay the investment decision and the timing to resume operations. This indirect effect dominates when the level of market uncertainty is low and the time lag is initially small.

  • 270.
    Borg Gyllenbäck, Katarina
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Boman, Magnus
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Narrative Bridging2011Inngår i: Design Computing and Cognition ’10 / [ed] John S. Gero, Berlin: Springer Verlag , 2011, s. 525-544Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In the design of interactive media, various forms of intuitive practice come into play. It might prove tempting to use templates and strong narrative structures instead of developing the narrative directly for interactive media. This leads towards computer implementation too swiftly. The narrative bridging method focuses on the initial design phase, in which the conceptual modeling takes place. The purpose is to provide designers with a non-intrusive method that supports the design process without interfering with its creative elements. The method supports the sentient construction of digital games with a narrative, with the ultimate goal of enhancing the player’s experience. A prototype test served as a first evaluation, and two games from that test are showcased here for the purpose of illustrating the hands-on use of narrative bridging. The test demonstrated that the method could aid time-constrained design, and in the process detect inconsistencies that could prevent the design team from making improvements. The method also provided teams with a shared vocabulary and outlook.

  • 271. Borking, Kjell
    et al.
    Danielson, Mats
    Davies, Guy
    Ekenberg, Love
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Idefeldt, Jim
    Larsson, Aron
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Transcending Business Intelligence2011Bok (Annet vitenskapelig)
  • 272. Borking, Kjell
    et al.
    Danielson, Mats
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Ekenberg, Love
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Idefeldt, Jim
    Larsson, Aron
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Bortom Business Intelligence2009 (oppl. 1)Bok (Annet vitenskapelig)
  • 273. Bornemann, Leon
    et al.
    Lecerf, Jason
    Papapetrou, Panagiotis
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    STIFE: A Framework for Feature-based Classification of Sequences of Temporal Intervals2016Inngår i: Discovery Science: 19th International Conference, DS 2016, Bari, Italy, October 19–21, 2016, Proceedings / [ed] Toon Calders, Michelangelo Ceci, Donato Malerba, Springer, 2016, s. 85-100Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In this paper, we study the problem of classification of sequences of temporal intervals. Our main contribution is the STIFE framework for extracting relevant features from interval sequences to build feature-based classifiers. STIFE uses a combination of basic static metrics, shapelet discovery and selection, as well as distance-based approaches. Additionally, we propose an improved way of computing the state of the art IBSM distance measure between two interval sequences, that reduces both runtime and memory needs from pseudo-polynomial to fully polynomial, which greatly reduces the runtime of distance based classification approaches. Our empirical evaluation not only shows that STIFE provides a very fast classification time in all evaluated scenarios but also reveals that a random forests using STIFE achieves similar or better accuracy than the state of the art k-NN classifier.

  • 274. Bornoe, Nis
    et al.
    Barkhuus, Louise
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    TagPad: Supporting Field Interviews and Analysis2013Inngår i: iConference 2013 Proceedings / [ed] Linda Schamber, iShools , 2013, s. 316-325Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The area of cyberinfrastructures has looked extensively at research within the natural sciences, however, the social sciences have been largely overlooked in terms of novel data collection and analysis systems. We developed a probe tool, TagPad, to look at the process for social science data collection through interviews and surveys. Our research participants found that TagPad facilitated structuring of interviews but we also found that the setting in which the interview takes place is essential to the success of using this particular tool. We conclude suggesting future designs of social science research tools.

  • 275.
    Boström, Henrik
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Concurrent Learning of Large-Scale Random Forests2011Inngår i: Scandinavian Conference on Artificial Intelligence, IOS Press , 2011Konferansepaper (Fagfellevurdert)
  • 276.
    Boström, Henrik
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Estimating Class Probabilities in Random Forests2007Inngår i: Proceedings of the Sixth International Conference on Machine Learning and Applications, IEEE , 2007, s. 211-216Konferansepaper (Fagfellevurdert)
    Abstract [en]

    For both single probability estimation trees (PETs) and ensembles of such trees, commonly employed class probability estimates correct the observed relative class frequencies in each leaf to avoid anomalies caused by small sample sizes. The effect of such corrections in random forests of PETs is investigated, and the use of the relative class frequency is compared to using two corrected estimates, the Laplace estimate and the m-estimate. An experiment with 34 datasets from the UCI repository shows that estimating class probabilities using relative class frequency clearly outperforms both using the Laplace estimate and the m-estimate with respect to accuracy, area under the ROC curve (AUC) and Brier score. Hence, in contrast to what is commonly employed for PETs and ensembles of PETs, these results strongly suggest that a non-corrected probability estimate should be used in random forests of PETs. The experiment further shows that learning random forests of PETs using relative class frequency significantly outperforms learning random forests of classification trees (i.e., trees for which only an unweighted vote on the most probable class is counted) with respect to both accuracy and AUC, but that the latter is clearly ahead of the former with respect to Brier score.

