Drawing on multi-sited ethnographic fieldwork carried out in Bolivia and Spain, this article explores the reconfiguration of family relations maintained by middle-aged migrant women in a context of transnational migration. Indeed, transnational migration triggers contradictory feelings for those leaving and for those who stay behind. The individuals interviewed repeatedly express mixed feelings of guilt, pride, sadness and satisfaction, often interwoven with meaningful silences, demands, and expectations. In this particular instance, the aim is to visibilize the emotional dimension inherent in family relations at a distance to demonstrate how migration is also affected by the weight of care responsibilities, the family life course, gender roles, or intergenerational relations.