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A multi-season epidemic model with random genetic drift and transmissibility
Stockholm University, Faculty of Science, Department of Mathematics.ORCID iD: 0000-0002-9228-7357
Number of Authors: 22025 (English)In: Journal of Mathematical Biology, ISSN 0303-6812, E-ISSN 1432-1416, Vol. 91, no 6, article id 80Article in journal (Refereed) Published
Abstract [en]

We consider a model for the spread of an influenza-like disease in which, between seasons, the virus makes a random genetic drift (reducing immunity) and obtains a new random transmissibility (closely related to R0). Given the immunity status at the start of season k, i.e. the community distribution of years since last infection and their associated immunity levels, the outcome of the epidemic seasonĀ k, characterized by the effective reproduction number and the fractions infected in the different immunity groups , is determined by the random genetic drift and transmissibility. It is shown that the community immunity status of consecutive seasons, is an ergodic Markov chain, which converges to a stationary distribution. More analytical progress is made for the case where immunity only lasts for one season: we then characterize the stationary distribution of the community fraction having partial immunity (from being infected last season) as well as the stationary distribution of , and the conditional distribution of given . The effective reproduction number is closely related to the initial exponential growth rate of the outbreak, a quantity which can be estimated early in the epidemic season. As a consequence, this conditional distribution may be used for predicting the final size of the epidemic based on its initial growth and immunity status.

Place, publisher, year, edition, pages
2025. Vol. 91, no 6, article id 80
Keywords [en]
Attack ratio, Effective reproduction number, Seasonal flu, Stationary distribution, Viral drift
National Category
Epidemiology
Identifiers
URN: urn:nbn:se:su:diva-250093DOI: 10.1007/s00285-025-02308-8ISI: 001613227600001PubMedID: 41222727Scopus ID: 2-s2.0-105021461025OAI: oai:DiVA.org:su-250093DiVA, id: diva2:2018604
Available from: 2025-12-03 Created: 2025-12-03 Last updated: 2025-12-03Bibliographically approved

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Britton, Tom

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  • apa
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  • de-DE
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  • nn-NB
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