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Target analysis of synthetic phenolic antioxidants in human serum, prioritized by using an exposure index applied to the Swedish Products Register
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Analytical Chemistry.
2021 (English)Independent thesis Advanced level (degree of Master (Two Years)), 40 credits / 60 HE creditsStudent thesis
Abstract [en]

Chemicals entering the market have been steadily increasing. The Swedish Chemicals Agency is in control of the Swedish Products Register, which is storing information on chemicals  manufactured in, transferred, or imported into Sweden. Applied to the register comes the exposure index predicting exposure of chemicals. For this study, the exposure index was used to make a first prioritization of chemicals with potential of exposure to consumers, the list of suspects were further prioritized by in silico predicted physiochemical properties. Six synthetic antioxidants 2,4-di-tert-butylphenol, 2,6-di-tert-butyl-4-methylphenol, 2,4,6-tris-tert-butyl-phenol, 2,2´-methylene-bis(4-methyl-6-tert-butylphenol), 4,4´-methylene-bis(2,6-di-tert-butylphenol), octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenol) propionate), were selected for target analysis. Great care to background contamination is applied since the analytes are used in everyday objects such as food package and personal care products. Human serum samples was collected from “Blodcentralen” in Stockholm, Sweden. Previous analytical methods exist for individual and combination for a few analytes but lacks in combination of all selected analytes. A previous method for the extraction without clean-up of some of the analytes in serum were tested but lacked in efficiency for all analytes, hence an clean-up step for removal of lipids were added. A gas chromatography mass spectrometry method was developed for simultaneous analysis of the six analytes. Four of the target analytes were detected and three were quantified (2,4-di-tert-butylphenol 2.20-3.33 ng/mL, 2,6-di-tert-butyl-4-methylphenol 3.22-3.93 ng/mL and 2,4,6-tris-tert-butyl-phenol 0.054-0.104 ng/mL). 2,2´-methylene-bis(4-methyl-6-tert-butylphenol) was detected in high concentration but due to linearity problems (R2<0.99) it was not quantified. To the best of my knowledge this is the first time that 2,4,6-tri-tert-butylphenol and 2,2´- methylene-bis(4-methyl-6-tert-butylphenol) have been detected in human serum.

Place, publisher, year, edition, pages
2021.
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:su:diva-199959OAI: oai:DiVA.org:su-199959DiVA, id: diva2:1621766
Supervisors
Available from: 2021-12-20 Created: 2021-12-20 Last updated: 2021-12-20Bibliographically approved

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