  • 277.
    Boström, Henrik
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Feature vs. Classifier Fusion for Predictive Data - a Case Study in Pesticide Classification2007Inngår i: Proceedings of the 10th International Conference on Information Fusion, IEEE , 2007, s. 1-7Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Two strategies for fusing information from multiple sources when generating predictive models in the domain of pesticide classification are investigated: i) fusing different sets of features (molecular descriptors) before building a model and ii) fusing the classifiers built from the individual descriptor sets. An empirical investigation demonstrates that the choice of strategy can have a significant impact on the predictive performance. Furthermore, the experiment shows that the best strategy is dependent on the type of predictive model considered. When generating a decision tree for pesticide classification, a statistically significant difference in accuracy is observed in favor of combining predictions from the individual models compared to generating a single model from the fused set of molecular descriptors. On the other hand, when the model consists of an ensemble of decision trees, a statistically significant difference in accuracy is observed in favor of building the model from the fused set of descriptors compared to fusing ensemble models built from the individual sources.

  • 278. Boström, Henrik
    et al.
    Asker, Lars
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Gurung, Ram
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Karlsson, Isak
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Lindgren, Tony
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Papapetrou, Panagiotis
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Conformal prediction using random survival forests2017Inngår i: 16th IEEE International Conference on Machine Learning and Applications: Proceedings / [ed] Xuewen Chen, Bo Luo, Feng Luo, Vasile Palade, M. Arif Wani, Institute of Electrical and Electronics Engineers (IEEE), 2017, s. 812-817Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Random survival forests constitute a robust approach to survival modeling, i.e., predicting the probability that an event will occur before or on a given point in time. Similar to most standard predictive models, no guarantee for the prediction error is provided for this model, which instead typically is empirically evaluated. Conformal prediction is a rather recent framework, which allows the error of a model to be determined by a user specified confidence level, something which is achieved by considering set rather than point predictions. The framework, which has been applied to some of the most popular classification and regression techniques, is here for the first time applied to survival modeling, through random survival forests. An empirical investigation is presented where the technique is evaluated on datasets from two real-world applications; predicting component failure in trucks using operational data and predicting survival and treatment of heart failure patients from administrative healthcare data. The experimental results show that the error levels indeed are very close to the provided confidence levels, as guaranteed by the conformal prediction framework, and that the error for predicting each outcome, i.e., event or no-event, can be controlled separately. The latter may, however, lead to less informative predictions, i.e., larger prediction sets, in case the class distribution is heavily imbalanced.

  • 279.
    Boström, Henrik
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Dalianis, Hercules
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    De-identifying health records by means of active learning2012Inngår i:  , 2012Konferansepaper (Fagfellevurdert)
    Abstract [en]

    An experiment on classifying words in Swedish health records as belonging to one of eight protected health information (PHI) classes, or to the non-PHI class, by means of active learning has been conducted, in which three selection strategies were evaluated in conjunction with random forests; the commonly employed approach of choosing the most uncertain examples, choosing randomly, and choosing the most certain examples. Surprisingly, random selection outperformed choosing the most uncertain examples with respect to ten considered performance metrics. Moreover, choosing the most certain examples outperformed random selection with respect to nine out of ten metrics.

  • 280.
    Boström, Henrik
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Knobbe, ArnoSoares, CarlosPapapetrou, PanagiotisStockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Advances in Intelligent Data Analysis XV: 15th International Symposium, IDA 2016, Stockholm, Sweden, October 13-15, 2016, Proceedings2016Konferanseproceedings (Fagfellevurdert)
    Abstract [en]

    This book constitutes the refereed conference proceedings of the 15th International Conference on Intelligent Data Analysis, which was held in October 2016 in Stockholm, Sweden. The 36 revised full papers presented were carefully reviewed and selected from 75 submissions. The traditional focus of the IDA symposium series is on end-to-end intelligent support for data analysis. The symposium aims to provide a forum for inspiring research contributions that might be considered preliminary in other leading conferences and journals, but that have a potentially dramatic impact.

