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Unveiling Driver Modules in Lung Cancer: A Clustering-Based Gene-Gene Interaction Network Analysis
Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.ORCID iD: 0000-0002-2741-0355
Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.ORCID iD: 0000-0002-4632-4815
Number of Authors: 42025 (English)In: Machine Learning and Principles and Practice of Knowledge Discovery in Databases: International Workshops of ECML PKDD 2023, Turin, Italy, September 18–22, 2023, Revised Selected Papers, Part IV / [ed] Rosa Meo, Fabrizio Silvestri, Springer, 2025, p. 41-58Conference paper, Published paper (Refereed)
Abstract [en]

Lung cancer, which is the leading cause of cancer-related death worldwide and is characterized by genetic changes and heterogeneity, presents a significant treatment challenge. Existing approaches utilizing Machine Learning (ML) techniques for identifying driver modules lack specificity, particularly for lung cancer. This study addresses this limitation by proposing a novel method that combines gene-gene interaction network construction with ML-based clustering to identify lung cancer-specific driver modules. The methodology involves mapping biological processes to genes and constructing a weighted gene-gene interaction network to identify correlations within gene clusters. A clustering algorithm is then applied to identify potential cancer-driver modules, focusing on biologically relevant modules that contribute to lung cancer development. The results highlight the effectiveness and robustness of the clustering approach, identifying 110 unique clusters ranging in size from 4 to 10. These clusters surpass evaluation requirements and demonstrate significant relevance to critical cancer-related pathways. The identified driver modules hold promise for influencing future approaches to lung cancer diagnosis, prognosis, and treatment. This research expands our understanding of lung cancer and sets the stage for further investigations and potential clinical advancements.

Place, publisher, year, edition, pages
Springer, 2025. p. 41-58
Series
Communications in Computer and Information Science, ISSN 1865-0929, E-ISSN 1865-0937 ; 2136 CCIS
Keywords [en]
Driver Modules, Gene-Gene Interaction Network, Lung Cancer, Machine Learning
National Category
Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:su:diva-240214DOI: 10.1007/978-3-031-74640-6_4Scopus ID: 2-s2.0-85216025737ISBN: 9783031746390 (print)OAI: oai:DiVA.org:su-240214DiVA, id: diva2:1942811
Conference
International Workshops of ECML PKDD 2023, Turin, Italy, September 18–22, 2023
Available from: 2025-03-06 Created: 2025-03-06 Last updated: 2025-03-06Bibliographically approved

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Taheri, GolnazPapapetrou, Panagiotis

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