A data-driven screening methodology is developed for estimating nutrient input and retention-delivery in catchments with measured water discharges and nutrient concentrations along the river network. The methodology is applied to the Sava River Catchment (SRC), a major transboundary catchment in southeast Europe, with seven monitoring stations along the main river, defining seven nested catchments and seven incremental subcatchments that are analysed and compared in this study. For the relatively large nested catchments (>40,000 km(2)), characteristic regional values emerge for nutrient input per unit area of around 30 T/yr/km(2) for dissolved inorganic nitrogen (DIN) and 2 T/yr/km(2) for total phosphorus (TP). For the smaller nested catchments and incremental subcatchments, corresponding values fluctuate and indicate hotspot areas with total nutrient inputs of 158 T/yr/km(2) for DIN and 13 T/yr/km(2) for TP. The delivered fraction of total nutrient input mass (termed delivery factor) and associated nutrient loads per area are scale-dependent, exhibiting power-law decay with increasing catchment area, with exponents of around 0.2-0.3 for DIN and 0.3-0.5 for TP. For the largest of the nested catchments in the SRC, the delivery factor is around 0.08 for DIN and 0.03 for TP. Overall, the nutrient data for nested catchments within the SRC show consistency with previously reported data for multiple nested catchments within the Baltic Sea Drainage Basin, identifying close nutrient relationships to driving hydroclimatic conditions (runoff for nutrient loads) and socio-economic conditions (population density and farmland share for nutrient concentrations).