  • 281.
    Boström, Henrik
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Linusson, Henrik
    Lofstrom, Tuve
    Johansson, Ulf
    Accelerating difficulty estimation for conformal regression forests2017Inngår i: Annals of Mathematics and Artificial Intelligence, ISSN 1012-2443, E-ISSN 1573-7470, Vol. 81, nr 1-2, s. 125-144Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The conformal prediction framework allows for specifying the probability of making incorrect predictions by a user-provided confidence level. In addition to a learning algorithm, the framework requires a real-valued function, called nonconformity measure, to be specified. The nonconformity measure does not affect the error rate, but the resulting efficiency, i.e., the size of output prediction regions, may vary substantially. A recent large-scale empirical evaluation of conformal regression approaches showed that using random forests as the learning algorithm together with a nonconformity measure based on out-of-bag errors normalized using a nearest-neighbor-based difficulty estimate, resulted in state-of-the-art performance with respect to efficiency. However, the nearest-neighbor procedure incurs a significant computational cost. In this study, a more straightforward nonconformity measure is investigated, where the difficulty estimate employed for normalization is based on the variance of the predictions made by the trees in a forest. A large-scale empirical evaluation is presented, showing that both the nearest-neighbor-based and the variance-based measures significantly outperform a standard (non-normalized) nonconformity measure, while no significant difference in efficiency between the two normalized approaches is observed. The evaluation moreover shows that the computational cost of the variance-based measure is several orders of magnitude lower than when employing the nearest-neighbor-based nonconformity measure. The use of out-of-bag instances for calibration does, however, result in nonconformity scores that are distributed differently from those obtained from test instances, questioning the validity of the approach. An adjustment of the variance-based measure is presented, which is shown to be valid and also to have a significant positive effect on the efficiency. For conformal regression forests, the variance-based nonconformity measure is hence a computationally efficient and theoretically well-founded alternative to the nearest-neighbor procedure.

  • 282.
    Boström, Henrik
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Linusson, Henrik
    Löfström, Tuve
    Johansson, Ulf
    Evaluation of a Variance-Based Nonconformity Measure for Regression Forests2016Inngår i: Conformal and Probabilistic Prediction with Applications: 5th International Symposium, COPA 2016, Madrid, Spain, April 20-22, 2016, Proceedings / [ed] Alexander Gammerman, Zhiyuan Luo, Jesús Vega, Vladimir Vovk, Springer, 2016, s. 75-89Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In a previous large-scale empirical evaluation of conformal regression approaches, random forests using out-of-bag instances for calibration together with a k-nearest neighbor-based nonconformity measure, was shown to obtain state-of-the-art performance with respect to efficiency, i.e., average size of prediction regions. However, the use of the nearest-neighbor procedure not only requires that all training data have to be retained in conjunction with the underlying model, but also that a significant computational overhead is incurred, during both training and testing. In this study, a more straightforward nonconformity measure is investigated, where the difficulty estimate employed for normalization is based on the variance of the predictions made by the trees in a forest. A large-scale empirical evaluation is presented, showing that both the nearest-neighbor-based and the variance-based measures significantly outperform a standard (non-normalized) nonconformity measure, while no significant difference in efficiency between the two normalized approaches is observed. Moreover, the evaluation shows that state-of-the-art performance is achieved by the variance-based measure at a computational cost that is several orders of magnitude lower than when employing the nearest-neighbor-based nonconformity measure.

  • 283. Botezatu, Mihaela
    et al.
    Hult, Håkan
    Kassaye Tessma, Mesfin
    Fors, Uno
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Virtual patient simulation for learning and assessment: superior results in comparison with regular course exams2010Inngår i: Medical Teacher, ISSN 0142-159X, Vol. 32, nr 10, s. 845-850Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    

    Background: Our study aimed to observe the differences in assessment results between virtual patient simulation (VPS) and regular course exams in an Internal Medicine course for undergraduate medical students.

