Part-time work is about twice as common in trade as in the general workforce in Sweden. More women than men work part time, and women and men tend to work in different trade sectors. This study first compares psychosocial work environment factors (job demands and job resources), work–non-work interference, and health-related factors between part-time and full-time employed women and men in trade in Sweden and, second, describes their sociodemographic characteristics. Data is from a subsample of trade employees in SLOSH 2022 (N = 730; 49% women; mean age 54 years; 92% permanently employed) with 20% in part-time employment. Part-time employees and women reported lower job resources (job control and skill discretion). Women reported higher emotional demands, work–life interference, and symptoms of depression. It is suggested that increased development opportunities and more varied job tasks could contribute to beneficial outcomes, especially for part-time employees and women, and more functional flexibility for organizations.