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Improving the Timeliness of Early Prediction Models for Sepsis through Utility Optimization
Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.ORCID iD: 0000-0001-9731-1048
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
2022 (English)In: 2022 IEEE 34th International Conference on Tools with Artificial Intelligence (ICTAI), 2022, p. 1062-1069Conference paper, Published paper (Refereed)
Abstract [en]

Early prediction of sepsis can facilitate early intervention and lead to improved clinical outcomes. However, for early prediction models to be clinically useful, and also to reduce alarm fatigue, detection of sepsis needs to be timely with respect to onset, being neither too late nor too early. In this paper, we propose a utility-based loss function for training early prediction models, where utility is defined by a function according to when the predictions are made and in relation to onset as well as to specified early, optimal and late time points. Two versions of the utility-based loss function are evaluated and compared to a cross-entropy loss baseline. Experimental results, using real clinical data from electronic health records, show that incorporating the utility-based loss function leads to superior multimodal early prediction models, detecting sepsis both more accurately and more timely. We argue that improving the timeliness of early prediction models is important for increasing their utility and acceptance in a clinical setting.

Place, publisher, year, edition, pages
2022. p. 1062-1069
Series
Proceedings - International Conference on Tools with Artificial Intelligence (ICTAI), ISSN 1082-3409, E-ISSN 2375-0197
Keywords [en]
Early prediction, sepsis, electronic health records, multimodal learning
National Category
Natural Language Processing
Research subject
Computer and Systems Sciences
Identifiers
URN: urn:nbn:se:su:diva-216829DOI: 10.1109/ICTAI56018.2022.00162OAI: oai:DiVA.org:su-216829DiVA, id: diva2:1753999
Conference
International Conference on Tools with Artificial Intelligence (ICTAI), 31 October- 02 November, 2022, Macao, China.
Available from: 2023-05-02 Created: 2023-05-02 Last updated: 2025-02-07Bibliographically approved

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Lamproudis, AnastasiosHenriksson, Aron

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