    Methods: Four cohorts of students (n = 216) used: a VPS or lectures for learning (terms 1 and 2); VPS and lectures or only lectures (term 3); and a paired set-up with both VPS and lectures (term 4). The assessment results, measured with both a VPS-based exam and a paper-based exam, were compared. A scoring rubric (0–6), developed and validated for the purpose of the trial, was applied to both types of assessment. Mean score differences of the results were compared for the four cohorts.

    Results: Both VPS and regular examination results were significantly higher in the VPS group compared to regular exam group (p < 0.001) in terms 1, 2 and 3. The paired mean difference in term 4 was 0.66 (95% confidence interval (CI) 0.50, 0.83; p < 0.001) for haematology and 0.57 (95% CI 0.45, 0.69; p < 0.001) for cardiology.

    Conclusion: Our findings suggest that using VPS both for learning and for assessment supports learning. VPS are better than traditional assessment methods when the virtual application is used for both learning and evaluation.

  • 284. Botezatu, Mihaela
    et al.
    Hult, Håkan
    Kassaye Tessma, Mesfin
    Fors, Uno
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Virtual patient simulation: knowledge gain or knowledge loss?2010Inngår i: Medical Teacher, ISSN 0142-159X, Vol. 32, nr 7, s. 562-568Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Virtual patients (VPs), high-fidelity simulators and standardized patients are powerful educational interventions leading to effective learning and supporting knowledge retention.

    Aim: This study explored the variations in retention with VP versus regular learning activities.

    Method: We conducted a randomized controlled study on early and delayed assessment results of 49 students using VP for learning and examination of haematology and cardiology topics in an Internal Medicine course, by means of a 0–10 scoring rubric.

    Results: The mean difference for early assessment with VP (study – control mean score) was 1.43 (95% confidence interval (CI) 0.96, 1.91; p < 0.001) for haematology and 1.34 (95% CI 0.93, 1.76; p < 0.001) for cardiology. In regular exams, the mean score difference was 2.21 (95% CI 1.3, 3.1; p < 0.001) and 1.52 (95% CI 0.76, 2.28; p < 0.001), respectively. With delayed assessments, the difference in mean score for Web-SP was 1.48 (95% CI 1.09, 1.86; p < 0.001), haematology and 1.16 (95% CI 0.74, 1.58; p < 0.001), cardiology; for regular exams the figures were 1.96 (95% CI 0.93, 2.98; p < 0.001) and 1.74 (95% CI 0.89, 2.58; p < 0.001). The effect size ranged from 0.5 to 0.8.

    Conclusion: Our results indicate better retention with VP than with traditional learning methods.

  • 285. Botezatu, Mihaela
    et al.
    Hult, Håkan
    Tessma, Mesfin
    Dahlgren, Lars Owe
    Fors, Uno
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Virtual Patient Simulation: what do students make of it?: A focus group study2010Inngår i: BMC Medical Education, ISSN 1472-6920, E-ISSN 1472-6920, Vol. 10, nr 91Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    The learners' perspectives on Virtual Patient Simulation systems (VPS) are quintessential to their successful development and implementation. Focus group interviews were conducted in order to explore the opinions of medical students on the educational use of a VPS, the Web-based Simulation of Patients application (Web-SP).

    Methods

    Two focus group interviews-each with 8 undergraduate students who had used Web-SP cases for learning and/or assessment as part of their Internal Medicine curriculum in 2007-were performed at the Faculty of Medicine of Universidad el Bosque (Bogota), in January 2008. The interviews were conducted in Spanish, transcribed by the main researcher and translated into English. The resulting transcripts were independently coded by two authors, who also performed the content analysis. Each coder analyzed the data separately, arriving to categories and themes, whose final form was reached after a consensus discussion.

    Results

    Eighteen categories were identified and clustered into five main themes: learning, teaching, assessment, authenticity and implementation. In agreement with the literature, clinical reasoning development is envisaged by students to be the main scope of VPS use; transferable skills, retention enhancement and the importance of making mistakes are other categories circumscribed to this theme. VPS should enjoy a broad use across clinical specialties and support learning of topics not seen during clinical rotations; they are thought to have a regulatory effect at individual level, helping the students to plan their learning. The participants believe that assessment with VPS should be relevant for their future clinical practice; it is deemed to be qualitatively different from regular exams and to increase student motivation. The VPS design and content, the localization of the socio-cultural context, the realism of the cases, as well as the presence and quality of feedback are intrinsic features contributing to VPS authenticity.

