Interoception refers to the sensing, interpreting, and integration of signals coming from the body (i.e., interoceptive signals) by the nervous system (Allen, 2020, Khalsa et al., 2018). Alterations in the processing of interoceptive signals is believed to significantly play a role in the development of mental health conditions (Barrett, 2017, Khalsa et al., 2018), and the methodology for human interoception research is expanding (Garfinkel et al., 2022). Investigations in the field have mostly been restricted to the domain of cardiovascular signals, as well as to the respiratory and gastrointestinal axes (Benson et al., 2012, Garfinkel et al., 2016, Khalsa and Lapidus, 2016). The reason is most likely that humans' appraisal of the status of these signals are commonly explicit and frequently occurring, and due to the fact that the assessment of perceptual alterations in interoceptive awareness (i.e., interoceptive attention, accuracy, intensity, sensibility, and insight) of these signals is convenient. There is less consensus regarding whether other types of bodily signals, such as the status of other organs or various hormonal levels, are reachable in an explicit manner. The study by Dimitroff et al. (2023) suggests, for the first time, that we humans can perhaps explicitly estimate our actual immune response.