The battle against invasive alien species (IAS) rages on, and is being driven by recently articulated global biodiversity agendas. While the current United Nations Global Biodiversity Framework (GBF) seeks to ensure pristine, protected areas comprise 30 percent of the world’s total surface area by 2030, there remains much to be done for the remaining 70 percent, areas dominated by human habitat and industrial activities. Many non-native species have partly or wholly naturalized in these mixed ecosystems, becoming entangled in people’s livelihoods. We therefore argue that initiatives to not only aggressively eradicate such IAS but also to enroll the help of citizens in doing so will likely meet with resistance. Biodiversity dilemmas may arise where the cure may be worse than the disease; animal welfare standards may have to be sacrificed; and socioeconomic utility may have to be set aside. We therefore advocate the need for an alternative perspective on biodiversity justice and the proper place of IAS.