    Conclusions

    Five main themes were found to be associated with successful VPS use in medical curriculum: Learning, Teaching, Assessment, Authenticity and Implementation. Medical students perceive Virtual Patients as important learning and assessment tools, fostering clinical reasoning, in preparation for the future clinical practice as young doctors. However, a number of issues regarding VPS design, authenticity and implementation need to be fulfilled, in order to reach the potential educational goals of such applications.

  • 286. Botezatu, Mihaela
    et al.
    Hult, Håkan
    Tessma, Mesfin
    Fors, Uno
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    As time goes by: stakeholder opinions on the implementation and use of a virtual patient simulation system2010Inngår i: Medical Teacher, ISSN 0142-159X (print), 1466-187X (electronic), Vol. 32, nr 11, s. e509-516Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Stakeholder opinions on the implementation of a particular virtual patient application might prove important for decision-making and implementation efforts in general. This study aimed to capitalize on experiences originated from two postimplementation settings of Web-based Simulation of Patients (Web-SP). Method: We conducted a cross-sectional survey of stakeholder opinions (39 students, teachers, course directors, and university leaders) on the implementation and use of Web-SP in Colombia and Sweden, using a mixed method approach. Results: The respondents did not show equal preference in rating the ranking of the order of importance included in the variables (Friedman’s Chi square: 26.5 to 115.1, df=6, p <0.001, Kendall’s coefficient of concordance ranging from 0.11 to 0.50). The answers provided as free comments supported the statistical findings on the importance of end-user customization, need for authenticity in software design, and use of virtual patient simulations in a curricular context, for clinical reasoning development. Conclusions: Virtual Patient design should allow extensive editing, support case authenticity and enhance clinical reasoning abilities, in an effort for ensuring accountability and sustainable development of the field.

  • 287.
    Boye, Johan
    et al.
    TeliaSonera (R & D).
    Gustafson, Joakim
    TeliaSonera (R & D).
    Wirén, Mats
    TeliaSonera (R & D).
    Robust spoken language understanding in a computer game2006Inngår i: Speech Communication, ISSN 0167-6393, E-ISSN 1872-7182, Vol. 48, nr 3-4, s. 335-353Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We present and evaluate a robust method for the interpretation of spoken input to a conversational computer game. The scenario of the game is that of a player interacting with embodied fairy-tale characters in a 3D world via spoken dialogue (supplemented by graphical pointing actions) to solve various problems. The player himself cannot directly perform actions in the world, but interacts with the fairy-tale characters to have them perform various tasks, and to get information about the world and the problems to solve. Hence the role of spoken dialogue as the primary means of control is obvious and natural to the player. Naturally, this means that robust spoken language understanding becomes a critical component. To this end, the paper describes a semantic representation formalism and an accompanying parsing algorithm which works off the output of the speech recogniser's statistical language model. The evaluation shows that the parser is robust in the sense of considerably improving on the noisy output of the speech recogniser.

  • 288.
    Boye, Johan
    et al.
    TeliaSonera.
    Wirén, Mats
    TeliaSonera.
    Multi-slot semantics for natural-language call routing systems2007Inngår i: Proceedings of Bridging the Gap: Academic and Industrial Research in Dialog Technology, 2007, s. 68-75Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Statistical classification techniques for natural-language call routing systems have matured to the point where it is possible to distinguish between several hundreds of semantic categories with an accuracy that is sufficient for commercial deployments. For category sets of this size, the problem of maintaining consistency among manually tagged utterances becomes limiting, as lack of consistency in the training data will degrade performance of the classifier. It is thus essential that the set of categories be structured in a way that alleviates this problem, and enables consistency to be preserved as the domain keeps changing. In this paper, we describe our experiences of using a two-level multi-slot semantics as a way of meeting this problem. Furthermore, we explore the ramifications of the approach with respect to classification, evaluation and dialogue design for call routing systems.

  • 289.
    Boye, Johan
    et al.
    TeliaSonera (R & D).
    Wirén, Mats
    TeliaSonera (R & D).
    Negotiative Spoken-Dialogue Interfaces to Databases2003Inngår i: Proceedings of Diabruck, Wallerfangen, Germany, 2003Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The aim of this paper is to develop a principled and empirically motivated approach to robust, negotiative spoken dialogue with databases. Robustness is achieved by limiting the set of representable utterance types. Still, the vast majority of utterances that occur in practice can be handled.

