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Brain Tissue Context for Enhancing Brain Tumor Segmentation: A Contribution to BraTS 2025
Stockholm University, Faculty of Science, Department of Physics. Karolinska Institutet, Sweden.ORCID iD: 0000-0001-5125-4682
Stockholm University, Faculty of Science, Department of Physics. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-7101-240X
Number of Authors: 32026 (English)In: Segmentation, Classification, and Synthesis for Brain Tumors and Traumatic Brain Injuries: MICCAI 2025 Challenges: BraTS-Lighthouse 2025 and AIMS-TBI 2025, Held in Conjunction with MICCAI 2025, Daejeon, South Korea, September 23, 2025, Proceedings, Part I / [ed] Spyridon Bakas; Emily Dennis; Mehdi Astaraki; Ujjwal Baid; Gian Marco Conte; Martha Foltyn-Dumitru; Zhifan Jiang; Dominic Labella; Marie-Christin Metz; Udunna Anazodo; Maria Correia de Verdier; Florian Kofler; Hongwei Bran Li; Marius George Linguraru; Nazanin Maleki, Cham: Springer, 2026, p. 112-126Conference paper, Published paper (Refereed)
Abstract [en]

The development of deep learning methodologies has significantly impacted medical image segmentation, leading to highly accurate models for critical applications such as brain tumor delineation in MRI volumes. Precise tumor segmentation is indispensable for quantitative analysis, surgical planning, radiation treatment delivery, and disease monitoring. This paper presents a novel context-aware segmentation pipeline, conceptually rooted in anomaly detection, by integrating brain tissues as an auxiliary segmentation class. This inclusion enhances the discriminability between pathological and healthy tissues. To mitigate the class imbalance inherent in this added segmentation scheme, we incorporated a class-adaptive loss function within the nnU-Net and MedNeXt frameworks. The efficacy of this approach was rigorously evaluated on five tasks within the Brain Tumor Segmentation (BraTS) 2025 MICCAI Lighthouse challenge: adult glioma (GLI), pediatric glioma (PED), brain metastasis (MET), meningioma in pre-operative (MENpre), and meningioma in treatment planning (MENrt) segmentation. Our method demonstrated promising overall whole tumor segmentation performance on the validation set, yielding lesion-wise Dice scores of 0.873 (GLI), 0.945 (PED), 0.861 (MENpre), 0.845 (MENrt), and 0.679 (MET). The final phase of testing demonstrated that the proposed solutions performed among the top-ranked algorithms for the METMENpreMENrt, and GLI challenges.

Place, publisher, year, edition, pages
Cham: Springer, 2026. p. 112-126
Series
Lecture Notes in Computer Science, ISSN 0302-9743, E-ISSN 1611-3349 ; 16376
Keywords [en]
brain tumor, brats challenge, MRI, segmentation
National Category
Radiology and Medical Imaging
Identifiers
URN: urn:nbn:se:su:diva-256453DOI: 10.1007/978-3-032-16365-3_10Scopus ID: 2-s2.0-105037720272ISBN: 978-3-032-16364-6 (print)ISBN: 978-3-032-16365-3 (electronic)OAI: oai:DiVA.org:su-256453DiVA, id: diva2:2067738
Conference
28th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2025), Daejeon, Republic of Korea, September 23-27, 2025
Available from: 2026-06-08 Created: 2026-06-08 Last updated: 2026-08-10Bibliographically approved

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Astaraki, MehdiToma-Daşu, Iuliana

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