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Title [sv]
Skräddarsydda mesoporösa material för additiv tillverkning av individanpassade läkemedel
Title [en]
Tailoring mesoporous materials for additive manufacturing of personalized medication (MesMatMed)
Abstract [en]
The project will develop new types of biocompatible mesoporous materials (MMs) and investigate how they can be optimized and functionalized as carriers of poorly soluble drugs in oral dosage forms and develop new additive manufacturing (AM) procedures for fabrication of the MMs as drug carriers. The ultimate societal goal is to form the technological basis for fast production (via AM in the clinic) of personalized medication for children, with the focus on cancer and neurological diseases. Although clinically different, these diseases share the problem that disease-specific drugs are difficult to formulate and no optimal oral pediatric dosage forms exists. Increased knowledge of how to synthesise biocompatible MMs in processes non-reliant on surfactants, MMs as drug delivery vehicles, how to tailor their properties to control the compatibility with other excipients and to tune the release profiles of active materials loaded into their pore structures are expected. The AM fabricated formulations can be transferred to other patient groups as global healthcare continues to move towards personalized medicine. Being the first to develop MMs for Binder Jetting 3D printing, the project may also open up for new AM procedures within other areas that can benefit from materials with pore structures on a nanoscale that can adsorb or release substances; e.g., cleantech applications involving intricately-shaped tools for purifying water and air or for harvesting clean water from humid air.
Principal InvestigatorStrömme, Maria
Coordinating organisation
Uppsala University
Funder
Period
2020-01-01 － 2023-12-31
National Category
Inorganic ChemistryOther Materials Engineering
Identifiers
DiVA, id: project:6640Project, id: 2019-03729_VR

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