  • 290.
    Boye, Johan
    et al.
    TeliaSonera (R & D).
    Wirén, Mats
    TeliaSonera (R & D).
    Robust parsing and spoken negotiative dialogue with databases2008Inngår i: Natural Language Engineering, ISSN 1351-3249, E-ISSN 1469-8110, Vol. 14, nr 3, s. 289-312Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This paper presents a robust parsing algorithm and semantic formalism for the interpretation of utterances in spoken negotiative dialogue with databases. The algorithm works in two passes: a domain-specific pattern-matching phase and a domain-independent semantic analysis phase. Robustness is achieved by limiting the set of representable utterance types to an empirically motivated subclass which is more expressive than propositional slot–value lists, but much less expressive than first-order logic. Our evaluation shows that in actual practice the vast majority of utterances that occur can be handled, and that the parsing algorithm is highly efficient and accurate.

  • 291.
    Boye, Johan
    et al.
    TeliaSonera (R & D).
    Wirén, Mats
    TeliaSonera (R & D).
    Robust Parsing of Utterances in Negotiative Dialogue2003Inngår i: Proceedings 8th European Conference on Speech Communication and Technology (Eurospeech), Geneva, Switzerland, 2003Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This paper presents an algorithm for domain-dependent parsing of utterances in negotiative dialogue. To represent such utterances, the algorithm outputs semantic expressions that are more expressive than propositional slot-filler structures. It is very fast and robust, yet precise and capable of correctly combining information from different utterance fragments.

  • 292.
    Boye, Johan
    et al.
    TeliaSonera (R & D).
    Wirén, Mats
    TeliaSonera (R & D).
    Gustafson, Joakim
    TeliaSonera (R & D).
    Contextual reasoning in multimodal dialogue systems: two case studies2004Inngår i: Proceedings of The 8th Workshop on the Semantics and Pragmatics of Dialogue Catalogue'04, Barcelona, 2004, s. 19-21Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This paper describes an approach to contextual reasoning for interpretation ofspoken multimodal dialogue. The approach is based on combining recencybased search for antecedents with an object-oriented domain representation insuch a way that the search is highly constrained by the type information of theantecedents. By furthermore representingcandidate antecedents from the dialoguehistory and visual context in a uniformway, a single machinery (based on -reduction in lambda calculus) can be usedfor resolving many kinds of underspecified utterances. The approach has beenimplemented in two highly different domains.

  • 293.
    Brash, Danny
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Reuse in information systems development: a qualitative inquiry2002Doktoravhandling, monografi (Annet vitenskapelig)
  • 294. Bravos, George
    et al.
    Gonzalez Cardona, Tania
    Czubayko, Ulrich
    Donath, Janet
    España, Sergio
    Grabis, Janis
    Henkel, Martin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Jokste, Lauma
    Kampars, Janis
    Kuhr, Jan-Christian
    Loucopoulos, Pericles
    Juanes Pascual, Raul
    Stirna, Janis
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Valverde, Francisco
    Zdravkovic, Jelena
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Deliverable 1.2: Initial version of requirements specification for CDD: CaaS - Capability as a Service in digital enterprises, Collaborative Project Number 6113512013Rapport (Annet vitenskapelig)
    Abstract [en]

    The CaaS project will elaborate the Capability Driven Development (CDD) approach that will allow digital enterprises to exploit the notion of 'capability' as a means of both designing for services and with services. This deliverable defines an initial set of requirements for CDD. These requirements are provided by the industrial partners through exploration of their use cases. The goal of this deliverable is to identify potential benefits that the CaaS approach could bring to the use cases as well the features to be included the CDD methodology. The requirements are elicited from the use case partners during semi-structured interviews. They are documented in a form of goal models, actor models and concept models for each partner separately. Information documented in these models is used to define envisioned capabilities to be design and delivered during the project as well as to establish the scope of each use case. The use case scope definition focuses on use case goals, causes of capability delivery variability, capability delivery context, functions to be provided in the use case as well as potential capability delivery adjustments. The use case specific models are combined together to obtain a preliminary set of general requirements for CDD. These requirements show CDD goals, types of stakeholders, types of context and types of adjustments. The deliverable ends with concluding remarks about the partners’ expectations for CDD. The requirements for the use cases described in this deliverable will be further elaborated in the final requirements document deliverable D1.4 and will be iteratively refined during the use case elaboration performed in work packages WP2, WP3 and WP4.

