Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Olfactory dysfunction increases progression to dementia in cognitively impaired older adults: a 12-year population-based study
Stockholm University, Aging Research Center (ARC), (together with KI).ORCID iD: 0000-0002-3728-8410
Stockholm University, Faculty of Social Sciences, Department of Psychology.ORCID iD: 0000-0003-3418-0700
Show others and affiliations
Number of Authors: 62025 (English)In: GeroScience, ISSN 2509-2715Article in journal (Refereed) Epub ahead of print
Abstract [en]

Olfactory deficits are hypothesized to precede cognitive decline and be independently associated with future dementia. Conversely, the concurrency of cognitive and olfactory impairments is expected to represent an advanced stage, associated with shorter time to diagnosis. Limited research has examined the association of isolated and concurrent cognitive and olfactory impairments with incident dementia. We aimed to estimate the 12-year dementia hazard for cognitive impairment no dementia (CIND), olfactory dysfunction (OD), and their combination in a population-based cohort of older adults. We classified 2406 participants from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) based on baseline CIND and OD. Dementia hazard was estimated with Cox regressions for the whole period and two timeframes (baseline to 6-year follow-up and 6- to 12-year follow-up), and time until receiving a diagnosis via Laplace regressions. CIND+OD was associated with increased hazard ratio (HR) of dementia over 6 years (HR 11.38; 95% CI 6.70, 19.32; p < 0.001), higher for amnestic CIND+OD (HR 22.23; 95% CI 11.79, 41.90; p < 0.001). Isolated CIND was associated with dementia closest to baseline (HR 3.38; 95% CI 1.75, 6.49; p < 0.001), while isolated OD was associated with dementia closest (HR 2.56; 95% CI 1.48, 4.43; p < 0.001) and furthest (HR 2.12; 95% CI 1.41, 3.19; p < 0.001) to baseline. CIND+OD received their dementia diagnosis 3 years earlier. This study demonstrated that individuals with both cognitive and olfactory impairments have a higher short-term risk of progression to dementia and that OD may be a valuable early marker of dementia on its own.

Place, publisher, year, edition, pages
2025.
Keywords [en]
Dementia, Olfaction, Population-based study, Preclinical marker
National Category
Neurosciences Geriatrics
Identifiers
URN: urn:nbn:se:su:diva-248459DOI: 10.1007/s11357-025-01705-7ISI: 001498300500001PubMedID: 40437282Scopus ID: 2-s2.0-105006645699OAI: oai:DiVA.org:su-248459DiVA, id: diva2:2009806
Available from: 2025-10-29 Created: 2025-10-29 Last updated: 2025-10-29

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Ekström, IngridLarsson, Maria

Search in DiVA

By author/editor
Ekström, IngridLarsson, MariaGrande, Giulia
By organisation
Aging Research Center (ARC), (together with KI)Department of Psychology
NeurosciencesGeriatrics

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 5 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf