The biosphere crisis requires changes to existing business practices. We ask how corporations can become sustainability leaders, when constrained by multiple barriers to collaboration for biosphere stewardship. We describe how scientists motivated, inspired and engaged with ten of the world’s largest seafood companies, in a collaborative process aimed to enable science-based and systemic transformations (2015–2021). CEOs faced multiple industry crises in 2015 that incentivized novel approaches. New scientific insights, an invitation to collaborate, and a bold vision of transformative change towards ocean stewardship, created new opportunities and direction. Co-creation of solutions resulted in new knowledge and trust, a joint agenda for action, new capacities, international recognition, formalization of an organization, increased policy influence, time-bound goals, and convergence of corporate change. Independently funded scientists helped remove barriers to cooperation, provided means for reflection, and guided corporate strategies and actions toward ocean stewardship. By 2021, multiple individuals exercised leadership and the initiative had transitioned from preliminary and uncomfortable conversations, to a dynamic, operational organization, with capacity to perform global leadership in the seafood industry. Mobilizing transformational agency through learning, collaboration, and innovation represents a cultural evolution with potential to redirect and accelerate corporate action, to the benefit of business, people and the planet. 

Interdependence of social-ecological systems (SES) across the globe is rapidly increasing through increased connectivity, for example, through flow of information and trade. This case study of highly remote Himalayan villages in West Sikkim, India, explores how cross-scale interactions can shape the development of a local SES. In-depth interviews across four different institutional scales-state, district, gram panchayat unit and ward, show a rapid shift from subsistence farming to commercial monocultures of large cardamom in the lowland villages of the region. This, alongside a failure to address diverse needs within the policy implementation context, has resulted in economic inequality between lowland and upland villages. The interaction between state policies for conservation, national agriculture and food subsidies, and the effects of globalization are reducing the diversity of foods for the communities, as they become dependent on external markets and government subsidies for income and food. The case study is an example of how imposing uniform institutions can threaten SES to become increasingly homogenized and vulnerable to shocks.