  • 295. Bravos, George
    et al.
    Grabis, Janis
    Henkel, Martin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Jokste, Lauma
    Kampars, Janis
    Supporting Evolving Organizations: IS Development Methodology Goals2014Inngår i: Perspectives in Business Informatics Research: 13th International Conference, BIR 2014, Lund, Sweden, September 22-24, 2014. Proceedings / [ed] Björn Johansson, Bo Andersson, Nicklas Holmberg., Heidelberg: Springer , 2014, s. 158-171Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Organizations operate in increasingly dynamic and diverse environments. This leads to high variability within the organization, and the necessity to create context-aware information systems. As a part of these systems, context and business process metrics need to be monitored and acted upon. Capability Driven Development (CDD) addresses these challenges and integrates organizational development with IS (Information System) development. This paper integrates results from an industry survey and three industrial cases to define the key methodology goals for CDD.

  • 296.
    Brea, Oriana
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Mó, Otilia
    Yáñez, Manuel
    Merced Montero-Campillo, M.
    Alkorta, Ibon
    Elguero, José
    Are beryllium-containing biphenyl derivatives efficient anion sponges?2018Inngår i: Journal of Molecular Modeling, ISSN 1610-2940, E-ISSN 0948-5023, Vol. 24, nr 1, artikkel-id 16Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The structures and stabilities of 2,2'-diBeX-1,1'-biphenyl (X = H, F, Cl, CN) derivatives and their affinities for F-, Cl-, and CN- were theoretically investigated using a B3LYP/6-311 + G(3df, 2p)//B3LYP/6-31 + G(d,p) model. The results obtained show that the 2,2'-diBeX-1,1'-biphenyl derivatives (X = H, F, Cl, CN) exhibit very high F-, Cl-, and CN- affinities, albeit lower than those reported before for their 1,8-diBeX-naphthalene analogs, in spite of the fact that the biphenyl derivatives are more flexible than their naphthalene counterparts. Nevertheless, some of the biphenyl derivatives investigated are predicted to have anion affinities larger than those measured for SbF5, which is considered one of the strongest anion capturers. Therefore, although weaker than their naphthalene analogs, the 2,2'-diBeX-1,1'-biphenyl derivatives can still be considered powerful anion sponges. This study supports the idea that compounds containing -BeX groups in chelating positions behave as anion sponges due to the electron-deficient nature and consequently high intrinsic Lewis acidity of these groups.

  • 297.
    Britts, Stefan
    Stockholms universitet, Samhällsvetenskapliga fakulteten.
    Object database design1994Doktoravhandling, monografi (Annet vitenskapelig)
  • 298.
    Brodin, Jane
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för barn- och ungdomsvetenskap.
    Att stimulera barns lärande med stöd av IKT2010Inngår i: Specialpedagogisk tidskrift - att undervisa, ISSN 2000-429X, nr 1, s. 21-23Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    Barn med funktionsnedsättningar har ofta lyfts fram som vinnare när man talat om användning av IKT i skolan. Förväntningarna på vad IKT skulle medföra för elever i behov av särskilt stöd har varti stora både bland föräldrar och lärare. När den nya tekniken inroducerades antogs den kunna lösa många problem för barn med svårigheter av olika slag och därigenom bidra till att de bättre skulle kunna tillgodogöra sig undervisningen i skolan. Idag vet vi att det krävs mer än bara teknik.

  • 299.
    Brodin, Jane
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för barn- och ungdomsvetenskap.
    Computer play centres for children with disabilities2003Inngår i: Toys as communication (Nelson, Berg & Svensson, 2003).: Toy research in the late twentieth century, part 2, Stockholm: SITREC, KTH , 2003, s. 357-364Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    Many parents of children with severe disabilities complain that they experience difficulties in activating their child. They state that their child does not play or does not play independently and that the child is not interested in common toys. Computers offer new opportunities for many of these children.

  • 300.
    Brodin, Jane
    Stockholms universitet, Lärarhögskolan i Stockholm (LHS), Institutionen för individ, omvärld och lärande (IOL).
    ICT: a tool for play and communication2002Inngår i: Assistive Technology: shaping the future, Amsterdam: IOS Press , 2002, s. 185-189Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    ICT as a link for promoting inclusion of children with disabilities

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