In the clinical application of ceramic prostheses, micro-leakage, porcelain chipping, low-treatment efficiency and quality uncertainty have appeared as the major problems that dentists encountered. However, the full-contour zirconia monolithic prostheses have the potentials for solving the problems. It appears that the full-contour zirconia monolithic prostheses produced through the fully digital workflow can ensure that the restorations can be closely aligned with the abutment and be easy to adjust and to wear, thus to assure the stability and accuracy of occlusal, which are crucial to the ultimate integration of the full-contour zirconia monolithic prostheses by avoiding unfavourable grinding. The newly developed full digital approach can greatly simplify the previous workflow that involved many manual operations. It improves not only the treatment efficiency but also the reliability of the prostheses by avoiding manual operational mistakes.