Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Exponential increase in mortality with age is a generic property of a simple model system of damage accumulation and death
Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för folkhälsovetenskap.ORCID-id: 0000-0003-3827-8721
Rekke forfattare: 12020 (engelsk)Inngår i: PLOS ONE, E-ISSN 1932-6203, Vol. 15, nr 6, artikkel-id e0233384Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The risk of dying increases exponentially with age, in humans as well as in many other species. This increase is often attributed to the accumulation of damage known to occur in many biological structures and systems. The aim of this paper is to describe a generic model of damage accumulation and death in which mortality increases exponentially with age. The damage-accumulation process is modeled by a stochastic process know as a queue, and risk of dying is a function of the accumulated damage, i.e., length of the queue. The model has four parameters and the main characteristics of the model are: (i) damage occurs at random times with a constant high rate; (ii) the damage is repaired at a limited rate, and consequently damage can accumulate; (iii) the efficiency of the repair mechanism decays linearly with age; (iv) the risk of dying is a function of the accumulated damage. Using standard results from the mathematical theory of queues it is shown that there is an exponential dependence between risk of dying and age in these models, and that this dependency holds irrespective of how the damage-accumulation process is modeled. Furthermore, the ways in which this exponential dependence is shaped by the model parameters are also independent of the details of the damage accumulation process. These generic features suggest that the model could be useful when interpreting changes in the relation between age and mortality in real data. To exemplify, historical mortality data from Sweden are interpreted in the light of the model. The decrease in mortality seen between cohorts born in 1905, compared to those born in 1885, can be accounted for by higher threshold to damage. This fits well with the many advances made in public health during the 20th century.

sted, utgiver, år, opplag, sider
2020. Vol. 15, nr 6, artikkel-id e0233384
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-183670DOI: 10.1371/journal.pone.0233384ISI: 000542035200056PubMedID: 32497107OAI: oai:DiVA.org:su-183670DiVA, id: diva2:1455237
Tilgjengelig fra: 2020-07-22 Laget: 2020-07-22 Sist oppdatert: 2025-02-20bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Person

Ledberg, Anders

Søk i DiVA

Av forfatter/redaktør
Ledberg, Anders
Av organisasjonen
I samme tidsskrift
PLOS ONE

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 113 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf