Reconnecting humanity to the biosphere must be a focus in cities. Transforming cities to be inclusive, equitable, resilient, and sustainable requires rethinking our relationship to nature, and investing in urban development, design, and governance that brings nature into the center. We provide seven key insights drawn from the chapters in this book: (1) put nature-based solutions (NBS) first in adaptation to climate change in cities; (2) make equity and justice central in the design, planning, management, and governance of NBS in cities; (3) ensure biodiversity is a priority in urban planning for NBS; (4) employ and design NBS to improve human health in cities; (5) realize NBS in cities with inclusive urban planning and innovative governance approaches that respond to local context dynamics; (6) assess the holistic value of urban nature to make a case for NBS in cities; and (7) bring art into NBS and position art as a NBS in cities.