Microfluidics – as most of us call their research field today; micro total analysis systems as it was named at the beginning of the 1990s, was heavily influenced by contributions from Andreas Manz. The first inventions and publications in the field of analytical chemistry, such as electrophoresis-on-chip and chromatography-on-chip, showed the amazing potential of miniaturized systems. The pioneering work for separation methods was followed by further seminal studies on bioanalytical and biological applications of microfluidic chips, such as PCR-on-chip, adaptations to various analytical detection methods, chemical reactors; and numerous more fancy ideas, such as powder-on-chip, leaves as molds, or the miniaturized London city map, with shortest travel distances visualized by a gas plasma. The world of microfluidics has very creative aspects and Andreas was one of the catalysts for the next generation of researchers.