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2025 (English)In: Journal of Neurodevelopmental Disorders, ISSN 1866-1955, Vol. 17, article id 48Article in journal (Refereed) Published
Abstract [en]
Background People with Williams syndrome (WS) face challenges in various areas of cognitive processing, including attention. Previous studies suggest that these challenges are particularly pronounced when disengagement of attention from a previously attended stimulus is required, as compared to shifting attention without the need to disengage. Difficulties with attention could in turn be implicated in several of the behavioral characteristics of WS. Here, disengagement and shifting of visual attention, together with pupil dilation, were independently assessed in one of the largest eye-tracking studies of WS to date.
Methods We investigated shifting, disengagement, and the effects of auditory alerting cues on pupil dilation in WS individuals (n = 45, age range = 9–58 years), non-WS individuals with intellectual disability (ID) (n = 36, age range = 6–59 years), and typically developed (TD) infants (n = 32, age range = 6–7 months), children and adults (n = 31, age range = 9–60 years), using a modified gap-overlap task. Data were analyzed using linear mixed-effect models (LMMs).
Results Individuals with WS were less likely to shift their attention to upcoming targets than TD individuals (all ages), but more likely than the ID group to do so. When they did shift attention, participants with WS and ID were slower to initiate a gaze shift than TD participants regardless of whether disengagement was needed. In the WS group, failure to shift attention was strongly predicted by higher arousal (pupil dilation), which was induced by auditory alerting cues.
Conclusions Contrasting with previous theories of attention in WS, we found no evidence for a specific challenge in disengaging attention. Instead, our results point to a more general challenge in shifting attention. Reduced attention shifting in WS may be partly explained by atypical arousal regulation. These results contribute to our understanding of the WS phenotype.
Keywords
Williams syndrome, Orienting attention, Pupil dilation, Eye tracking, Visual disengagement, Shifting attention, Phasic alerting effect, Intellectual disability
National Category
Psychology Psychology (Excluding Applied Psychology)
Identifiers
urn:nbn:se:su:diva-246796 (URN)10.1186/s11689-025-09639-z (DOI)001550918500001 ()40804613 (PubMedID)2-s2.0-105013259126 (Scopus ID)
Funder
Stockholm University
2025-09-102025-09-102025-10-02Bibliographically approved