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  • 51.
    Thornton, Brett F.
    et al.
    Stockholm University, Faculty of Science, Department of Geological Sciences.
    Burdette, Shawn C.
    Nobelium non-believers2014In: Nature Chemistry, ISSN 1755-4330, E-ISSN 1755-4349, Vol. 6, p. 652-652Article in journal (Other academic)
    Abstract [en]

    Alfred Nobel's eponymous element, nobelium, was 'first' discovered either in the 1950s or 1960s, in the USSR, Sweden or the USA. Brett F. Thornton and Shawn C. Burdette delve into the ensuing decades of internecine strife over the discovery of element 102.

  • 52.
    Thornton, Brett F.
    et al.
    Stockholm University, Faculty of Science, Department of Geological Sciences.
    Burdette, Shawn C.
    Recalling radon's recognition2013In: Nature Chemistry, ISSN 1755-4330, E-ISSN 1755-4349, Vol. 5, no 9, article id 804Article in journal (Other academic)
  • 53.
    Thornton, Brett F.
    et al.
    Stockholm University, Faculty of Science, Department of Geological Sciences.
    Burdette, Shawn C.
    The ends of elements2013In: Nature Chemistry, ISSN 1755-4330, E-ISSN 1755-4349, Vol. 5, no 5, p. 350-352Article in journal (Other academic)
    Abstract [en]

    When elements 117 and 118 are finally named, should these new members of the halogen and noble gas families receive names ending in -ium as IUPAC has suggested? Brett F. Thornton and Shawn C. Burdette look at the history of element suffixes and make the case for not following this recommendation.

  • 54.
    Thornton, Brett F.
    et al.
    Stockholm University, Faculty of Science, Department of Geological Sciences.
    Burdette, Shawn C.
    The straight dope on isotopes2013In: Nature Chemistry, ISSN 1755-4330, E-ISSN 1755-4349, Vol. 5, p. 979-981Article in journal (Other academic)
    Abstract [en]

    A century ago this month, Frederick Soddy described and named isotopes in the pages of Nature. Brett F. Thornton and Shawn C. Burdette discuss how chemists have viewed and used isotopes since then — either as chemically identical or chemically distinct species as the need required and technology allowed.

  • 55.
    Thornton, Brett F.
    et al.
    Stockholm University, Faculty of Science, Department of Geological Sciences.
    Burdette, Shawn C.
    Worcester Polytechnic Institute.
    Up for Discussion: Naming Superheavy Halogen and Noble Elements2013In: Chemistry International, ISSN 0193-6484, E-ISSN 1365-2192, Vol. 35, no 6, p. 26-27Article in journal (Other (popular science, discussion, etc.))
  • 56.
    Vijayaraghavan, Balaje
    Stockholm University, Faculty of Science, Department of Neurochemistry.
    Identification and characterization of protein-protein interactions in the nuclear envelope2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The nuclear envelope forms the interface between the nucleus and the cytoplasm. The nuclear envelope consists of the two concentric lipid membranes, the nuclear pores and the nuclear lamina. The inner nuclear membrane contains hundreds of unique transmembrane proteins showing high tissue diversity. Mutations of some proteins in the nuclear envelope give rise to a broad spectrum of diseases called envelopathies or laminopathies. In this thesis, I aimed to study the functional organization of the nuclear envelope by identifying and characterizing interactions between the nuclear envelope proteins. For this, we developed a novel method called the Membrane Protein Crosslink Immuno-Precipitation, which enable identification of protein-protein interactions in the nuclear envelope in live cells. We identified several novel interactions of the inner nuclear membrane protein, Samp1, and studied the interaction between the Samp1 and the nuclear GTPase, Ran in detail. Samp1 can bind to Ran and is thus the first known transmembrane Ran binding protein and Samp1 might provide a local binding site for Ran in the inner nuclear membrane. We found that Samp1 also binds to the inner nuclear membrane protein, Emerin and Ran can regulate the Samp1-Emerin interaction in the nuclear envelope. During mitosis, Samp1 distributes in the mitotic spindle. Therefore, we investigated a possible functional role of Samp1 in the mitotic machinery. Samp1 depletion resulted in aneuploid phenotypes, metaphase prolongation and decreased distribution of γ-tubulin and β-tubulin in the mitotic spindle. We found that Samp1 can bind to γ-tubulin, which is essential for the microtubule nucleation and hence for the spindle stability. The new interesting features of Samp1 provide insights on the unforeseen functions of the nuclear envelope proteins.

  • 57.
    Webling, Kristin
    Stockholm University, Faculty of Science, Department of Neurochemistry.
    Galanin receptor ligands: Design, synthesis, characterization and biological effects2016Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Galanin is a 29/30 amino acid long bioactive peptide discovered over 30 years ago when C-terminally amidated peptides were isolated from porcine intestines. The name galanin originates from a combination of the first and last amino acids - G from glycine and the rest from alanine. The first 15 amino acids are highly conserved among species which indicates that the N-terminus is important for receptor recognition and subsequent binding. Galanin exerts its effects by binding to three different G-protein coupled receptors, which all differ in regional distribution, the affinity for shortened galanin fragments, as well as the G-protein signaling cascade used. At the time of publication, galanin was found to cause muscle contraction as well as hyperglycemia.  Over the years, galanin has been reported to be involved in a wide variety of biological and pathological functions, for example epilepsy, food intake and depression.

