We show how land-use change can affect fisher-harvesting behavior. We test whether fisher harvesting behavior can be predicted by landscape change patterns at local (similar to 200 km) and regional (similar to 1200 km) levels. Our data suggest that fishers harvesting in areas near tree plantations reduced benthic-invertebrate harvests in favor of demersal and pelagic finfish that are usually located further offshore. Fishers' management areas, which were near tree plantations, had higher chlorophyll-a values, and contained shellfish with more endobionts. Technology (owning a boat) and experience (age, years fishing, and alternative livelihoods) explained little in fisher-harvesting behavior. The flagship Chilean fisheries management program and seafood companies sourcing from these areas will need to respond to these new challenges. Despite complexities in designing cross-scale, social-ecological studies, we can no longer ignore the interconnectedness of commodities in the biosphere.