    Determining the specific involvement of the three different galanin receptors in several biological and pathological processes is limited by the small amount of galanin receptor selective/specific ligands available as research tools. Furthermore, the fast degradation of peptides limits the administration routes in animal studies.

    This thesis aims at developing new galanin receptor-selective ligands to help delineate the involvement of the three different galanin receptors also known as the galaninergic system.

    Paper 1 demonstrates that the neuroprotective effects of galanin in a kainic acid induced excitotoxic animal model was mediated through galanin receptor 1. Furthermore, a new robust protocol for evaluating G-protein signaling using a label-free real time impedance technique was presented and compared to two different classical second-messenger assays.

    Paper 2 presents a series of systemically active galanin receptor 2 selective ligands subsequently evaluated in two different depression-like animal models.

    In conclusion, this thesis presents six new galanin ligands, which can be used to evaluate the galaninergic system as well as to investigate the possible use of peptides as pharmaceuticals.

  • 58.
    Yin, Ge
    Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. Stockholm University.
    Organohalogen contaminants in wildlife from the Yangtze River Delta: Development of methods and assessments of legacy and emerging persistent organic pollutants2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Rapid economic development has occurred during the past few decades in China with the Yangtze River Delta (YRD) area as one of the most progressive areas. The urbanization, industrialization, agricultural and aquaculture activities result in extensive production and application of chemicals. Organohalogen contaminants (OHCs) have been widely used as i.e. pesticides, flame retardants and plasticizers. They are persistent, bioaccumulative and pose a potential threat to ecosystem and human health. However, limited research has been conducted in the YRD with respect to chemicals environmental exposure.

    The main objective of this thesis is to investigate the contamination level, distribution pattern and sources of OHCs in the YRD. Wildlife from different habitats are used to indicate the environmental pollution situation, and evaluate selected matrices for use in long term biomonitoring to determine the environmental stress the contamination may cause. In addition, a method is developed for dicofol analysis. Moreover, a specific effort is made to introduce statistic power analysis to assist in optimal sampling design.

    The thesis results show extensive contamination of OHCs in wildlife in the YRD. The occurrences of high concentrations of chlorinated paraffins (CPs) are reported in wildlife, in particular in terrestrial species, (i.e. short-tailed mamushi snake and peregrine falcon). Impurities and byproducts of pentachlorophenol products, i.e. polychlorinated diphenyl ethers (PCDEs) and hydroxylated polychlorinated diphenyl ethers (OH-PCDEs) are identified and reported for the first time in eggs from black-crowned night heron and whiskered tern. High concentrations of octachlorodibenzo-p-dioxin (OCDD) are determined in these samples. The toxic equivalents (TEQs) of polychlorinated dibenzo-p-dioxin (PCDDs) and polychlorinated dibenzofurans (PCDFs) are at mean levels of 300 and 520 pg TEQ g-1lw (WHO2005 TEQ) in eggs from the two bird species, respectively. This is two orders of magnitude higher than European Union (EU) regulation limit in chicken eggs. Also, a novel pattern of polychlorinated biphenyls (PCBs) with octa- to decaCBs, contributing to as much as 20% of total PCBs therein, are reported in birds. The legacy POPs shows a common characteristic with relatively high level of organochlorine pesticides (i.e. DDT, hexacyclohexanes (HCHs) and Mirex), indicating historic applications. In contrast, rather low concentrations are shown of industrial chemicals such as PCBs and polybrominated diphenyl ethers (PBDEs).

    A refined and improved analytical method is developed to separate dicofol from its major decomposition compound, 4,4’-dichlorobenzophenone. Hence dicofol is possible to assess as such. Statistic power analysis demonstrates that sampling of sedentary species should be consistently spread over a larger area to monitor temporal trends of contaminants in a robust manner.

    The results presented in this thesis show high CPs and OCDD concentrations in wildlife. The levels and patterns of OHCs in YRD differ from other well studied areas of the world. This is likely due to the extensive production and use of chemicals in the YRD. The results strongly signal the need of research biomonitoring programs that meet the current situation of the YRD. Such programs will contribute to the management of chemicals and environment in YRD, with the potential to grow into the human health sector, and to expand to China as a whole.

  • 59.
    Yin, Ge
    et al.
    Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
    Danielsson, Sara
    Dahlberg, Anna-Karin
    Zhou, Yihui
    Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
    Qiu, Yanling
    Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
    Nyberg, Elisabeth
    Bignert, Anders
    Sampling designs for contaminant temporal trend analyses using sedentary species exemplified by the snails (Bellamya aeruginosa) and (Viviparus viviparus)Manuscript (preprint) (Other academic)
12 51 - 59 of 59
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